|Grant Number:||3U54CA116847-05S1 Interpret this number|
|Primary Investigator:||Mctiernan, Anne|
|Organization:||Fred Hutchinson Cancer Research Center|
|Project Title:||Mechanisms of Energy Balance and Cancer Prevention|
DESCRIPTION (provided by applicant): This is a competitive renewal application (in response to RFA-CA-10-006) "Transdisciplinary Research in Energetics and Cancer (U54)". The overarching theme of the Seattle TREC Center will be to determine mechanisms by which changes in energy balance influences cancer development and progression across the adult lifespan in small-scale and population-level human experimental studies. We propose to elucidate new pathways linking energy balance across the cancer continuum from the general population, to high risk individuals, to cancer survivors, using transdisciplinary methods that we developed in the first 5 years of TREC funding and capitalizing on our strengths in conducting human intervention trials. Project 1 will investigate, in a controlled feeding study, the role of caloric restriction plus a low glycemic load diet vs. low glycemic load diet alone in relation to an integrated set of endpoints: systemic insulin resistance and inflammation, adipose tissue inflammation and gut microbial community. Project 2 will test the effect of our group-based modification of the Diabetes Prevention Program weight loss intervention vs. control on prognosis-related biomarkers in breast cancer survivors including systemic metabolic and inflammatory markers, and breast aspirate cytology, proliferation, and gene expression. Project 3 will conduct a randomized trial evaluating a multi-level obesity prevention intervention in small worksites, where the intervention will include work, home, and neighborhood components. Additional novel work in the 3 projects will examine: weight loss effects on proteomics, caloric restriction effects on adipose expression of aromatase, the intersection of gut health with systemic insulin resistance and inflammation, and biology behavior interactions in weight loss and maintenance. Five Cores will support all Projects: the required Administration, Training/Education & Outreach, and Developmental, the recommended Biostatistics/Bioinformatics, and a Laboratory Core. A team of transdisciplinary researchers will collaborate across projects, including experts in epidemiology, oncology, nutrition, biochemistry, endocrinology, biostatistics, and behavioral science. The education/training and outreach program will include individual trainee mentoring and project experience, journal club, seminars, and national and international symposia and meetings on TREC-related topics. We propose to continue our outstanding record of cross-TREC center collaborations, where we have led several multi-center developmental studies. We propose to continue the strong leadership we have brought to the TREC community, and to continue our international leadership and contributions to the field of energy balance and cancer.
No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.
Authors: Duggan C, Xiao L, Terry MB, McTiernan A
Source: Obesity (Silver Spring), 2014 Sep;22(9), p. 2091-6.
EPub date: 2014 Jun 13.
Aspirin and serum estrogens in postmenopausal women: a randomized controlled clinical trial.
Authors: Duggan C, Wang CY, Xiao L, McTiernan A
Source: Cancer Prev Res (Phila), 2014 Sep;7(9), p. 906-12.
EPub date: 2014 Jun 12.
Effects of physical activity on melatonin levels in previously sedentary men and women.
Authors: Thrift AP, Xiao L, Patel SR, Tworoger SS, McTiernan A, Duggan C
Source: Cancer Epidemiol Biomarkers Prev, 2014 Aug;23(8), p. 1696-9.
EPub date: 2014 May 23.
Chronic sleep curtailment and adiposity.
Authors: Taveras EM, Gillman MW, Peņa MM, Redline S, Rifas-Shiman SL
Source: Pediatrics, 2014 Jun;133(6), p. 1013-22.
The effects of separate and combined dietary weight loss and exercise on fasting ghrelin concentrations in overweight and obese women: a randomized controlled trial.
Authors: Mason C, Xiao L, Imayama I, Duggan CR, Campbell KL, Kong A, Wang CY, Alfano CM, Blackburn GL, Foster-Schubert KE, McTiernan A
Source: Clin Endocrinol (Oxf), 2014 May 5;null, p. null.
EPub date: 2014 May 5.
Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors.
Authors: Duggan C, Risques R, Alfano C, Prunkard D, Imayama I, Holte S, Baumgartner K, Baumgartner R, Bernstein L, Ballard-Barbash R, Rabinovitch P, McTiernan A
Source: J Natl Cancer Inst, 2014 Apr;106(4), p. dju035.
EPub date: 2014 Mar 13.
Comparison and validation of 2 analytical methods for measurement of urinary sucrose and fructose excretion.
Authors: Song X, Navarro SL, Diep P, Thomas WK, Razmpoosh EC, Schwarz Y, Wang CY, Kratz M, Neuhouser ML, Lampe JW
Source: Nutr Res, 2013 Sep;33(9), p. 696-703.
EPub date: 2013 Jul 3.
Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: a randomized controlled trial.
Authors: Imayama I, Alfano CM, Mason C, Wang C, Duggan C, Campbell KL, Kong A, Foster-Schubert KE, Blackburn GL, Wang CY, McTiernan A
Source: Prev Med, 2013 Nov;57(5), p. 525-32.
EPub date: 2013 Jul 13.
Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women: a randomized controlled trial.
Authors: Mason C, Xiao L, Duggan C, Imayama I, Foster-Schubert KE, Kong A, Campbell KL, Wang CY, Alfano CM, Blackburn GL, Pollack M, McTiernan A
Source: Cancer Epidemiol Biomarkers Prev, 2013 Aug;22(8), p. 1457-63.
