Grant Details
Grant Number: |
3U01CA063731-10S1 Interpret this number |
Primary Investigator: |
Buist, Diana |
Organization: |
Group Health Cooperative |
Project Title: |
Breast Cancer Surveillance in a Defined Population |
Fiscal Year: |
2005 |
Abstract
DESCRIPTION: (Applicant's Description)
This proposed project takes advantage of comprehensive surveillance data on
more than 100,000 women offered breast cancer screening through a program with
mailed reminders to schedule mammography examinations within a managed care
plan (Group Health Cooperative of Puget Sound, GHC). Cancer outcome
(mortality, late-stage disease) for the target population are collected
through a Surveillance, Epidemiology, and End Results reporting (SEER)
registry and are linked to health care process data (service use, mammography
assessments). This proposal includes 3 specific aims: 1) To continue breast
cancer data system development at GHC to; a) improve data system software,
enhance data storage capabilities, and facilitate data retrieval; b)
incorporate new data components pertinent to research, such as a targeted
survey; and c) maintain and improve data quality assurance, report generation,
and data file development; 2) To use the data system to conduct 5 initiatives:
a) The effect of short-term hormone replacement therapy (HRT) cessation on
mammographic density; b) The likelihood of additional imaging (mammography and
ultrasound) and the associated costs among women stopping HRT compared to
women continuing or never using HRT; C) The factors that explain the reduced
sensitivity of mammography among younger women; d) The biologic and other
factors that influence the likelihood of late-stage disease; and, e) The
effect of screening interval on stage at-diagnosis; and 3) To conduct 5
research projects related to screening mammography: a) The additional effect
of mammographic breast density on the 5-year risk of breast cancer; b)
Screening sensitivity and specificity by phase of menstrual cycle; c) The
association between mammographic findings and cancer among women with
"probably benign findings"; d) The effect of computer assisted reading on
mammography interpretive performance; and e) Biomarkers associated with nodal
metastases at-diagnosis among screened women. By continuing our multi
disciplinary collaboration and using carefully designed prospective
observational and evaluative studies the investigators will contribute to
improvements in breast cancer screening, and the understanding of breast
cancer biology.
Publications
None. See parent grant details.