Grant Details
Grant Number: |
3U01CA074783-04S1 Interpret this number |
Primary Investigator: |
Gallinger, Steven |
Organization: |
Cancer Care Ontario |
Project Title: |
Ontario Registry for Studies of Familial Colon Cancer |
Fiscal Year: |
2001 |
Abstract
DESCRIPTION: (Applicant's Description)
The general objective of this application is to develop a population-based
colorectal cancer (CRC) family registry resource, with epidemiologic data
and a biologic tissue bank, from CRC patients in Ontario, Canada. The
registry will be a contributor to the consortium of such registries planned
by the National Institutes of Health (NIH) that will be used for
epidemiologic studies, primary prevention trials, gene discovery; for the
investigation of gene environment interactions; and for the evaluation of
surveillance protocols and treatment interventions in high risk CRC families
as part of a Co-operative Agreement with other family registries.
This objective will be met by building on existing infrastructure and
experience developed by co-investigators participating in the activities of
the previously awarded Co-operative Family Registry for Breast Cancer
Studies (CFRBCS), with which the CRC registry proposed here will be
integrated. Further, the proposed Co-operative Family Registry for Colon
Cancer Studies (CFRCCS) will take advantage of established resources, in
particular the Ontario Cancer Genetics Network (OCGN) and the
population-based Ontario Cancer Registry (OCR). The applicant plans to
compile family history data for all eligible CRC cases in Ontario who will
serve as probands, and family history information will be used to define
cohorts of high risk according to the Amsterdam criteria and intermediate
risk and sporadic cases and their families. Epidemiologic data, CRC
treatment data and biologic tissues will be obtained from all high and
intermediate risk probands and their families, from a random sample of
sporadic cases (and a subsample of their families), and from population
controls and a sample of their families.
The frequency and nature of mutations in genes involved in hereditary
predisposition to colon cancer in high and intermediate risk families will
be determined. Molecular diagnostic testing will be performed on specimens
from probands in these risk groups. The populations with hereditary
predisposition to CRC identified by these activities will be potential
participants in trials that evaluate new prevention and therapeutic
strategies.
Publications
None. See parent grant details.