Grant Details
| Grant Number: | 5R01CA116766-04 Interpret this number |
| Primary Investigator: | Baranowski, Tom |
| Organization: | Baylor College Of Medicine |
| Project Title: | Prop Sensitivity and Obesity Among Ethnic Children |
| Fiscal Year: | 2008 |
Abstract
Abstract: Obesity is multifactorial in origin. While energy imbalance is the proximal c# use of obesity, many factors influence energy imbalance. The genetically determined sensitivity to bitter taste (sensitivity to propylthiouracil (PROP)) has been inversely related to obesity among adults and to precursors of obesity (e.g. total energy) among young children. As a possible explanation for these relationships, PROP has also been inversely related to preferences for vegetables with a bitter taste, spicy foods (e g. capsaicin) and dietary fat intake. Thus, PROP sensitivity provides a genetically determined influence on behaviors which may lead to obesity among children. While there is a growing literature on PROP sensitivity in white adults, very little has been published among children or among ethnic minorities. It has not teen established whether this genetically determined trait is expressed at birth and remains constant through life, or if there are developmental influences on its expression. Early work on sensitivity to bitter tastes around the globe suggested large differences in this sensitivity across continents, and thereby ethnic groups. There; are no data, however, on whether the prevalence of PROP sensitivity differs by ethnic group in the US. Thus in one sample this research will assess the prevalence of PROP sensitivity among children in three age arid three ethnic groups, and assess the relationship of PROP sensitivity to adiposity status In a second sample, this research will also assess the relationship of PROP sensitivity to change in BMI over a 7 to 12 year period from 4 or 5 years of age to 12 to 16 years. In addition, both studies will test whether component; dietary intake mediate this relationship after controlling for energy expenditure and other possible confounding factors and whether psychosocial variables mediate the relationship of PROP status to FV intake. Knowing the prevalence of PROP sensitivity by age will specify possible differences in genetic expression by age. Differences in the prevalence by ethnic group could explain ethnic differences in obesity. Understanding how PROP sensitivity relates to obesity and food intake could provide an easily determined stratifying variable to which dietary interventions could be tailored.
Publications
Components of the diet associated with child adiposity: a cross-sectional study.
Authors: Ledoux TA, Watson K, Barnett A, Nguyen NT, Baranowski JC, Baranowski T
Source: J Am Coll Nutr, 2011 Dec;30(6), p. 536-46.
PMID: 22331689
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA 116766 |
MeSH Terms:
6-n-propylthiouracil taster status not related to reported cruciferous vegetable intake among ethnically diverse children.
Authors: Baranowski T, Baranowski JC, Watson KB, Jago R, Islam N, Beltran A, Martin SJ, Nguyen N, Tepper BJ
Source: Nutr Res, 2011 Aug;31(8), p. 594-600.
EPub date: 2011 Aug 5.
PMID: 21925344
Related Citations
Grant Numbers:
| NCI NIH HHS - CA116766 | NCI NIH HHS - R01 CA116766-04 |
MeSH Terms:
Overeating styles and adiposity among multiethnic youth.
Authors: Ledoux T, Watson K, Baranowski J, Tepper BJ, Baranowski T
Source: Appetite, 2011 Feb;56(1), p. 71-7.
EPub date: 2010 Nov 27.
PMID: 21115080
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA116766-01 | NCI NIH HHS - R01 CA116766 | NCI NIH HHS - R01 CA116766-03 |
| NCI NIH HHS - R01 CA116766-02 | NCI NIH HHS - R01 CA116766-04 |
MeSH Terms:
6-n-Propylthiouracil sensitivity and obesity status among ethnically diverse children.
Authors: Baranowski JC, Baranowski T, Beltran A, Watson KB, Jago R, Callie M, Missaghian M, Tepper BJ
Source: Public Health Nutr, 2010 Oct;13(10), p. 1587-92.
EPub date: 2009 Dec 22.
PMID: 20025833
Related Citations
Grant Numbers:
| NCI NIH HHS - CA116766 |
MeSH Terms:
| Obesity | Analysis of Variance | Propylthiouracil |
| Humans | Child | Body Mass Index |
| Taste | Income | Cross-Sectional Studies |
| Ethnic Groups | Social Class | Adolescent |
| Female | Male |
How many days was that? We're still not sure, but we're asking the question better!
Authors: Baranowski T, Mâsse LC, Ragan B, Welk G
Source: Med Sci Sports Exerc, 2008 Jul;40(7 Suppl), p. S544-9.
PMID: 18562972
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA116766-04 |
MeSH Terms:
| Reproducibility of Results | Humans | Motor Activity |
| Walking | Models, Theoretical |
Diverse food items are similarly categorized by 8- to 13-year-old children.
Authors: Beltran A, Knight Sepulveda K, Watson K, Baranowski T, Baranowski J, Islam N, Missaghian M
Source: J Nutr Educ Behav, 2008 May-Jun;40(3), p. 149-59.
PMID: 18457783
Related Citations
Grant Numbers:
| NIDDK NIH HHS - 5 U44 DK66724-01 | NCI NIH HHS - U01 CA130762-01 | NCI NIH HHS - R01 CA116766-03 |
MeSH Terms:
| Reproducibility of Results | Humans | Food |
| Databases, Factual | Mental Recall | Child |
| Adolescent | Cluster Analysis | Male |
| Female |
Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes.
Authors: Tepper BJ
Source: Annu Rev Nutr, 2008;28, p. 367-88.
PMID: 18407743
Related Citations
Grant Numbers:
| NCI NIH HHS - CA116766 |
MeSH Terms:
| Body Weight | Genetic Variation | Propylthiouracil |
| Food Preferences | Humans | Tongue |
| Taste | Taste Threshold |
