Grant Details
Grant Number: |
3U01CA074799-04S1 Interpret this number |
Primary Investigator: |
Haile, Robert |
Organization: |
University Of Southern California |
Project Title: |
Colorectal Cancer Family Registry |
Fiscal Year: |
2001 |
Abstract
DESCRIPTION: (Applicant's Description)
The objective is to establish a registry of families with multiple cases of
colorectal cancer. Specific aims are: 1) Contact cases of colorectal
cancer in participating population-based cancer registries and identify
cases with a positive family history of colorectal cancer. The applicant
proposes to contact 50 percent of White cases diagnosed in 1996/97 (2-year
period). The applicant also proposes contacting 100 percent of
African-American, Asian, and Hispanic families and cases diagnosed under 50
years of age for a period of four years. Over 1,200 families with two cases
of colorectal cancer and about 400 with at least three cases of colorectal
cancer will be identified. 2) Supplement this population-based series of
families with a large registry of 382 families with FAP (3,250 subjects) and
100 (Amsterdam criteria) HNPCC families (900 subjects) and 250 HNPCC-like
families (2,250 subjects) identified by the Cleveland Clinic. 3) For
families identified from the population-based registries, maintain a file
with contact information on 10 percent of sporadic cases and all families
with two cases of colorectal cancer (due to cost constraints, additional
data collection for these families is not proposed at this time). For
families with three or more cases of colorectal cancer, the applicant
proposes to use a case-unaffected sibling or cousin control design to define
subjects on whom to collect additional data, including: a) food frequency
questionnaire, with a supplement to obtain additional information on
exposure to heterocyclic amines by computer assisted telephone interviews
(CATI); b) a risk factor questionnaire that will focus on physical activity,
NSAIDs, smoking, alcohol, and hormones, obtained by CATI; c) blood sample;
d) for cases of colorectal cancer (and other cancers of interest), pathology
reports and tumor blocks. 4) For families in the FAP/HNPCC registry at the
Cleveland Clinic, collect additional data as described above for cases,
unaffected siblings and cousins, and other selected relatives. 5) Develop a
highly efficient system for managing these data. 6) Provide genetic
counseling services. 7) Collaborate with the other centers of the CFRCCS.
An important aspect of this application is that all investigators have
agreed in principle that the study design may be amended and priorities
shifted (e.g., targeting certain subgroups defined by age, race or other
variables) and budgets revised accordingly in response to decisions made by
the CFRCCS.
Publications
None. See parent grant details.