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Grant Details

Grant Number: 5R01CA082822-09 Interpret this number
Primary Investigator: Jacobsen, Paul
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Cognitive-Behavioral Aspects of Cancer-Related Fatigue
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): This competitive renewal application seeks continued support for a four-year study originally funded by the National Cancer Institute (1R01 CA82822). Funding for the original project began on 9/1/99 and will end on 6/30/03. A one year no-cost extension will expire on 6/30/04. The specific aims of the original study were to: 1) determine the severity and course of fatigue associated with treatment for early stage breast cancer; 2) characterize the cognitive, affective, and behavioral manifestations of fatigue associated with treatment for early stage breast cancer; and 3) test the utility of a cognitive-behavioral model designed to explain individual differences in fatigue among women receiving treatment for early stage breast cancer. Our work under the original proposal has yielded new insights into the severity, course, predictors, and correlates of fatigue during the active treatment period and during the first six months following completion of active treatment in women who received either chemotherapy followed radiotherapy or radiotherapy only. We believe that, by continuing to follow these two treated groups of patients as more time elapses following treatment completion, we have an opportunity to add significantly to knowledge about the nature of fatigue and its manifestations during an extended period of breast cancer survivorship. We note, however, the absence in our original design of comparison groups that would allow for determination of the extent to which the fatigue and related cognitive, behavioral, and affective problems exhibited by patients following completion of active treatment differ from "normal." In consideration of these issues, the specific aims of this competing continuation application are to: 1) determine the severity, course, and predictors of fatigue in the two treated groups over the first 3.5 years following completion of active treatment; 2) identify cognitive, behavioral, and affective problems associated with fatigue in the two treated groups over the fast 3.5 years following completion of active treatment; and 3) determine whether women who have completed active treatment for breast cancer experience greater fatigue and more related affective, cognitive and behavioral problems than women with no history of cancer matched for age, education, and geographic residence. To accomplish these aims we propose to: assess the two treated groups of patients again 3 years after completion of the final 6-month follow-up assessment currently being conducted; and recruit samples of women without cancer matched for age, education, and geographic residence with patients in each treated group and assess them on two occasions three years apart in order to generate comparison data. Provision of five years of continued funding will allow for uninterrupted follow-up of patients currently on study, the opportunity to collect complete 6-month and 3.5-year follow-up data on the two treated groups currently being followed, and the opportunity to collect complete initial and 3- year follow-up data matched comparison groups of women with no history of cancer.

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Publications

History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer.
Authors: Jim HS, Small BJ, Minton S, Andrykowski M, Jacobsen PB
Source: Ann Behav Med, 2012 Jun;43(3), p. 402-8.
PMID: 22167580
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Breast cancer recurrence risk reduction beliefs in breast cancer survivors: prevalence and relation to behavior.
Authors: Burris JL, Jacobsen PB, Loftus LS, Andrykowski MA
Source: Psychooncology, 2012 Apr;21(4), p. 427-35.
EPub date: 2011 Feb 10.
PMID: 21312312
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Attitudes toward information about genetic risk for cognitive impairment after cancer chemotherapy: breast cancer survivors compared with healthy controls.
Authors: Andrykowski MA, Burris JL, Walsh E, Small BJ, Jacobsen PB
Source: J Clin Oncol, 2010 Jul 20;28(21), p. 3442-7.
EPub date: 2010 May 24.
PMID: 20498392
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Cognitive functioning in breast cancer survivors: a controlled comparison.
Authors: Jim HS, Donovan KA, Small BJ, Andrykowski MA, Munster PN, Jacobsen PB
Source: Cancer, 2009 Apr 15;115(8), p. 1776-83.
PMID: 19224550
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Magnitude and correlates of response shift in fatigue ratings in women undergoing adjuvant therapy for breast cancer.
Authors: Andrykowski MA, Donovan KA, Jacobsen PB
Source: J Pain Symptom Manage, 2009 Mar;37(3), p. 341-51.
EPub date: 2008 Aug 30.
PMID: 18757176
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Identifying clinically meaningful fatigue with the Fatigue Symptom Inventory.
Authors: Donovan KA, Jacobsen PB, Small BJ, Munster PN, Andrykowski MA
Source: J Pain Symptom Manage, 2008 Nov;36(5), p. 480-7.
EPub date: 2008 May 20.
PMID: 18495413
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Fatigue after treatment for early stage breast cancer: a controlled comparison.
Authors: Jacobsen PB, Donovan KA, Small BJ, Jim HS, Munster PN, Andrykowski MA
Source: Cancer, 2007 Oct 15;110(8), p. 1851-9.
PMID: 17847016
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Utility of a cognitive-behavioral model to predict fatigue following breast cancer treatment.
Authors: Donovan KA, Small BJ, Andrykowski MA, Munster P, Jacobsen PB
Source: Health Psychol, 2007 Jul;26(4), p. 464-72.
PMID: 17605566
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Prospective, longitudinal study of leisure-time exercise in women with early-stage breast cancer.
Authors: Andrykowski MA, Beacham AO, Jacobsen PB
Source: Cancer Epidemiol Biomarkers Prev, 2007 Mar;16(3), p. 430-8.
PMID: 17372237
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Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma.
Authors: Donovan KA, Small BJ, Andrykowski MA, Schmitt FA, Munster P, Jacobsen PB
Source: Cancer, 2005 Dec 1;104(11), p. 2499-507.
PMID: 16247788
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Relationship of problem-focused coping strategies to changes in quality of life following treatment for early stage breast cancer.
Authors: Ransom S, Jacobsen PB, Schmidt JE, Andrykowski MA
Source: J Pain Symptom Manage, 2005 Sep;30(3), p. 243-53.
PMID: 16183008
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Use of a case definition approach to identify cancer-related fatigue in women undergoing adjuvant therapy for breast cancer.
Authors: Andrykowski MA, Schmidt JE, Salsman JM, Beacham AO, Jacobsen PB
Source: J Clin Oncol, 2005 Sep 20;23(27), p. 6613-22.
PMID: 16170168
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Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer.
Authors: Donovan KA, Jacobsen PB, Andrykowski MA, Winters EM, Balducci L, Malik U, Kenady D, McGrath P
Source: J Pain Symptom Manage, 2004 Oct;28(4), p. 373-80.
PMID: 15471655
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Relationship of catastrophizing to fatigue among women receiving treatment for breast cancer.
Authors: Jacobsen PB, Andrykowski MA, Thors CL
Source: J Consult Clin Psychol, 2004 Apr;72(2), p. 355-61.
PMID: 15065968
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