EPub date: 2013 Jun 11.
Predictors of adherence to a 26-week viniyoga intervention among post-treatment breast cancer survivors.
Authors: Cadmus-Bertram L, Littman AJ, Ulrich CM, Stovall R, Ceballos RM, McGregor BA, Wang CY, Ramaprasad J, McTiernan A
Source: J Altern Complement Med, 2013 Sep;19(9), p. 751-8.
EPub date: 2013 May 10.
Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women.
Authors: Mason C, Risques RA, Xiao L, Duggan CR, Imayama I, Campbell KL, Kong A, Foster-Schubert KE, Wang CY, Alfano CM, Blackburn GL, Rabinovitch PS, McTiernan A
Source: Obesity (Silver Spring), 2013 Dec;21(12), p. E549-54.
EPub date: 2013 Jul 29.
Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels.
Authors: Abbenhardt C, McTiernan A, Alfano CM, Wener MH, Campbell KL, Duggan C, Foster-Schubert KE, Kong A, Toriola AT, Potter JD, Mason C, Xiao L, Blackburn GL, Bain C, Ulrich CM
Source: J Intern Med, 2013 Aug;274(2), p. 163-75.
EPub date: 2013 Mar 29.
Associations of serum 25-hydroxyvitamin D with overall and breast cancer-specific mortality in a multiethnic cohort of breast cancer survivors.
Authors: Villaseņor A, Ballard-Barbash R, Ambs A, Bernstein L, Baumgartner K, Baumgartner R, Ulrich CM, Hollis BW, McTiernan A, Neuhouser ML
Source: Cancer Causes Control, 2013 Apr;24(4), p. 759-67.
EPub date: 2013 Jan 30.
Gene expression changes in adipose tissue with diet- and/or exercise-induced weight loss.
Authors: Campbell KL, Foster-Schubert KE, Makar KW, Kratz M, Hagman D, Schur EA, Habermann N, Horton M, Abbenhardt C, Kuan LY, Xiao L, Davison J, Morgan M, Wang CY, Duggan C, McTiernan A, Ulrich CM
Source: Cancer Prev Res (Phila), 2013 Mar;6(3), p. 217-31.
EPub date: 2013 Jan 22.
Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.
Authors: Mason C, Xiao L, Imayama I, Duggan CR, Foster-Schubert KE, Kong A, Campbell KL, Wang CY, Villasenor A, Neuhouser ML, Alfano CM, Blackburn GL, McTiernan A
Source: Med Sci Sports Exerc, 2013 Apr;45(4), p. 607-14.
Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study.
Authors: Villaseņor A, Ballard-Barbash R, Baumgartner K, Baumgartner R, Bernstein L, McTiernan A, Neuhouser ML
Source: J Cancer Surviv, 2012 Dec;6(4), p. 398-406.
EPub date: 2012 Oct 4.
Exercise adherence, cardiopulmonary fitness and anthropometric changes improve exercise self-efficacy and health-related quality of life.
Authors: Imayama I, Alfano CM, Mason CE, Wang C, Xiao L, Duggan C, Campbell KL, Foster-Schubert KE, Wang CY, McTiernan A
Source: J Phys Act Health, 2013 Jul;10(5), p. 676-89.
EPub date: 2012 Oct 4.
Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial.
Authors: Runchey SS, Valsta LM, Schwarz Y, Wang C, Song X, Lampe JW, Neuhouser ML
Source: Metabolism, 2013 Feb;62(2), p. 188-95.
EPub date: 2012 Sep 7.
History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women.
Authors: Mason C, Foster-Schubert KE, Imayama I, Xiao L, Kong A, Campbell KL, Duggan CR, Wang CY, Alfano CM, Ulrich CM, Blackburn GL, McTiernan A
Source: Metabolism, 2013 Jan;62(1), p. 127-36.
EPub date: 2012 Aug 14.
Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study.
Authors: Runchey SS, Pollak MN, Valsta LM, Coronado GD, Schwarz Y, Breymeyer KL, Wang C, Wang CY, Lampe JW, Neuhouser ML
Source: Eur J Clin Nutr, 2012 Oct;66(10), p. 1146-52.
EPub date: 2012 Aug 15.
DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a cross-sectional analysis.
Authors: Dee A, McKean-Cowdin R, Neuhouser ML, Ulrich C, Baumgartner RN, McTiernan A, Baumgartner K, Alfano CM, Ballard-Barbash R, Bernstein L
Source: BMC Cancer, 2012 Aug 8;12, p. 343.
EPub date: 2012 Aug 8.
Associations of insulin-like growth factor and insulin-like growth factor binding protein-3 with mortality in women with breast cancer.
Authors: Duggan C, Wang CY, Neuhouser ML, Xiao L, Smith AW, Reding KW, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R, McTiernan A
Source: Int J Cancer, 2013 Mar 1;132(5), p. 1191-200.
EPub date: 2012 Sep 1.
Self-monitoring and eating-related behaviors are associated with 12-month weight loss in postmenopausal overweight-to-obese women.
Authors: Kong A, Beresford SA, Alfano CM, Foster-Schubert KE, Neuhouser ML, Johnson DB, Duggan C, Wang CY, Xiao L, Jeffery RW, Bain CE, McTiernan A
Source: J Acad Nutr Diet, 2012 Sep;112(9), p. 1428-35.
EPub date: 2012 Jul 13.