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Grant Details

Grant Number: 5U24CA074783-13 Interpret this number
Primary Investigator: Gallinger, Steven
Organization: Cancer Care Ontario
Project Title: The Colon Cancer Family Registry: Ontario
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): The Ontario Familial Colorectal Cancer Registry (OFCCR) is a productive member of the multinational six site Colon Cooperative Family Registries (Colon CFR). During Phases I and II (1997-2007), the OFCCR registered population based subjects, with family history data, epidemiologic risk factor data, dietary data, and biospecimens (blood, serum, tumor blocks) for over 4,800 incident colorectal cancer (CRC) cases, their 4,000 relatives, as well as similar data for over 1,900 controls from the province of Ontario, Canada. The OFCCR has contributed approximately one-quarter of all CFR cases, and half the CFR-wide population controls. The OFCCR biospecimen repository (BSR) at Mount Sinai Hospital (MSH) in Toronto maintains and distributes to the scientific community genomic germline DMA from OFCCR cases and controls, all of which have been EBV transformed to protect this valuable resource. During Phase II, the OFCCR recruited additional high risk families from the clinic-based Familial Gastrointestinal Cancer Registry at MSH; 75 germline mismatch repair (MMR) gene mutation carriers and their relatives are now available for penetrance, epidemiologic, chemoprevention, psychosocial, and other research aimed at understanding familial and sporadic CRC. The OFCCR also contributed to the CFR, over 200 fresh frozen tumor samples, with annotated family history, epidemiologic and clinicopathologic data. Other unique contributions of the OFCCR to the Colon CFR include; germline MYH mutation testing of all Colon CFR cases and controls and the first genome wide association study in CRC that identified 8q24 SNPs that predict CRC susceptibility. In the current application (Phase III), the OFCCR proposes to continue as an active registry of the Colon CFR with the following Specific Aims: 1) expanding OFCCR families with MMR gene mutations, 2) recruiting additional high risk families from across Canada, 3) maintaining contact and follow-up of over 5,000 participants, 4) obtaining clinicopathologic and first treatment data on Phase I, II and III cases, 5) collaborating with the Colon CFR in molecular characterization of about 2,900 OFCCR cases (OFCCR will continue to test Colon CFR cases for MYH mutations), 6) adding to, and maintaining the OFCCR BSR and coordinating future efforts with the Colon CFR Central Repository, 7) maintaining the OFCCR bioinformatics core and coordinating efforts with RTI, the Informatics Center for the Colon CFR, 8) maintaining the OFCCR administrative core and contributing to the continued administrative efforts of the Colon CFR. The Colon CFR is the largest resource of its kind worldwide. Public health contributions of the OFCCR and the Colon CFR in general are far reaching including; providing a better understanding of susceptibility to CRC, identifying novel genetic markers of this disease, characterizing gene x gene and gene x environmental associations, and fostering clinicopathologic and psychosocial studies.

