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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA082822-09 Interpret this number
Primary Investigator: Jacobsen, Paul
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Cognitive-Behavioral Aspects of Cancer-Related Fatigue
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): This competitive renewal application seeks continued support for a four-year study originally funded by the National Cancer Institute (1R01 CA82822). Funding for the original project began on 9/1/99 and will end on 6/30/03. A one year no-cost extension will expire on 6/30/04. The specific aims of the original study were to: 1) determine the severity and course of fatigue associated with treatment for early stage breast cancer; 2) characterize the cognitive, affective, and behavioral manifestations of fatigue associated with treatment for early stage breast cancer; and 3) test the utility of a cognitive-behavioral model designed to explain individual differences in fatigue among women receiving treatment for early stage breast cancer. Our work under the original proposal has yielded new insights into the severity, course, predictors, and correlates of fatigue during the active treatment period and during the first six months following completion of active treatment in women who received either chemotherapy followed radiotherapy or radiotherapy only. We believe that, by continuing to follow these two treated groups of patients as more time elapses following treatment completion, we have an opportunity to add significantly to knowledge about the nature of fatigue and its manifestations during an extended period of breast cancer survivorship. We note, however, the absence in our original design of comparison groups that would allow for determination of the extent to which the fatigue and related cognitive, behavioral, and affective problems exhibited by patients following completion of active treatment differ from "normal." In consideration of these issues, the specific aims of this competing continuation application are to: 1) determine the severity, course, and predictors of fatigue in the two treated groups over the first 3.5 years following completion of active treatment; 2) identify cognitive, behavioral, and affective problems associated with fatigue in the two treated groups over the fast 3.5 years following completion of active treatment; and 3) determine whether women who have completed active treatment for breast cancer experience greater fatigue and more related affective, cognitive and behavioral problems than women with no history of cancer matched for age, education, and geographic residence. To accomplish these aims we propose to: assess the two treated groups of patients again 3 years after completion of the final 6-month follow-up assessment currently being conducted; and recruit samples of women without cancer matched for age, education, and geographic residence with patients in each treated group and assess them on two occasions three years apart in order to generate comparison data. Provision of five years of continued funding will allow for uninterrupted follow-up of patients currently on study, the opportunity to collect complete 6-month and 3.5-year follow-up data on the two treated groups currently being followed, and the opportunity to collect complete initial and 3- year follow-up data matched comparison groups of women with no history of cancer.

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Publications

Relationship Of Catastrophizing To Fatigue Among Women Receiving Treatment For Breast Cancer
Authors: Jacobsen P.B. , Andrykowski M.A. , Thors C.L. .
Source: Journal Of Consulting And Clinical Psychology, 2004 Apr; 72(2), p. 355-61.
PMID: 15065968
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Course Of Fatigue In Women Receiving Chemotherapy And/or Radiotherapy For Early Stage Breast Cancer
Authors: Donovan K.A. , Jacobsen P.B. , Andrykowski M.A. , Winters E.M. , Balducci L. , Malik U. , Kenady D. , McGrath P. .
Source: Journal Of Pain And Symptom Management, 2004 Oct; 28(4), p. 373-80.
PMID: 15471655
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Use Of A Case Definition Approach To Identify Cancer-related Fatigue In Women Undergoing Adjuvant Therapy For Breast Cancer
Authors: Andrykowski M.A. , Schmidt J.E. , Salsman J.M. , Beacham A.O. , Jacobsen P.B. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-09-20 00:00:00.0; 23(27), p. 6613-22.
PMID: 16170168
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Relationship Of Problem-focused Coping Strategies To Changes In Quality Of Life Following Treatment For Early Stage Breast Cancer
Authors: Ransom S. , Jacobsen P.B. , Schmidt J.E. , Andrykowski M.A. .
Source: Journal Of Pain And Symptom Management, 2005 Sep; 30(3), p. 243-53.
PMID: 16183008
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Cognitive Functioning After Adjuvant Chemotherapy And/or Radiotherapy For Early-stage Breast Carcinoma
Authors: Donovan K.A. , Small B.J. , Andrykowski M.A. , Schmitt F.A. , Munster P. , Jacobsen P.B. .
Source: Cancer, 2005-12-01 00:00:00.0; 104(11), p. 2499-507.
PMID: 16247788
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Prospective, Longitudinal Study Of Leisure-time Exercise In Women With Early-stage Breast Cancer
Authors: Andrykowski M.A. , Beacham A.O. , Jacobsen P.B. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Mar; 16(3), p. 430-8.
PMID: 17372237
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Utility Of A Cognitive-behavioral Model To Predict Fatigue Following Breast Cancer Treatment
Authors: Donovan K.A. , Small B.J. , Andrykowski M.A. , Munster P. , Jacobsen P.B. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2007 Jul; 26(4), p. 464-72.
PMID: 17605566
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Fatigue After Treatment For Early Stage Breast Cancer: A Controlled Comparison
Authors: Jacobsen P.B. , Donovan K.A. , Small B.J. , Jim H.S. , Munster P.N. , Andrykowski M.A. .
Source: Cancer, 2007-10-15 00:00:00.0; 110(8), p. 1851-9.
PMID: 17847016
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Identifying Clinically Meaningful Fatigue With The Fatigue Symptom Inventory
Authors: Donovan K.A. , Jacobsen P.B. , Small B.J. , Munster P.N. , Andrykowski M.A. .
Source: Journal Of Pain And Symptom Management, 2008 Nov; 36(5), p. 480-7.
PMID: 18495413
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Magnitude And Correlates Of Response Shift In Fatigue Ratings In Women Undergoing Adjuvant Therapy For Breast Cancer
Authors: Andrykowski M.A. , Donovan K.A. , Jacobsen P.B. .
Source: Journal Of Pain And Symptom Management, 2009 Mar; 37(3), p. 341-51.
PMID: 18757176
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Cognitive Functioning In Breast Cancer Survivors: A Controlled Comparison
Authors: Jim H.S. , Donovan K.A. , Small B.J. , Andrykowski M.A. , Munster P.N. , Jacobsen P.B. .
Source: Cancer, 2009-04-15 00:00:00.0; 115(8), p. 1776-83.
PMID: 19224550
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Attitudes Toward Information About Genetic Risk For Cognitive Impairment After Cancer Chemotherapy: Breast Cancer Survivors Compared With Healthy Controls
Authors: Andrykowski M.A. , Burris J.L. , Walsh E. , Small B.J. , Jacobsen P.B. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2010-07-20 00:00:00.0; 28(21), p. 3442-7.
PMID: 20498392
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Breast Cancer Recurrence Risk Reduction Beliefs In Breast Cancer Survivors: Prevalence And Relation To Behavior
Authors: Burris J.L. , Jacobsen P.B. , Loftus L.S. , Andrykowski M.A. .
Source: Psycho-oncology, 2012 Apr; 21(4), p. 427-35.
PMID: 21312312
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History Of Major Depressive Disorder Prospectively Predicts Worse Quality Of Life In Women With Breast Cancer
Authors: Jim H.S. , Small B.J. , Minton S. , Andrykowski M. , Jacobsen P.B. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2012 Jun; 43(3), p. 402-8.
PMID: 22167580
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