||3U01CA078296-05S4 Interpret this number
||University Of California Irvine
||NCI Cfrbccs Informatics Center at Uci
DESCRIPTION: Advanced technology for mutation detection, the cloning of
several cancer susceptibility genes, and high-throughput sequencing of genes
make obsolete many of the previous and some of the current research
strategies in the genetic epidemiology of cancer. In addition, the clinical
implications of inherited mutations will need to be defined and communicated
to health care providers and cancer genetics professionals. To provide an
infrastructure for studies in human cancer genetics of unprecedented size
and complexity, the National Cancer Institute has initiated the Cooperative
Family Registry for Breast and Colon Cancer Studies (CFRBCCS). Integral to
this effort will be a state-of-the-art Informatics Center (IC), that will
develop, implement, and maintain a central informatics system and provide
technical expertise for the development of information technologies,
statistical methodology, and study design. Collectively, the University of
California at Irvine (UCI), Dartmouth Medical School, and the University of
Southern California have extensive experience in developing information
management systems, participating in and coordinating multi-center research
efforts, and developing advanced techniques in biostatistics. Further,
leading international experts in biostatistics, genetic epidemiology, and
molecular genetics will participate as members in the Biostatistics,
Genetics, and Epidemiology Consortium, to provide technical expertise to
CFRBCCS researchers. Our specific aims are: 1) Develop, implement, and
maintain a single central informatics system at UCI, 2) Provide summary
data, support, and coordination for the CFRBCCS registries, 3) Provide
technical expertise regarding statistical issues, study design, methodology,
and information technologies for the Registries, through an international
consortium of leading experts in biostatistics, genetic epidemiology, and
molecular genetics, 4) Carry out the responsibility for the CFRBCCS
Study-wide communication, coordination, and administrative duties.
Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Kerber RA, Amos CI, Yeap BY, Finkelstein DM, Thomas DC
BMC Med Genet, 2008 Jul 10;9, p. 64.
2008 Jul 10.
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations.
Andrulis IL, Anton-Culver H, Beck J, Bove B, Boyd J, Buys S, Godwin AK, Hopper JL, Li F, Neuhausen SL, Ozcelik H, Peel D, Santella RM, Southey MC, van Orsouw NJ, Venter DJ, Vijg J, Whittemore AS, Cooperative Family Registry for Breast Cancer studies
Hum Mutat, 2002 Jul;20(1), p. 65-73.
Sample size requirements for matched case-control studies of gene-environment interaction.
Stat Med, 2002 Jan 15;21(1), p. 35-50.
Bias and efficiency in family-based gene-characterization studies: conditional, prospective, retrospective, and joint likelihoods.
Kraft P, Thomas DC
Am J Hum Genet, 2000 Mar;66(3), p. 1119-31.