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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA090899-10 Interpret this number
Primary Investigator: Zheng, Wei
Organization: Vanderbilt University
Project Title: Molecular Epidemiologic Study of Breast Cancer
Fiscal Year: 2009
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Abstract

Most epidemiological studies of breast cancer have focused on investigations of genetic polymorphisms in the genes involved in estrogen and carcinogen metabolism. A number of promising associations have been identified, many of which have yet to be replicated. In this competitive renewal application, we propose to confirm some of the promising associations identified in the initial funding cycle and extend our work to the investigation of other novel genes in estrogen metabolism and several major genes in the pathways of angiogenesis, extracellular matrix remodeling, inflammatory response, and prostaglandin synthesis. These genes are involved in regulating the tumor microenvironment and are likely related to, not only the prognosis, but also the risk of cancers large enough to be detected clinically. The proposed study will use data and biological samples collected from the Shanghai Breast Cancer Study (RO1CA64277). Genetic polymorphisms in approximately 25 candidate genes will initially be evaluated using both genotype- and haplotype-approaches in approximately 1200 cases and 1200 controls recruited from 1996 to 1998. Promising associations identified in the initial phase will be re-evaluated in the second set of subjects (1300 cases and 1300 controls) recruited since 2002 in the parent study. This 2-phase study design will effectively balance both Type I and Type 2 errors and provide credible results towards our understanding of the etiology of breast cancer. Results from this study will be valuable in identifying high risk women for primary and secondary prevention of breast cancer.

