Grant Details
| Grant Number: | 5R01CA082378-04 Interpret this number |
| Primary Investigator: | Phipps, Sean |
| Organization: | St. Jude Children'S Research Hospital |
| Project Title: | Measurement of Adaptive Style in Children with Cancer |
| Fiscal Year: | 2003 |
Abstract
Description (adapted from investigator's abstract): The construct of adaptive style provides a heuristic model for understanding the frequently reported findings of lower self-reports of psychological distress in children with cancer, in comparison to healthy children. Assessment of adaptive style allows for differentiation between truly low anxious individuals, who accurately report low levels of distress, and repressors, who maladaptively avoid the perception of negative affect of distress. In adults, repressive adaptation has been associated with altered patterns of physiological response to stress, and is related to numerous adverse health outcomes. Such relationships have not yet been studied in children. Recent studies have demonstrated a significantly higher incidence of repressors in children with cancer relative to healthy children, which accounts, in part, for the lower levels of distress by self-report in these children. Given the higher incidence of repressive adaptation in children with cancer, adaptive style may be a particularly important predictor of health outcomes in this population. The present proposal aims to improve measurement of adaptive style in children by combining self-report and psychophysiological assessment techniques, while examining the clinical significance of adaptive style in children undergoing treatment for cancer. The specific aims of the project are: 1) To determine the physiological concomitants of adaptive style in healthy children and children with cancer; 2) To assess the concordance in measurement of adaptive style by self-report and physiological indices; and 3) to determine the relationship of adaptive style to tolerance of anti-cancer therapy in children with recently diagnosed malignancies. These aims will be accomplished through two related studies. Study 1 will use a two group, case control design, pairing children who have completed treatment for cancer with healthy children matched on age, race, and gender. Participants will complete a battery of self report measures assessing adaptive style and then undergo physiological monitoring (heart rate, blood pressure, muscle tension, skin conductance, salivary cortisol) in a laboratory stress assessment task. Study 2 utilizes a single group, short term longitudinal design to determine the significance of adaptive style as a predictor of tolerance to anti-cancer therapy in terms of treatment side effects, acute toxicities and medical complications. Newly diagnosed pediatric cancer patients will undergo an identical procedure of self-report measures, stress tasks, and physiological assessment to assess adaptive style, and then be followed prospectively for 6 months while on active therapy. This study will advance knowledge regarding adaptive style in children, which can help to improve identification of truly distressed and non-distressed children, as well as those who may be at high risk for adverse healthy outcomes as a function of adaptive style.
Publications
Adaptive style and physiological reactivity during a laboratory stress paradigm in children with cancer and healthy controls.
Authors: Williams NA, Allen MT, Phipps S
Source: J Behav Med, 2011 Oct;34(5), p. 372-80.
EPub date: 2011 Feb 9.
PMID: 21305350
Related Citations
Grant Numbers:
| NCI NIH HHS - CA82378 |
MeSH Terms:
Optimism and pessimism in children with cancer and healthy children: confirmatory factor analysis of the youth life orientation test and relations with health-related quality of life.
Authors: Williams NA, Davis G, Hancock M, Phipps S
Source: J Pediatr Psychol, 2010 Jul;35(6), p. 672-82.
EPub date: 2009 Oct 1.
PMID: 19797406
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA82378 |
MeSH Terms:
| Questionnaires | Chi-Square Distribution | Humans |
| Health Status | Quality of Life | Child |
| Factor Analysis, Statistical | Neoplasms | Adaptation, Psychological |
| Affect | Adolescent | Survivors |
| Female | Male |
Brief report: Children's response to serious illness: perceptions of benefit and burden in a pediatric cancer population.
Authors: Currier JM, Hermes S, Phipps S
Source: J Pediatr Psychol, 2009 Nov-Dec;34(10), p. 1129-34.
EPub date: 2009 Apr 2.
