|Grant Number:||5P50DA019706-10 Interpret this number|
|Primary Investigator:||Baker, Timothy|
|Organization:||University Of Wisconsin-Madison|
|Project Title:||Tobacco Dependence: Treatment and Outcomes|
Crucial knowledge gaps hinder our ability to treat nicotine dependence optimally. We know too little about the relative efficacies of pharmacotherapies in both clinical trials and real-world contexts. We know too little about how to deliver treatment: e.g., how to match patients with pharmacotherapies, how to incorporate treatment seamlessly into health care delivery systems and how to combine pharmacotherapies. In addition, we know too little about the global, long-term consequences of quit attempts: e.g., the downstream physiological, psychosocial, and health care utilization effects of continuing to smoke versus successfully quitting. Finally, we lack understanding of the mechanisms by which treatments work. These gaps will be addressed via four research projects and supportive cores. The first project (N=1520) will contrast efficacies of five different pharmacotherapies and a placebo, explore their mechanisms of action and yield algorithms for their optimal use. The second project will follow from the first project participants for at least 3 years and capture the diverse physical and psychosocial health outcomes of a quit attempt. The third project (N=1320) will study the active pharmacotherapies used in the first project, but in an effectiveness, primary care context. Data will address treatment utilization, success, and validate treatment algorithms. The fourth project will track from the third project subjects along with anonymous controls and reveal the impact of cessation on health care utilization and costs within a large network of primary care clinics. In addition, the UW-TTURC proposal includes an Administrative Core providing shared resources and infrastructure, a Career Development Core to increase the number of clinician-scientists entering the field of tobacco control research, and a Developmental Research Core to support innovative tobacco control research. The proposed work will advance the understanding and effectiveness of tobacco dependence treatment through integrated transdisciplinary research and result in more smokers quitting successfully.
Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.
Authors: Bergen AW, Michel M, Nishita D, Krasnow R, Javitz HS, Conneely KN, Lessov-Schlaggar CN, Hops H, Zhu AZ, Baurley JW, McClure JB, Hall SM, Baker TB, Conti DV, Benowitz NL, Lerman C, Tyndale RF, Swan GE, Transdisciplinary Research in Cancer of the Lung Research Team
Source: PLoS One, 2015;10(7), p. e0126113.
EPub date: 2015 Jul 1.
Organic cation transporter variation and response to smoking cessation therapies.
Authors: Bergen AW, Javitz HS, Krasnow R, Michel M, Nishita D, Conti DV, Edlund CK, Kwok PY, McClure JB, Kim RB, Hall SM, Tyndale RF, Baker TB, Benowitz NL, Swan GE
Source: Nicotine Tob Res, 2014 Dec;16(12), p. 1638-46.
EPub date: 2014 Aug 20.
Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction.
Authors: Chen LS, Baker TB, Piper ME, Smith SS, Gu C, Grucza RA, Smith GD, Munafo M, Bierut LJ
Source: Drug Alcohol Depend, 2014 Oct 1;143, p. 36-43.
EPub date: 2014 Jul 3.
Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6).
Authors: Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L
Source: Addiction, 2014 Jan;109(1), p. 128-37.
EPub date: 2013 Nov 11.
Transdisciplinary Tobacco Use Research Centers: research achievements and future implications.
Authors: Baker TB, Cummings KM, Hatsukami DK, Johnson CA, Lerman C, Niaura R, O'Malley SS
Source: Nicotine Tob Res, 2009 Oct;11(10), p. 1231-44.
EPub date: 2009 Jul 24.
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
Authors: Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert MF
Source: PLoS Genet, 2008 Jul 11;4(7), p. e1000125.
EPub date: 2008 Jul 11.
Assessing tobacco dependence: a guide to measure evaluation and selection.
Authors: Piper ME, McCarthy DE, Baker TB
Source: Nicotine Tob Res, 2006 Jun;8(3), p. 339-51.