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Publications

Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bosetti C, Lucenteforte E, Bracci PM, Negri E, Neale RE, Risch HA, Olson SH, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham E, Holly EA, Gao YT, Yu H, Kurtz RC, Cotterchio M, Maisonneuve P, Zeegers MP, Duell EJ, Boffetta P, La Vecchia C
Source: Ann Oncol, 2013 Nov;24(11), p. 2903-10.
EPub date: 2013 Aug 22.
PMID: 23970016
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Allergies and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Olson SH, Hsu M, Satagopan JM, Maisonneuve P, Silverman DT, Lucenteforte E, Anderson KE, Borgida A, Bracci PM, Bueno-de-Mesquita HB, Cotterchio M, Dai Q, Duell EJ, Fontham EH, Gallinger S, Holly EA, Ji BT, Kurtz RC, La Vecchia C, Lowenfels AB, Luckett B, Ludwig E, Petersen GM, Polesel J, Seminara D, Strayer L, Talamini R, Pancreatic Cancer Case-Control Consortium
Source: Am J Epidemiol, 2013 Sep 1;178(5), p. 691-700.
EPub date: 2013 Jul 2.
PMID: 23820785
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Family history of hormonal cancers and colorectal cancer risk: a case-control study conducted in Ontario.
Authors: Jang JH, Cotterchio M, Gallinger S, Knight JA, Daftary D
Source: Int J Cancer, 2009 Aug 15;125(4), p. 918-25.
PMID: 19437533
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Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
Authors: Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey AB, Harper PA
Source: Cancer Epidemiol Biomarkers Prev, 2008 Nov;17(11), p. 3098-107.
PMID: 18990750
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Characterization of mutant MUTYH proteins associated with familial colorectal cancer.
Authors: Ali M, Kim H, Cleary S, Cupples C, Gallinger S, Bristow R
Source: Gastroenterology, 2008 Aug;135(2), p. 499-507.
EPub date: 2008 May 7.
PMID: 18534194
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Helicobacter pylori infection in Ontario: prevalence and risk factors.
Authors: Naja F, Kreiger N, Sullivan T
Source: Can J Gastroenterol, 2007 Aug;21(8), p. 501-6.
PMID: 17703249
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Allergies are associated with reduced pancreas cancer risk: A population-based case-control study in Ontario, Canada.
Authors: Eppel A, Cotterchio M, Gallinger S
Source: Int J Cancer, 2007 Nov 15;121(10), p. 2241-5.
PMID: 17582608
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Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.
Authors: Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey A, Harper P
Source: J Nutr, 2006 Dec;136(12), p. 3046-53.
PMID: 17116718
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Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies.
Authors: Green RC, Green JS, Buehler SK, Robb JD, Daftary D, Gallinger S, McLaughlin JR, Parfrey PS, Younghusband HB
Source: Fam Cancer, 2007;6(1), p. 53-62.
PMID: 17039269
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Association between colonic screening, subject characteristics, and stage of colorectal cancer.
Authors: Fazio L, Cotterchio M, Manno M, McLaughlin J, Gallinger S
Source: Am J Gastroenterol, 2005 Nov;100(11), p. 2531-9.
PMID: 16279911
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Colorectal screening is associated with reduced colorectal cancer risk: a case-control study within the population-based Ontario Familial Colorectal Cancer Registry.
Authors: Cotterchio M, Manno M, Klar N, McLaughlin J, Gallinger S
Source: Cancer Causes Control, 2005 Sep;16(7), p. 865-75.
PMID: 16132797
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Association between subject factors and colorectal cancer screening participation in Ontario, Canada.
Authors: Ramji F, Cotterchio M, Manno M, Rabeneck L, Gallinger S
Source: Cancer Detect Prev, 2005;29(3), p. 221-6.
PMID: 15896925
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The experience of loss and anticipation of distress in colorectal cancer patients undergoing genetic testing.
Authors: Esplen MJ, Urquhart C, Butler K, Gallinger S, Aronson M, Wong J
Source: J Psychosom Res, 2003 Nov;55(5), p. 427-35.
PMID: 14581097
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Agreement between proxy- and case-reported information obtained using the self- administered Ontario Familial Colon Cancer Registry epidemiologic questionnaire.
Authors: Nadalin V, Cotterchio M, McKeown-Eyssen G, Gallinger S
Source: Chronic Dis Can, 2003 Winter;24(1), p. 1-8.
PMID: 12757630
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A population-based study of the extent of surgical resection of potentially curable colon cancer.
Authors: Easson AM, Cotterchio M, Crosby JA, Sutherland H, Dale D, Aronson M, Holowaty E, Gallinger S
Source: Ann Surg Oncol, 2002 May;9(4), p. 380-7.
PMID: 11986190
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Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.
Authors: Lindor NM, Burgart LJ, Leontovich O, Goldberg RM, Cunningham JM, Sargent DJ, Walsh-Vockley C, Petersen GM, Walsh MD, Leggett BA, Young JP, Barker MA, Jass JR, Hopper J, Gallinger S, Bapat B, Redston M, Thibodeau SN
Source: J Clin Oncol, 2002 Feb 15;20(4), p. 1043-8.
PMID: 11844828
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Ontario familial colon cancer registry: methods and first-year response rates.
Authors: Cotterchio M, McKeown-Eyssen G, Sutherland H, Buchan G, Aronson M, Easson AM, Macey J, Holowaty E, Gallinger S
Source: Chronic Dis Can, 2000;21(2), p. 81-6.
PMID: 11007659
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