Grant Number:	5P50DA013332-03 Interpret this number
Primary Investigator:	Leslie, Frances
Organization:	University Of California Irvine
Project Title:	Center on Tobacco Use Susceptibility and Intervention
Fiscal Year:	2001

The proposed TTURC reflects several unique strengths. First, the Center brings together five eminent project leaders with diverse expertise in the field of tobacco research (Drs. Leslie, Janner, PotInn, Pechman, and Tengs). Each of these scholars has achieved distinction in their respective disciplines of pharmacology, neuroscience, human development, social and health psychology, community health promotion, and health policy analysis. These scientists will work collaboratively to identify key predictor of nicotine dependency in animals and tobacco susceptibility and use in humans. A major goal of the collaboration is to establish a shared conceptual model of tobacco susceptibility and use that can be used to integrate experimental findings across multiple levels of analysis (i.e., biological, behavioral, developmental, interpersonal, and epidemiological/community levels), and to translate these findings into intervention strategics (i.e., pharmacological, behavioral, social marketing, and health policy strategies) that will be evaluated for their public health efficacy and cost effectiveness. A second major strength of the TTURC is its incorporation of four highly interactive cores, each strategically designed to promote successful transdisciplinary collaboration in the field of tobacco susceptibility, use, and intervention. The Transdisciplinary Core will implement structured activities to foster scientific collaboration (e.g., team workshops, retreats), and also conduct a systematic self study of collaboration among members of the TIURC over a five-year period, based on a taxonomic model of the antecedents, intermediate processes, and scientific outcomes of transdisciplinary research. The Informatics Core (led by Dr. Shankle) will develop several valuable informational resources, including a shared relational data base to facilitate the integration of data sets and research findings across multiple TTURC projects and an interactive TTURC web site), all designed to promote more effective transdisciplinary collaboration The Career Development Core (co-directed by Drs. Whitely and Fallon) integrates the theoretical and methodological perspectives emphasized in the research projects and the Transdisciplinary, and Informatics Cores. It will afford a wide array of transdisciplinary training opportunities that are directly responsive to the training priorities outlined in the Report of the Working Groups of the Youth Tobacco Prevention Initiative (1998). Finally, the Administrative Core will be co-directed by Drs. Leslie and Stokols, both of whom have extensive university administrative experience and are active in the fields of pharmacology, neuro5cience, community health promotion, social ecology, and transdisciplinary theory development. The CO-PIs will oversee interactive activities of the TTURC with the goal of promoting effective transdisciplinary collaboration among the project team members research trainees and staff and members of the External and Internal Advisory Boards.




Smoking to self-medicate attentional and emotional dysfunctions.
Authors: Gehricke J.G. , Loughlin S.E. , Whalen C.K. , Potkin S.G. , Fallon J.H. , Jamner L.D. , Belluzzi J.D. , Leslie F.M. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2007 Nov; 9 Suppl 4, p. S523-36.
PMID: 18067030
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Limiting youth access to tobacco: comparing the long-term health impacts of increasing cigarette excise taxes and raising the legal smoking age to 21 in the United States.
Authors: Ahmad S. , Billimek J. .
Source: Health Policy (amsterdam, Netherlands), 2007 Mar; 80(3), p. 378-91.
PMID: 16698112
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Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine.
Authors: Villégier A.S. , Salomon L. , Granon S. , Changeux J.P. , Belluzzi J.D. , Leslie F.M. , Tassin J.P. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2006 Aug; 31(8), p. 1704-13.
PMID: 16395299
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The reinforcing effects of nicotine and stimulant medication in the everyday lives of adult smokers with ADHD: A preliminary examination.
Authors: Gehricke J.G. , Whalen C.K. , Jamner L.D. , Wigal T.L. , Steinhoff K. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2006 Feb; 8(1), p. 37-47.
PMID: 16497598
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Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
Authors: Belluzzi J.D. , Wang R. , Leslie F.M. .
Source: Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology, 2005 Apr; 30(4), p. 705-12.
PMID: 15496937
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Adolescent development of forebrain stimulant responsiveness: insights from animal studies.
Authors: Leslie F.M. , Loughlin S.E. , Wang R. , Perez L. , Lotfipour S. , Belluzzia J.D. .
Source: Annals Of The New York Academy Of Sciences, 2004 Jun; 1021, p. 148-59.
PMID: 15251884
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Is there a link between adolescent cigarette smoking and pharmacotherapy for ADHD?
Authors: Whalen C.K. , Jamner L.D. , Henker B. , Gehricke J.G. , King P.S. .
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2003 Dec; 17(4), p. 332-5.
PMID: 14640830
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Tobacco use across the formative years: a road map to developmental vulnerabilities.
Authors: Jamner L.D. , Whalen C.K. , Loughlin S.E. , Mermelstein R. , Audrain-McGovern J. , Krishnan-Sarin S. , Worden J.K. , Leslie F.M. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2003 Dec; 5 Suppl 1, p. S71-87.
PMID: 14668088
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Gender specific effect of neonatal handling on stress reactivity of adolescent rats.
Authors: Park M.K. , Hoang T.A. , Belluzzi J.D. , Leslie F.M. .
Source: Journal Of Neuroendocrinology, 2003 Mar; 15(3), p. 289-95.
PMID: 12588518
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Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Authors: Solbrig M.V. , Koob G.F. .
Source: Pharmacology, Biochemistry, And Behavior, 2003 Mar; 74(4), p. 777-87.
PMID: 12667891
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Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons.
Authors: Azam L. , Winzer-Serhan U. , Leslie F.M. .
Source: Neuroscience, 2003; 119(4), p. 965-77.
PMID: 12831856
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Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception.
Authors: Lin S.H. , Leslie F.M. , Civelli O. .
Source: Brain Research, 2002-10-11 00:00:00.0; 952(1), p. 15-30.
PMID: 12363400
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Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons.
Authors: Azam L. , Winzer-Serhan U.H. , Chen Y. , Leslie F.M. .
Source: The Journal Of Comparative Neurology, 2002-03-12 00:00:00.0; 444(3), p. 260-74.
PMID: 11840479
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Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo.
Authors: Hilgenberg L.G. , Ho K.D. , Lee D. , O'Dowd D.K. , Smith M.A. .
Source: Molecular And Cellular Neurosciences, 2002 Jan; 19(1), p. 97-110.
PMID: 11817901
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The ADHD spectrum and everyday life: experience sampling of adolescent moods, activities, smoking, and drinking.
Authors: Whalen C.K. , Jamner L.D. , Henker B. , Delfino R.J. , Lozano J.M. .
Source: Child Development, 2002 Jan-Feb; 73(1), p. 209-27.
PMID: 14717253
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The cost-effectiveness of intensive national school-based anti-tobacco education: results from the tobacco policy model.
Authors: Tengs T.O. , Osgood N.D. , Chen L.L. .
Source: Preventive Medicine, 2001 Dec; 33(6), p. 558-70.
PMID: 11716651
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Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain.
Authors: Saito Y. , Cheng M. , Leslie F.M. , Civelli O. .
Source: The Journal Of Comparative Neurology, 2001-06-18 00:00:00.0; 435(1), p. 26-40.
PMID: 11370009
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