|Grant Number:||3P50CA105641-05S2 Interpret this number|
|Primary Investigator:||Rebbeck, Timothy|
|Organization:||University Of Pennsylvania|
|Project Title:||Determinants of Disparity in Prostate Cancer Outcomes|
This Center for Population Health and Health Disparities (CPHHD) is being proposed to address significant gaps in our knowledge about factors that predict prostate cancer outcomes, and in particular the causes of disparity in prostate cancer outcomes between men of African and Caucasian descent. The mission of the proposed center is to 1) study the complex interaction of biological, clinical, behavioral, and environmental factors predictive of outcomes following a prostate cancer diagnosis, 2) evaluate how these factors explain disparities in prostate cancer outcomes by etnicity, and 3) disseminate this information to at-risk populations and the public health community. The CPHHD builds on our existing multidisciplinary research resources that include studies of the genetics, quality of life, patterns of care, physical environment, and social environment after the diagnosis of prostate cancer. This research requires transdisciplinary collaboration across molecular biology, genetic epidemiology, sociology, the behavioral sciences, and health policy. The proposed research has implications for clinical and public health practice, with potential to catalyze critical improvements in the prevention and treatment of prostate cancer. The CPHHD will address the following Specific Aims: Specific Aim 1: To undertake four highly interrelated research projects aimed at identifying factors that influence prostate cancer outcomes. These projects will evaluate the role of behavioral and environmental factors associated with physician and patient screening practices, screening behavior and genotypes on prostate cancer clinical outcomes, social and environmental factors on quality of life, and discrimination on treatment and medical outcomes after prostate cancer diagnoses. Specific Aim 2: To create three specialized cores to serve the needs of the CPHHD. These include: (1) an Administration Core to oversee and evaluate the CPHHD; (2) a Community Education and Dissemination Core to facilitate ongoing interactions with our community partners, and and to translate the information gained from this research to the public health community and general population; and (3) a Biomedical Informatics Core to provide integrated data management and to construct a comprehensive model of the multivariate biological, behavioral, social, and environmental factors on prostate cancer outcomes. Specific Aim 3: To solicit and support a series of focused high priority developmental (pilot) research projects. These projects will be chosen to extend the primary research projects to additional studies of cancer screening, biological interactions, statistical model building for the integration of complex data from various disciplines. The goal of these developmental projects is to expand the scope of the research proposed in the four Projects described here and to enhance the multidisciplinary research team with members representing additional disciplines and expertise.
Relationship of early-onset baldness to prostate cancer in African-American men.
Authors: Zeigler-Johnson C, Morales KH, Spangler E, Chang BL, Rebbeck TR
Source: Cancer Epidemiol Biomarkers Prev, 2013 Apr;22(4), p. 589-96.
EPub date: 2013 Mar 26.
Bridging the gap between biologic, individual, and macroenvironmental factors in cancer: a multilevel approach.
Authors: Lynch SM, Rebbeck TR
Source: Cancer Epidemiol Biomarkers Prev, 2013 Apr;22(4), p. 485-95.
EPub date: 2013 Mar 5.
What stresses men? Predictors of perceived stress in a population-based multi-ethnic cross sectional cohort.
Authors: Rebbeck TR, Weber AL, Spangler E, Zeigler-Johnson CM
Source: BMC Public Health, 2013 Feb 6;13, p. 113.
EPub date: 2013 Feb 6.
Analyzing genetic association studies with an extended propensity score approach.
Authors: Zhao H, Rebbeck TR, Mitra N
Source: Stat Appl Genet Mol Biol, 2012 Oct 19;11(5), p. null.
EPub date: 2012 Oct 19.
A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta.
Authors: Cabral WA, Barnes AM, Adeyemo A, Cushing K, Chitayat D, Porter FD, Panny SR, Gulamali-Majid F, Tishkoff SA, Rebbeck TR, Gueye SM, Bailey-Wilson JE, Brody LC, Rotimi CN, Marini JC
Source: Genet Med, 2012 May;14(5), p. 543-51.
EPub date: 2012 Jan 26.
Physician social networks and variation in prostate cancer treatment in three cities.
Authors: Pollack CE, Weissman G, Bekelman J, Liao K, Armstrong K
Source: Health Serv Res, 2012 Feb;47(1 Pt 2), p. 380-403.
EPub date: 2011 Oct 18.
Multi-institutional prostate cancer study of genetic susceptibility in populations of African descent.
Authors: Taioli E, Flores-Obando RE, Agalliu I, Blanchet P, Bunker CH, Ferrell RE, Jackson M, Kidd LC, Kolb S, Lavender NA, McFarlane-Anderson N, Morrison SS, Multigner L, Ostrande EA, Park JY, Patrick AL, Rebbeck TR, Romana M, Stanford JL, Ukoli F, Vancleave TT, Zeigler-Johnson CM, Mutetwa B, Ragin C
Source: Carcinogenesis, 2011 Sep;32(9), p. 1361-5.