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Publications

Genetic Polymorphisms In The Human Growth Hormone-1 Gene (gh1) And The Risk Of Breast Carcinoma
Authors: Ren Z. , Cai Q. , Shu X.O. , Cai H. , Cheng J.R. , Wen W.Q. , Gao Y.T. , Zheng W. .
Source: Cancer, 2004-07-15 00:00:00.0; 101(2), p. 251-7.
PMID: 15241820
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Oral Contraceptive Use And Breast Cancer Risk: Modification By Nad(p)h:quinone Oxoreductase (nqo1) Genetic Polymorphisms
Authors: Fowke J.H. , Shu X.O. , Dai Q. , Jin F. , Cai Q. , Gao Y.T. , Zheng W. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2004 Aug; 13(8), p. 1308-15.
PMID: 15298951
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The Long-term Impact Of Medical And Socio-demographic Factors On The Quality Of Life Of Breast Cancer Survivors Among Chinese Women
Authors: Cui Y. , Shu X.O. , Gao Y. , Cai H. , Wen W. , Ruan Z.X. , Jin F. , Zheng W. .
Source: Breast Cancer Research And Treatment, 2004 Sep; 87(2), p. 135-47.
PMID: 15377838
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Association Of Cyclin D1 Genotype With Breast Cancer Risk And Survival
Authors: Shu X.O. , Moore D.B. , Cai Q. , Cheng J. , Wen W. , Pierce L. , Cai H. , Gao Y.T. , Zheng W. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2005 Jan; 14(1), p. 91-7.
PMID: 15668481
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Expression Patterns Of The Atm Gene In Mammary Tissues And Their Associations With Breast Cancer Survival
Authors: Ye C. , Cai Q. , Dai Q. , Shu X.O. , Shin A. , Gao Y.T. , Zheng W. .
Source: Cancer, 2007-05-01 00:00:00.0; 109(9), p. 1729-35.
PMID: 17366603
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Haplotype Analysis Of Cyp11a1 Identifies Promoter Variants Associated With Breast Cancer Risk
Authors: Yaspan B.L. , Breyer J.P. , Cai Q. , Dai Q. , Elmore J.B. , Amundson I. , Bradley K.M. , Shu X.O. , Gao Y.T. , Dupont W.D. , et al. .
Source: Cancer Research, 2007-06-15 00:00:00.0; 67(12), p. 5673-82.
PMID: 17575134
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Erbb2 Genetic Polymorphism And Breast Cancer Risk In Chinese Women: A Population-based Case-control Study
Authors: Qu S. , Cai Q. , Gao Y.T. , Lu W. , Cai H. , Su Y. , Wang S.E. , Shu X.O. , Zheng W. .
Source: Breast Cancer Research And Treatment, 2008 Jul; 110(1), p. 169-76.
PMID: 17687647
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Genetic Polymorphisms Of Metastasis Suppressor Gene Nme1 And Breast Cancer Survival
Authors: Qu S. , Long J. , Cai Q. , Shu X.O. , Cai H. , Gao Y.T. , Zheng W. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2008-08-01 00:00:00.0; 14(15), p. 4787-93.
PMID: 18676749
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Association Of Mitochondrial Dna Displacement Loop (ca)n Dinucleotide Repeat Polymorphism With Breast Cancer Risk And Survival Among Chinese Women
Authors: Ye C. , Gao Y.T. , Wen W. , Breyer J.P. , Shu X.O. , Smith J.R. , Zheng W. , Cai Q. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Aug; 17(8), p. 2117-22.
PMID: 18708405
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A Two-stage Case-control Study Of Egfr Polymorphisms And Breast Cancer Risk
Authors: Hong Y.S. , Deming S.L. , Gao Y.T. , Long J.R. , Shu X.O. , Cai Q. , Lu W. , Zheng W. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Feb; 18(2), p. 680-3.
PMID: 19190167
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Heritable Variation Of Erbb2 And Breast Cancer Risk
Authors: Breyer J.P. , Sanders M.E. , Airey D.C. , Cai Q. , Yaspan B.L. , Schuyler P.A. , Dai Q. , Boulos F. , Olivares M.G. , Bradley K.M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Apr; 18(4), p. 1252-8.
PMID: 19336545
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Mutations In The Mitochondrial Dna D-loop Region And Breast Cancer Risk
Authors: Ye C. , Shu X.O. , Pierce L. , Wen W. , Courtney R. , Gao Y.T. , Zheng W. , Cai Q. .
Source: Breast Cancer Research And Treatment, 2010 Jan; 119(2), p. 431-6.
PMID: 19381801
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The Egfr Polymorphism Rs884419 Is Associated With Freedom From Recurrence In Patients With Resected Prostate Cancer
Authors: Perez C.A. , Chen H. , Shyr Y. , Courtney R. , Zheng W. , Cai Q. , Hwang M. , Jaboin J. , Schleicher S. , Moretti L. , et al. .
Source: The Journal Of Urology, 2010 May; 183(5), p. 2062-9.
PMID: 20303520
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Genome-wide Association Study Identifies A Common Variant Associated With Risk Of Endometrial Cancer
Authors: Spurdle A.B. , Thompson D.J. , Ahmed S. , Ferguson K. , Healey C.S. , O'Mara T. , Walker L.C. , Montgomery S.B. , Dermitzakis E.T. , Australian National Endometrial Cancer Study Group , et al. .
Source: Nature Genetics, 2011 May; 43(5), p. 451-4.
PMID: 21499250
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Fine-mapping Of The Hnf1b Multicancer Locus Identifies Candidate Variants That Mediate Endometrial Cancer Risk
Authors: Painter J.N. , O'Mara T.A. , Batra J. , Cheng T. , Lose F.A. , Dennis J. , Michailidou K. , Tyrer J.P. , Ahmed S. , Ferguson K. , et al. .
Source: Human Molecular Genetics, 2015-03-01 00:00:00.0; 24(5), p. 1478-92.
PMID: 25378557
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Candidate Locus Analysis Of The Tert-clptm1l Cancer Risk Region On Chromosome 5p15 Identifies Multiple Independent Variants Associated With Endometrial Cancer Risk
Authors: Carvajal-Carmona L.G. , O'Mara T.A. , Painter J.N. , Lose F.A. , Dennis J. , Michailidou K. , Tyrer J.P. , Ahmed S. , Ferguson K. , Healey C.S. , et al. .
Source: Human Genetics, 2015 Feb; 134(2), p. 231-45.
PMID: 25487306
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