Grant Details
| Grant Number: | 5R01CA114718-05 Interpret this number |
| Primary Investigator: | Mccain, Nancy |
| Organization: | Virginia Commonwealth University |
| Project Title: | Pni-Based Stress Management in Early Breast Cancer |
| Fiscal Year: | 2008 |
Abstract
DESCRIPTION (provided by applicant): A growing body of research with persons having chronic and potentially fatal illnesses such as cancer indicates that a variety of complementary "mind-body" interventions, including strategies for stress management, can not only mitigate psychological distress and improve coping skills, but also can enhance immune function through neuroendocrine-immune system modulation. Psychoneuroimmunology (PNI), the theoretical framework within which this proposal is grounded, is concerned with the mechanisms of multidimensional psychobehavioral-neuroendocrine-immune system interactions, including the influence of psychosocial, spiritual, and behavioral factors on health outcomes. To date, the majority of psycho behavioral studies in persons with cancer have not examined PNI-based biological indicators. While PNI-based research among persons with cancer is clearly indicated, the multiplicity and complexity of diseases and treatments render such research difficult, particularly in relation to the selection and measurement of appropriate biological markers. The customary immunological measures of lymphocyte proliferative function and natural killer cell cytotoxicity need to be augmented by investigations that may elucidate underlying mechanisms of immunosuppression, using measures such as patterns of cellular cytokine production. Additionally, the timing of such measures in relation to disease and treatment parameters must be carefully controlled and evaluated. This proposal directly addresses these issues by precisely controlling sample inclusion criteria, including medical treatment protocols, and by measuring multiple psycho behavioral, neuroendocrine, immunological, and health status variables over time. The proposed study is a randomized clinical trial involving 240 women receiving adjuvant chemotherapy for early breast cancer. The study is designed to test two psycho behavioral interventions, which we view holistically as mind-body-spirit interventions, and to evaluate multiple biological markers that may shed light on cancer- and treatment-specific mechanisms. The overarching hypothesis is that both tai chi training and spiritual growth group interventions will reduce perceived stress, enhance coping patterns, normalize levels of stress-related neuroendocrine mediators, attenuate immunosuppression, and enhance the adaptational outcomes of psychosocial functioning, quality of life, and physical health.
Publications
A critical review of a spirituality intervention.
Authors: Tuck I
Source: West J Nurs Res, 2012 Oct;34(6), p. 712-35.
EPub date: 2012 Feb 6.
PMID: 22309991
Related Citations
Grant Numbers:
| NCI NIH HHS - 5R01 CA114718 | NCCAM NIH HHS - 5R01 AT000331 | NCRR NIH HHS - 5M01 RR000065 |
MeSH Terms:
| Humans | Stress, Psychological | Spirituality |
| Clinical Trials as Topic | Quality of Life |
The story of the evolution of a unique tai chi form: origins, philosophy, and research.
Authors: Robins JL, Elswick RK, McCain NL
Source: J Holist Nurs, 2012 Sep;30(3), p. 134-46.
EPub date: 2012 Jan 6.
PMID: 22228833
Related Citations
Grant Numbers:
| NCRR NIH HHS - UL1 RR031990 | NCI NIH HHS - 5 R01 CA114718 | NCCAM NIH HHS - 5 R01 AT00331 |
| NINR NIH HHS - P30 NR011403 | NCRR NIH HHS - UL1RR031990 |
MeSH Terms:
Implementing a comprehensive approach to the study of health dynamics using the psychoneuroimmunology paradigm.
Authors: McCain NL, Gray DP, Walter JM, Robins J
Source: ANS Adv Nurs Sci, 2005 Oct-Dec;28(4), p. 320-32.
PMID: 16292018
Related Citations
Grant Numbers:
| NCCAM NIH HHS - R01 AT000331-05 | NCCAM NIH HHS - R01 AT000331 | NCI NIH HHS - R01 CA114718 |
| NINR NIH HHS - R01 NR04395 | NINR NIH HHS - R01 NR004395-03 | NCI NIH HHS - R01 CA114718-03 |
MeSH Terms:
| Neoplasms | HIV Infections | Adaptation, Psychological |
| Humans | Stress, Psychological | Models, Biological |
| Psychoneuroimmunology |
