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Grant Details

Grant Number: 5R01CA126958-05 Interpret this number
Primary Investigator: Audrain-Mcgovern, Janet
Organization: University Of Pennsylvania
Project Title: The Protective Effects of Physical Activity on Adolescentsmoking Progression
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): Cigarette smoking is the leading preventable cause of morbidity and mortality in the U.S. About 23% of adolescents are regular smokers. To further reduce adolescent smoking, factors that protect against adolescent smoking need to be identified and subsequently incorporated into youth smoking prevention programs. Physical activity may be an important protective factor against youth smoking initiation and progression. Although longitudinal studies of smoking and physical activity indicate that higher levels of physical activity reduce the odds of adolescent smoking initiation and progression, the nature of this relationship, the mechanisms explaining this protective relationship, the amount of physical activity needed to confer a protective effect, and the adolescents at risk for smoking due to their levels of physical activity remain unclear. We propose to address this gap by creating a cohort of 1,000 adolescents (age 14 years) and following them over a four-year period (age 18 years). Socio-environmental, behavioral and psychological influences on smoking and physical inactivity will be collected. The aims of the proposed study are to (1) clarify the nature of the relationship between smoking and physical activity, (2) evaluate the mechanisms explaining the physical inactivity and smoking relationship, (3) empirically identify distinct longitudinal paths or smoking-physical inactivity trajectories to determine optimal intervention timing and the amount of physical activity needed to protect against smoking, and (4) characterize these trajectories by socio-environmental, behavioral and psychological variables to identify adolescents at risk for smoking within the context of their physical activity habits. Specific outcomes of interest include (a) odds and rates of progression to regular smoking and physical inactivity, and (b) longitudinal patterns or smoking-physical inactivity trajectories. This will be one of the first studies to concurrently and comprehensively evaluate smoking and physical activity from mid to late adolescence, to elucidate and quantify the protective relationship, and to explore how theory-based mechanisms relate to critical points in the development of a smoking habit often carried into adulthood. Results from this study can be used to inform the timing, type, amount of physical activity, target variables and important subpopulations for adolescent smoking prevention and intervention programs. Smoking and physical inactivity are two health risk behaviors often formed in adolescence and carried into adulthood. Although, the available longitudinal studies of smoking and physical activity indicate that higher levels of physical activity reduce the odds of adolescent smoking initiation and progression by 50%, the nature of this relationship, why physical activity is protective, and the amount of physical activity needed to confer a protective effect are unclear. This information is critical to for determining the content, timing, and targets for youth smoking prevention intervention that incorporates a physical activity component.

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Publications

Greater screen time is associated with adolescent obesity: a longitudinal study of the BMI distribution from Ages 14 to 18.
Authors: Mitchell JA, Rodriguez D, Schmitz KH, Audrain-McGovern J
Source: Obesity (Silver Spring), 2013 Mar;21(3), p. 572-5.
PMID: 23592665
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Initial insight into why physical activity may help prevent adolescent smoking uptake.
Authors: Audrain-McGovern J, Rodriguez D, Cuevas J, Sass J
Source: Drug Alcohol Depend, 2013 Oct 1;132(3), p. 471-8.
EPub date: 2013 Apr 9.
PMID: 23582953
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Sleep duration and adolescent obesity.
Authors: Mitchell JA, Rodriguez D, Schmitz KH, Audrain-McGovern J
Source: Pediatrics, 2013 May;131(5), p. e1428-34.
EPub date: 2013 Apr 8.
PMID: 23569090
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Longitudinal variation in adolescent physical activity patterns and the emergence of tobacco use.
Authors: Audrain-McGovern J, Rodriguez D, Rodgers K, Cuevas J, Sass J
Source: J Pediatr Psychol, 2012 Jul;37(6), p. 622-33.
EPub date: 2012 Mar 9.
PMID: 22408052
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Where is the pleasure in that? Low hedonic capacity predicts smoking onset and escalation.
Authors: Audrain-McGovern J, Rodriguez D, Leventhal AM, Cuevas J, Rodgers K, Sass J
Source: Nicotine Tob Res, 2012 Oct;14(10), p. 1187-96.
EPub date: 2012 Mar 1.
PMID: 22387990
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Reward expectations lead to smoking uptake among depressed adolescents.
Authors: Audrain-McGovern J, Rodriguez D, Rodgers K, Cuevas J, Sass J, Riley T
Source: Drug Alcohol Depend, 2012 Jan 1;120(1-3), p. 181-9.
EPub date: 2011 Aug 19.
PMID: 21855235
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