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Grant Details

Grant Number: 5R01CA159463-12 Interpret this number
Primary Investigator: Sayette, Michael
Organization: University Of Pittsburgh At Pittsburgh
Project Title: Affective and Cognitive Processes in Smoking Craving
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): Smoking remains a leading preventable cause of mortality and morbidity. While it is relatively easy to develop nicotine dependence, it remains difficult to quit. Craving has been linked to nicotine dependence and the purpose of this competing renewal is to improve understanding of emotional and cognitive processes related to craving that underlie addiction. Because most lab-based craving studies involve subjects who do not expect to use the drug, the emotion experienced during such cravings tends to be negative. Outside the lab, however, cravings occur in conjunction with a variety of expectations regarding drug use, and in some cases are associated with positive anticipatory emotional states. A premise of the proposed study is that the loss of these positive "anticipatory" cravings after quitting constitutes a major challenge to remaining abstinent. The proposed laboratory research will apply theory and methods from experimental psychology to examine situational and individual difference factors that moderate the diverse effects of craving on affect and cognition, with particular emphasis on these positive craving states. The proposed study (n=300) will test the impact of treatment-seeking status (active vs. quitting smokers) and perceived smoking opportunity on a novel set of craving-related responses derived from basic research in emotion and cognitive science. To induce craving, abstinent smokers will be exposed to smoking cues, and instructions related to smoking opportunity will be manipulated. We also aim to evaluate the moderating effect of individual differences in personality, anhedonia, working memory, and dopamine-regulating gene variation on cravings. In addition, the proposed study will provide the first test to determine whether facial reactivity to smoking cues (coded using the Facial Action Coding System), can uniquely predict smoking relapse over an 8-week period following quitting. If successful, this test would offer early identification of those at high risk for relapse and suggest new directions for targeting affective processes in treatment. By tying craving to responses that are meaningfully linked to smoking, and that vary in different contexts and across individuals, the project aims to identify distinct craving patterns that may contribute to relapse risk. Irrespective of the outcome, the study will provide critical data regarding observable effects of an important but understudied form of anticipatory craving linked to positive affect, which will improve understanding of factors contributing to the etiology of nicotine addiction. In addition, identification of different emotional and cognitive experiences associated with positive cravings may lead to new directions for treatment that address the anhedonia and dysphoria smokers experience specifically as a result of losing these positive anticipatory experiences. PUBLIC HEALTH RELEVANCE: Craving is a cardinal feature of smoking addiction, which remains the leading cause of preventable mortality in the US. Despite its importance, research has relatively ignored the positive affect-related cravings often experienced by smokers while anticipating the smoking of their next cigarette. Understanding "positive" cravings, determining who is most sensitive to experiencing them, and examining the degree to which facial coding of these craving experiences can predict subsequent relapse, will advance knowledge regarding the emotional mechanisms underlying relapse and will suggest new directions for treatment that address the anhedonia and dysphoria smokers experience specifically as a result of losing these positive anticipatory experiences.

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Publications

Peak provoked craving: an alternative to smoking cue-reactivity.
Authors: Sayette MA, Tiffany ST
Source: Addiction, 2013 Jun;108(6), p. 1019-25.
EPub date: 2012 Oct 17.
PMID: 23075138
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Facial reactions to smoking cues relate to ambivalence about smoking.
Authors: Griffin KM, Sayette MA
Source: Psychol Addict Behav, 2008 Dec;22(4), p. 551-6.
PMID: 19071980
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Exploring the cold-to-hot empathy gap in smokers.
Authors: Sayette MA, Loewenstein G, Griffin KM, Black JJ
Source: Psychol Sci, 2008 Sep;19(9), p. 926-32.
PMID: 18947359
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Effect of smoking opportunity on responses to monetary gain and loss in the caudate nucleus.
Authors: Wilson SJ, Sayette MA, Delgado MR, Fiez JA
Source: J Abnorm Psychol, 2008 May;117(2), p. 428-34.
PMID: 18489219
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Carry-over effects of smoking cue exposure on working memory performance.
Authors: Wilson SJ, Sayette MA, Fiez JA, Brough E
Source: Nicotine Tob Res, 2007 May;9(5), p. 613-9.
PMID: 17454718
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Effects of smoking abstinence and alcohol consumption on smoking-related outcome expectancies in heavy smokers and tobacco chippers.
Authors: Kirchner TR, Sayette MA
Source: Nicotine Tob Res, 2007 Mar;9(3), p. 365-76.
PMID: 17365768
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The effects of alcohol on cigarette craving in heavy smokers and tobacco chippers.
Authors: Sayette MA, Martin CS, Wertz JM, Perrott MA, Peters AR
Source: Psychol Addict Behav, 2005 Sep;19(3), p. 263-70.
PMID: 16187804
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Instructed smoking expectancy modulates cue-elicited neural activity: a preliminary study.
Authors: Wilson SJ, Sayette MA, Delgado MR, Fiez JA
Source: Nicotine Tob Res, 2005 Aug;7(4), p. 637-45.
PMID: 16085533
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Validation of the nicotine dependence syndrome scale (NDSS): a criterion-group design contrasting chippers and regular smokers.
Authors: Shiffman S, Sayette MA
Source: Drug Alcohol Depend, 2005 Jul;79(1), p. 45-52.
EPub date: 2005 Feb 12.
PMID: 15943943
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Effects of smoking urge on temporal cognition.
Authors: Sayette MA, Loewenstein G, Kirchner TR, Travis T
Source: Psychol Addict Behav, 2005 Mar;19(1), p. 88-93.
PMID: 15783282
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Prefrontal responses to drug cues: a neurocognitive analysis.
Authors: Wilson SJ, Sayette MA, Fiez JA
Source: Nat Neurosci, 2004 Mar;7(3), p. 211-4.
EPub date: 2004 Feb 24.
PMID: 15001989
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Effects of smoking opportunity on cue-elicited urge: a facial coding analysis.
Authors: Sayette MA, Wertz JM, Martin CS, Cohn JF, Perrott MA, Hobel J
Source: Exp Clin Psychopharmacol, 2003 Aug;11(3), p. 218-27.
PMID: 12940501
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Effects of nicotine deprivation on craving response covariation in smokers.
Authors: Sayette MA, Martin CS, Hull JG, Wertz JM, Perrott MA
Source: J Abnorm Psychol, 2003 Feb;112(1), p. 110-8.
PMID: 12653419
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A multi-dimensional analysis of cue-elicited craving in heavy smokers and tobacco chippers.
Authors: Sayette MA, Martin CS, Wertz JM, Shiffman S, Perrott MA
Source: Addiction, 2001 Oct;96(10), p. 1419-32.
PMID: 11571061
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Effects of smoking opportunity on attentional bias in smokers.
Authors: Wertz JM, Sayette MA
Source: Psychol Addict Behav, 2001 Sep;15(3), p. 268-71.
PMID: 11563808
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A review of the effects of perceived drug use opportunity of self-reported urge.
Authors: Wertz JM, Sayette MA
Source: Exp Clin Psychopharmacol, 2001 Feb;9(1), p. 3-13.
PMID: 11519632
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The measurement of drug craving.
Authors: Sayette MA, Shiffman S, Tiffany ST, Niaura RS, Martin CS, Shadel WG
Source: Addiction, 2000 Aug;95 Suppl 2, p. S189-210.
PMID: 11002914
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