Grant Details
Grant Number: |
3U01CA074806-04S1 Interpret this number |
Primary Investigator: |
Le Marchand, Loic |
Organization: |
University Of Hawaii At Manoa |
Project Title: |
Hawaii Family Registry of Colon Cancer |
Fiscal Year: |
2001 |
Abstract
DESCRIPTION: (Applicant's Description)
This application, to participate in the Cooperative Family Registry of Colon
Cancer, capitalizes on the applicant's experience in conducting family
studies of colorectal cancer (CRC) in Hawaii, on the unique access to
under-served and understudied ethnic minorities at high and low risks for
CRC, as well as on characteristics of Hawaii's population which make it
eminently suitable for genetic epidemiology (remoteness, stability, large
pedigrees, population registries, good compliance). This new initiative
also builds on several NIH-supported, population-based research projects on
environmental and genetic factors and attitudes toward genetic testing for
CRC. The aims of this application are: 1) to establish a family registry
and bio-repository for high-risk families in Hawaii and to contribute data
and specimens for about 130 new intermediate and high risk families for CRC
(an additional 140 families from the current family study will also be
contributed after publication of results); 2) to develop and pilot test
protocols using the Cooperative Family Registry: a) to describe the
mutational spectra and clinical characteristics of known hereditary
syndromes of CRC in ethnic populations, b) to assess the penetrance of
relevant mutations in individuals of various ethnic backgrounds, c) to
conduct intervention studies among high risk individuals with regard to
early detection, diet and exercise, d) to study psychological issues related
to high familial risk and predictive genetic testing. All new incident
cases of CRC on the island Oahu for 1997-2000 (n=2,280) will be screened for
family history of CRC among first degree relatives. Patients with one or
more first degree relatives with CRC and their relatives will be included in
the registry. Selected second degree relatives will also be included for
some multicase families. Data on personal and familial history of cancer
and on environmental risk factors will be collected from each participant,
as well as a blood sample and tumor blocks. Selected long-term benefits of
this research include data on the molecular genetic epidemiology of CRC, as
well as on the acceptability of predictive genetic testing for CRC in ethnic
groups, including Native Hawaiians and Japanese, that are difficult to study
anywhere else in the United States and the invaluable research insights that
may result from cross-ethnic and cross-cultural comparisons.
Publications
None. See parent grant details.