EPub date: 2011 Jun 24.
Hospital racial composition and the treatment of localized prostate cancer.
Authors: Pollack CE, Bekelman JE, Liao KJ, Armstrong K
Source: Cancer, 2011 Dec 15;117(24), p. 5569-78.
EPub date: 2011 Jun 20.
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
Authors: Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, Cooney KA, Xu J, Kibel AS, Hu JJ, John EM, Gueye SM, Watya S, Signorello LB, Hayes RB, Wang Z, Yeboah E, Tettey Y, Cai Q, Kolb S, Ostrander EA, Zeigler-Johnson C, Yamamura Y, Neslund-Dudas C, Haslag-Minoff J, Wu W, Thomas V, Allen GO, Murphy A, Chang BL, Zheng SL, Leske MC, Wu SY, Ray AM, Hennis AJ, Thun MJ, Carpten J, Casey G, Carter EN, Duarte ER, Xia LY, Sheng X, Wan P, Pooler LC, Cheng I, Monroe KR, Schumacher F, Le Marchand L, Kolonel LN, Chanock SJ, Van Den Berg D, Stram DO, Henderson BE
Source: Nat Genet, 2011 Jun;43(6), p. 570-3.
EPub date: 2011 May 22.
Decision tree-based modeling of androgen pathway genes and prostate cancer risk.
Authors: Barnholtz-Sloan JS, Guan X, Zeigler-Johnson C, Meropol NJ, Rebbeck TR
Source: Cancer Epidemiol Biomarkers Prev, 2011 Jun;20(6), p. 1146-55.
EPub date: 2011 Apr 14.
Dissecting the within-Africa ancestry of populations of African descent in the Americas.
Authors: Stefflova K, Dulik MC, Barnholtz-Sloan JS, Pai AA, Walker AH, Rebbeck TR
Source: PLoS One, 2011 Jan 6;6(1), p. e14495.
EPub date: 2011 Jan 6.
Validation of genome-wide prostate cancer associations in men of African descent.
Authors: Chang BL, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, Benford ML, Kidd LR, Cooney K, Strom S, Ingles SA, Stern MC, Corral R, Joshi AD, Xu J, Giri VN, Rybicki B, Neslund-Dudas C, Kibel AS, Thompson IM, Leach RJ, Ostrander EA, Stanford JL, Witte J, Casey G, Eeles R, Hsing AW, Chanock S, Hu JJ, John EM, Park J, Stefflova K, Zeigler-Johnson C, Rebbeck TR
Source: Cancer Epidemiol Biomarkers Prev, 2011 Jan;20(1), p. 23-32.
EPub date: 2010 Nov 11.
Context-dependent effects of genome-wide association study genotypes and macroenvironment on time to biochemical (prostate specific antigen) failure after prostatectomy.
Authors: Rebbeck TR, Weber AL, Walker AH, Stefflova K, Tran TV, Spangler E, Chang BL, Zeigler-Johnson CM
Source: Cancer Epidemiol Biomarkers Prev, 2010 Sep;19(9), p. 2115-23.
Racial differences in quality of life following prostate cancer diagnosis.
Authors: Halbert CH, Coyne J, Weathers B, Mahler B, Delmoor E, Vaughn D, Malkowicz SB, Lee D, Troxel A
Source: Urology, 2010 Sep;76(3), p. 559-64.
EPub date: 2010 Mar 7.
Evaluation of group genetic ancestry of populations from Philadelphia and Dakar in the context of sex-biased admixture in the Americas.
Authors: Stefflova K, Dulik MC, Pai AA, Walker AH, Zeigler-Johnson CM, Gueye SM, Schurr TG, Rebbeck TR
Source: PLoS One, 2009 Nov 25;4(11), p. e7842.
EPub date: 2009 Nov 25.
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Authors: Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF
Source: Nat Genet, 2009 Oct;41(10), p. 1116-21.
EPub date: 2009 Sep 20.
Sociocultural determinants of men's reactions to prostate cancer diagnosis.
Authors: Halbert CH, Wrenn G, Weathers B, Delmoor E, Ten Have T, Coyne JC
Source: Psychooncology, 2010 May;19(5), p. 553-60.
The role of primary androgen deprivation therapy in localized prostate cancer.
Authors: Wong YN, Freedland SJ, Egleston B, Vapiwala N, Uzzo R, Armstrong K
Source: Eur Urol, 2009 Oct;56(4), p. 609-16.
EPub date: 2009 Apr 1.
Racial differences in the impact of comorbidities on survival among elderly men with prostate cancer.
Authors: Putt M, Long JA, Montagnet C, Silber JH, Chang VW, Kaijun Liao, Schwartz JS, Pollack CE, Wong YN, Armstrong K
Source: Med Care Res Rev, 2009 Aug;66(4), p. 409-35.
EPub date: 2009 Apr 8.