|Grant Number:||3U01CA078296-05S4 Interpret this number|
|Primary Investigator:||Anton-Culver, Hoda|
|Organization:||University Of California-Irvine|
|Project Title:||NCI Cfrbccs Informatics Center at Uci|
DESCRIPTION: Advanced technology for mutation detection, the cloning of several cancer susceptibility genes, and high-throughput sequencing of genes make obsolete many of the previous and some of the current research strategies in the genetic epidemiology of cancer. In addition, the clinical implications of inherited mutations will need to be defined and communicated to health care providers and cancer genetics professionals. To provide an infrastructure for studies in human cancer genetics of unprecedented size and complexity, the National Cancer Institute has initiated the Cooperative Family Registry for Breast and Colon Cancer Studies (CFRBCCS). Integral to this effort will be a state-of-the-art Informatics Center (IC), that will develop, implement, and maintain a central informatics system and provide technical expertise for the development of information technologies, statistical methodology, and study design. Collectively, the University of California at Irvine (UCI), Dartmouth Medical School, and the University of Southern California have extensive experience in developing information management systems, participating in and coordinating multi-center research efforts, and developing advanced techniques in biostatistics. Further, leading international experts in biostatistics, genetic epidemiology, and molecular genetics will participate as members in the Biostatistics, Genetics, and Epidemiology Consortium, to provide technical expertise to CFRBCCS researchers. Our specific aims are: 1) Develop, implement, and maintain a single central informatics system at UCI, 2) Provide summary data, support, and coordination for the CFRBCCS registries, 3) Provide technical expertise regarding statistical issues, study design, methodology, and information technologies for the Registries, through an international consortium of leading experts in biostatistics, genetic epidemiology, and molecular genetics, 4) Carry out the responsibility for the CFRBCCS Study-wide communication, coordination, and administrative duties.
Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Authors: Kerber RA, Amos CI, Yeap BY, Finkelstein DM, Thomas DC
Source: BMC Med Genet, 2008 Jul 10;9, p. 64.
EPub date: 2008 Jul 10.
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations.
Authors: Andrulis IL, Anton-Culver H, Beck J, Bove B, Boyd J, Buys S, Godwin AK, Hopper JL, Li F, Neuhausen SL, Ozcelik H, Peel D, Santella RM, Southey MC, van Orsouw NJ, Venter DJ, Vijg J, Whittemore AS, Cooperative Family Registry for Breast Cancer studies
Source: Hum Mutat, 2002 Jul;20(1), p. 65-73.
Sample size requirements for matched case-control studies of gene-environment interaction.
Authors: Gauderman WJ
Source: Stat Med, 2002 Jan 15;21(1), p. 35-50.
Bias and efficiency in family-based gene-characterization studies: conditional, prospective, retrospective, and joint likelihoods.
Authors: Kraft P, Thomas DC
Source: Am J Hum Genet, 2000 Mar;66(3), p. 1119-31.