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Grant Details

Grant Number: 3R01CA085942-05S2 Interpret this number
Primary Investigator: Field, R
Organization: University Of Iowa
Project Title: Iowa and Missouri Radon Lung Cancer Studies
Fiscal Year: 2007
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Abstract

Risk estimates, extrapolated from studies of underground miners, predict that residential radon progeny exposure accounts for approximately 19,000 lung cancer deaths each year in the United States. Previous case-control epidemiologic studies, which examined the relationship between residential radon exposure and lung cancer, lacked the ability to verify these risk estimates. Inaccurate dose assessment of radon exposure, a high percentage of proxy respondents, inadequate pathologic review, and low residential radon concentrations led to exposure misclassification and limited the interpretation of these studies. The Iowa Radon Lung Cancer Phase I study was designed to overcome many of these limitations. The Phase I study utilized advanced radon dose assessments, independent histologic review, and a study population that was characterized by geographic stability, high percentage of live cases, and potential for high radon exposure. The Phase I study demonstrated that exposure to residential radon gas increases the risk of developing lung cancer. To refine these estimates, we now propose Phase II studies that examine the association between residential radon product (progeny) exposure and the development of lung cancer. Because radon progeny deliver the actual radiation dose to the lung tissues, rather than radon gas itself, in order to reduce further the exposure misclassification, radon dose estimates need to take into account exposure to residential radon progeny. This requires measuring actual airborne radon progeny concentrations and integrating the exposure to radon progeny over time. The Phase II study will derive more accurate retrospective radon dose estimates by using a novel retrospective radon progeny integrating glass-based detector. Specific Aim I examines the hypothesis that exposure to residential radon progeny is associated with increased risk of developing lung cancer, after controlling for confounders. We will perform field calibration and laboratory validation of the retrospective radon "glass" detectors, and analyze the risk estimates by incorporating exposures to radon progeny, rather than exposures to radon gas. Specific Aim II will determine whether the shape of the dose response curve that best describes the relationship between residential radon progeny exposure and lung cancer risk is linear or nonlinear. Specific Aim III will examine whether exposure to radon progeny contributes to the development of adenocarcinoma, as well as other lung cancer histologic types. For Aims II and III we will use pooled analyses of exposure estimates that are derived from retrospective radon progeny "glass" detectors for subjects from the Iowa and Missouri Radon Lung Cancer Studies. The pooling of data between two large-scale epidemiologic studies from a similar geographic area, Iowa and Missouri, will allow us to increase sample size and statistical power.

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Publications

A comparison of winter short-term and annual average radon measurements in basements of a radon-prone region and evaluation of further radon testing indicators.
Authors: Barros NG, Steck DJ, Field RW
Source: Health Phys, 2014 May;106(5), p. 535-44.
PMID: 24670901
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Room model based Monte Carlo simulation study of the relationship between the airborne dose rate and the surface-deposited radon progeny.
Authors: Sun K, Field RW, Steck DJ
Source: Health Phys, 2010 Jan;98(1), p. 29-36.
PMID: 19959948
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Field investigation of surface-deposited radon progeny as a possible predictor of the airborne radon progeny dose rate.
Authors: Sun K, Steck DJ, Field RW
Source: Health Phys, 2009 Aug;97(2), p. 132-44.
PMID: 19590273
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Variation in yearly residential radon concentrations in the upper midwest.
Authors: Zhang Z, Smith B, Steck DJ, Guo Q, Field RW
Source: Health Phys, 2007 Oct;93(4), p. 288-97.
PMID: 17846525
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Iowa radon leukaemia study: a hierarchical population risk model for spatially correlated exposure measured with error.
Authors: Smith BJ, Zhang L, Field RW
Source: Stat Med, 2007 Nov 10;26(25), p. 4619-42.
PMID: 17373673
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Dosimetric challenges for residential radon epidemiology.
Authors: Steck DJ, Field RW
Source: J Toxicol Environ Health A, 2006 Apr;69(7), p. 655-64.
PMID: 16608831
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An overview of the North American residential radon and lung cancer case-control studies.
Authors: Field RW, Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Klotz JB, Létourneau EG, Lynch CF, Lyon JL, Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg C, Wilcox HB
Source: J Toxicol Environ Health A, 2006 Apr;69(7), p. 599-631.
PMID: 16608829
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A combined analysis of North American case-control studies of residential radon and lung cancer.
Authors: Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, Klotz JB, Létourneau EG, Lynch CF, Lyon JL, Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg C, Wilcox HB
Source: J Toxicol Environ Health A, 2006 Apr;69(7), p. 533-97.
PMID: 16608828
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Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies.
Authors: Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, Klotz JB, Létourneau EG, Lynch CF, Lyon JI, Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg C, Wilcox HB
Source: Epidemiology, 2005 Mar;16(2), p. 137-45.
PMID: 15703527
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Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review.
Authors: Field RW, Smith BJ, Platz CE, Robinson RA, Neuberger JS, Brus CP, Lynch CF
Source: J Natl Cancer Inst, 2004 Jul 21;96(14), p. 1105-7.
PMID: 15265973
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Residential radon exposure and lung cancer: variation in risk estimates using alternative exposure scenarios.
Authors: Field RW, Smith BJ, Steck DJ, Lynch CF
Source: J Expo Anal Environ Epidemiol, 2002 May;12(3), p. 197-203.
PMID: 12032816
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