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Grant Details

Grant Number: 5R01CA121922-05 Interpret this number
Primary Investigator: Lipkus, Isaac
Organization: Duke University
Project Title: Young Smoker's Reactions to Genetic Risk for Lung Cancer
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): Genetic susceptibility testing has been heralded as the future of personalized risk assessments and health care delivery. Genetic susceptibility feedback may be very useful for increasing the salience of health risks to young smokers who while acknowledging the health risks of smoking, are unrealistically optimistic about experiencing the harms of smoking. However, personalizing risk could prompt young smokers' to have cognitive and emotional reactions that could attenuate the potential for susceptibility feedback to motivate smoking cessation. The standard of care for genetic testing, a multi-step process interspersed with periods of waiting and anticipation, offers a framework for testing whether delivery of susceptibility feedback is related to defensive and optimistic information processing of susceptibility feedback. We examine whether these processes occur at two times: 1) during the waiting time in which results are unknown, and 2) upon receipt of the result. At both times, we posit that cognitive and emotional processes may influence defensive and optimistic reactions and, in turn, may affect risk perceptions and inclinations to quit smoking, To this end, proposed is a four-year prospective randomized trial. The overarching aim is to understand college smokers' cognitive and emotional responses to genetic susceptibility feedback (GSTM1) and their influence on downstream perceptions of lung cancer risks and worry and initial steps towards cessation. Proactively recruited students who consent to participate will be randomized in a 2:1 ratio to undergo genetic testing or to a wait list control group. Measures of cognitive and emotional reactions will be collected from students who agree to be tested at four time points: baseline, at the time of testing, immediately prior to and after receipt of the test result. Similar measures will be collected at each time point for those declining testing and the wait-list control group. The primary dependent variables collected after receipt of feedback are: perceptions of personal lung cancer risks and lung cancer worry. In addition, we will examine how several cognitive and emotional anticipatory factors (e.g., test expectation) assessed immediately prior to receipt of result, moderate initial reactions to test feedback (Aim 1). We further examine how the cognitive and emotional reactions (e.g. counter-arguing) to the test result mediate perceptions of lung cancer risks and worry (Aim 2).

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Publications

Contemplating Genetic Feedback Regarding Lung Cancer Susceptibility.
Authors: Shepperd JA, Novell CA, O'Neill SC, Docherty SL, Sanderson SC, McBride CM, Lipkus IM
Source: Ann Behav Med, 2013 Nov 13;null, p. null.
EPub date: 2013 Nov 13.
PMID: 24222509
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Testing different communication formats on responses to imagined risk of having versus missing the GSTM1 gene.
Authors: Shepperd JA, Lipkus IM, Sanderson SC, McBride CM, O'Neill SC, Docherty S
Source: J Health Commun, 2013;18(1), p. 124-37.
EPub date: 2012 Aug 13.
PMID: 22888806
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Motivations for genetic testing for lung cancer risk among young smokers.
Authors: O'Neill SC, Lipkus IM, Sanderson SC, Shepperd J, Docherty S, McBride CM
Source: Tob Control, 2013 Nov;22(6), p. 406-11.
EPub date: 2012 Jun 28.
PMID: 22744911
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Young smokers' views of genetic susceptibility testing for lung cancer risk: minding unintended consequences.
Authors: Docherty SL, McBride CM, Sanderson SC, O'Neill SC, Shepperd JA, Lipkus IM
Source: J Community Genet, 2011 Sep;2(3), p. 165-72.
PMID: 21860660
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