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Grant Details

Grant Number: 5R01CA077572-05 Interpret this number
Primary Investigator: Mctiernan, Anne
Organization: Fred Hutchinson Cancer Research Center
Project Title: Exercise Intervention in Colorectal Polyp Patients
Fiscal Year: 2004
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Abstract

DESCRIPTION (Adapted from the Applicant's Abstract): Strong observational evidence points to a link between physical activity and reduction in risk of colon cancer. The mechanisms for this association have not been delineated, nor have the amounts and types of exercise needed for a putative protective effect been determined. We propose a randomized controlled clinical trial of a one-year moderate aerobic/strength training exercise intervention in adenomatous colon polyp patients (n=100 men, 100 women). We hypothesize that polyp patients in an exercise intervention will experience significant biological effects on colorectal epithelium, specifically Ki67 indices of proliferation, bax and bc1-2 markers of apoptosis, and prostaglandin concentrations (PGE2 and PGF2cc). Patients will be recruited on-site from gastroenterology physicians' offices and secondarily from a high-risk colorectal cancer family registry. Sedentary individuals with newly diagnosed (within the past 18 months) adenomatous colon polyp(s) will be screened for eligibility and randomized to either the exercise intervention or a stretching-control group. The exercise intervention will use existing proven methods for adopting and maintaining exercise, taken from our ongoing research program. It will consist of 3 months' facility-based exercise instruction in small groups, followed by 9 months' home-based exercise program supplemented with group behavior change meetings. The goal for exercise will be moderate-level aerobic exercise 5-6 days per week for 30-45 minutes, plus strength training 2 days per week for 15-20 minutes. Colon and rectal biopsies will be taken at baseline and 12-months, and examined for amount and patterns of epithelial cell proliferation (with Ki67 marker) and apoptosis markers (bc1-2 and bax, an inhibitor and an inducer of apoptosis, respectively). Additional potential markers of exercise effect on colon cancer risk will be measured, including rectal mucosal biopsy prostaglandin concentrations, stool frequency, insulin-like growth factor (IGF-1) and IGF binding protein (IGFBP-3), insulin, glucose, C-peptide, triglycerides, and measures of fat mass and fat distribution. Other measures at baseline and 12 months include fitness (V02max), self-reported physical activity, diet, and quality of life. Results from this unique human experimental study will provide important information about mechanisms of exercise effects on colon carcinogenesis and about potential

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Publications

Effects of physical activity on melatonin levels in previously sedentary men and women.
Authors: Thrift AP, Xiao L, Patel SR, Tworoger SS, McTiernan A, Duggan C
Source: Cancer Epidemiol Biomarkers Prev, 2014 Aug;23(8), p. 1696-9.
EPub date: 2014 May 23.
PMID: 24859868
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Exercise adherence, cardiopulmonary fitness and anthropometric changes improve exercise self-efficacy and health-related quality of life.
Authors: Imayama I, Alfano CM, Mason CE, Wang C, Xiao L, Duggan C, Campbell KL, Foster-Schubert KE, Wang CY, McTiernan A
Source: J Phys Act Health, 2013 Jul;10(5), p. 676-89.
EPub date: 2012 Oct 4.
PMID: 23036856
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No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial.
Authors: Abrahamson PE, King IB, Ulrich CM, Rudolph RE, Irwin ML, Yasui Y, Surawicz C, Lampe JW, Lampe PD, Morgan A, Sorensen BE, Ayub K, Potter JD, McTiernan A
Source: Cancer Epidemiol Biomarkers Prev, 2007 Nov;16(11), p. 2351-6.
PMID: 18006923
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Exercise effect on weight and body fat in men and women.
Authors: McTiernan A, Sorensen B, Irwin ML, Morgan A, Yasui Y, Rudolph RE, Surawicz C, Lampe JW, Lampe PD, Ayub K, Potter JD
Source: Obesity (Silver Spring), 2007 Jun;15(6), p. 1496-512.
PMID: 17557987
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Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial.
Authors: McTiernan A, Yasui Y, Sorensen B, Irwin ML, Morgan A, Rudolph RE, Surawicz C, Lampe JW, Ayub K, Potter JD, Lampe PD
Source: Cancer Epidemiol Biomarkers Prev, 2006 Sep;15(9), p. 1588-97.
PMID: 16985018
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