PMID: 19342537
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA82378 |
MeSH Terms:
Symptoms of post-traumatic stress in children with cancer: does personality trump health status?
Authors: Phipps S, Jurbergs N, Long A
Source: Psychooncology, 2009 Sep;18(9), p. 992-1002.
PMID: 19177432
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA082378-02 | NCI NIH HHS - R01 CA082378-03 | NCI NIH HHS - R01 CA082378-04 |
| NCI NIH HHS - R01 CA82378 | NCI NIH HHS - R01 CA082378-01A1 |
MeSH Terms:
Stressful life events and posttraumatic stress symptoms in children with cancer.
Authors: Currier JM, Jobe-Shields LE, Phipps S
Source: J Trauma Stress, 2009 Feb;22(1), p. 28-35.
PMID: 19117041
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA082378-04 | NCI NIH HHS - R0I CA82378 |
MeSH Terms:
| United States | Regression Analysis | Neoplasms |
| Life Change Events | Risk Factors | Humans |
| Stress Disorders, Post-Traumatic | Child | Parents |
| Male | Female | Multivariate Analysis |
The Anger Expression Scale for Children: initial validation among healthy children and children with cancer.
Authors: Steele RG, Legerski JP, Nelson TD, Phipps S
Source: J Pediatr Psychol, 2009 Jan-Feb;34(1), p. 51-62.
EPub date: 2008 Jun 13.
PMID: 18556672
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA60616 | NCI NIH HHS - R01 CA82378 |
MeSH Terms:
Symptoms of posttraumatic stress in parents of children with cancer: are they elevated relative to parents of healthy children?
Authors: Jurbergs N, Long A, Ticona L, Phipps S
Source: J Pediatr Psychol, 2009 Jan-Feb;34(1), p. 4-13.
EPub date: 2007 Dec 11.
PMID: 18073235
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA82378 |
MeSH Terms:
Adaptive style in children with cancer: implications for a positive psychology approach.
Authors: Phipps S
Source: J Pediatr Psychol, 2007 Oct;32(9), p. 1055-66.
EPub date: 2007 Aug 14.
PMID: 17698880
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA82378 |
MeSH Terms:
| Neoplasms | Attitude to Health | Adaptation, Psychological |
| Humans | Repression, Psychology | Stress Disorders, Post-Traumatic |
| Child |
Benefit Finding Scale for Children: preliminary findings from a childhood cancer population.
Authors: Phipps S, Long AM, Ogden J
Source: J Pediatr Psychol, 2007 Nov-Dec;32(10), p. 1264-71.
EPub date: 2007 Jan 7.
PMID: 17210581
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA82378 |
MeSH Terms:
Self-report of somatic symptoms in survivors of childhood cancer: effects of adaptive style.
Authors: Jurbergs N, Long A, Hudson M, Phipps S
Source: Pediatr Blood Cancer, 2007 Jul;49(1), p. 84-9.
PMID: 16847928
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA82378 |
MeSH Terms:
Adaptive style and symptoms of posttraumatic stress in children with cancer and their parents.
Authors: Phipps S, Larson S, Long A, Rai SN
Source: J Pediatr Psychol, 2006 Apr;31(3), p. 298-309.
EPub date: 2005 May 25.
PMID: 15917493
Related Citations
Grant Numbers:
| NCI NIH HHS - R0I CA82378 |
MeSH Terms:
Commentary: contexts and challenges in pediatric psychosocial oncology research: chasing moving targets and embracing "good news" outcomes.
Authors: Phipps S
Source: J Pediatr Psychol, 2005 Jan-Feb;30(1), p. 41-5.
PMID: 15610983
Related Citations
Grant Numbers:
| NCI NIH HHS - R01 CA60616 | NCI NIH HHS - R01 CA82378 |
MeSH Terms:
| Neoplasms | Disease-Free Survival | Pediatrics |
| Humans | Social Support | Medical Oncology |
| Child | Research |
