|Grant Number:||5R21CA088293-02 Interpret this number|
|Primary Investigator:||Lutgendorf, Susan|
|Organization:||University Of Iowa|
|Project Title:||Biobehavioral Immune Interactions in Ovarian Cancer|
DESCRIPTION: (Applicant's Description) Ovarian cancer is the second most common gynecologic cancer. Because of low rates of survival for the majority of women with ovarian cancer, identification of potential factors contributing to compromised or enhanced host resistance at the earliest possible stage (pre-treatment) can increase understanding of factors that may influence disease progression and survival. The proposed project is designed to examine the relationship of stress, depression, social support, and coping in 112 women at the time of surgical diagnosis for ovarian cancer. This project is innovative in several ways. 1) We will investigate whether the behavioral-immune relationships reported in other cancers are present among women with ovarian cancers. 2) We will be using a surgery model that will allow us to examine activity of lymphocytes from peripheral blood against autologous tumor cells, as well as cytolytic activity of cells from within the tumor itself and from the ascites (fluid around the tumor). This will allow us not only to examine relationships of psychosocial variables with peripheral blood cells which likely are important in surveillance against tumor cells, but will also allow us to examine whether these relationships are present in the local environment of the tumor where inter-cell communication and cytotoxic activity is of primary importance. 3) We will be using a very sensitive and quantitative flow cytometric method to identify tumor antigen-specific CD4+ and CDS+ cells. We will look at non-specific and specific aspects of the immune response, as both are relevant to ovarian cancer. 4) We will also examine whether these behavioral-immune relationships are mediated by dysregulation in the neuroendocrine hormone cortisol. The significance of the project is that a clearer understanding of behavioral-immune mechanisms in ovarian cancer may enable the identification of biobehavioral risk factors for cancer progression that will be useful in cancer control and as targets of future intervention strategies.
Diurnal cortisol and survival in epithelial ovarian cancer.
Authors: Schrepf A, Thaker PH, Goodheart MJ, Bender D, Slavich GM, Dahmoush L, Penedo F, DeGeest K, Mendez L, Lubaroff DM, Cole SW, Sood AK, Lutgendorf SK
Source: Psychoneuroendocrinology, 2015 Mar;53, p. 256-67.
EPub date: 2015 Jan 20.
Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year after diagnosis.
Authors: Clevenger L, Schrepf A, Degeest K, Bender D, Goodheart M, Ahmed A, Dahmoush L, Penedo F, Lucci J 3rd, Thaker PH, Mendez L, Sood AK, Slavich GM, Lutgendorf SK
Source: Cancer, 2013 Sep 1;119(17), p. 3234-41.
EPub date: 2013 Jun 24.
Social influences on clinical outcomes of patients with ovarian cancer.
Authors: Lutgendorf SK, De Geest K, Bender D, Ahmed A, Goodheart MJ, Dahmoush L, Zimmerman MB, Penedo FJ, Lucci JA 3rd, Ganjei-Azar P, Thaker PH, Mendez L, Lubaroff DM, Slavich GM, Cole SW, Sood AK
Source: J Clin Oncol, 2012 Aug 10;30(23), p. 2885-90.
EPub date: 2012 Jul 16.
Biobehavioral factors and cancer progression: physiological pathways and mechanisms.
Authors: Lutgendorf SK, Sood AK
Source: Psychosom Med, 2011 Nov-Dec;73(9), p. 724-30.
EPub date: 2011 Oct 21.
Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients.
Authors: Lutgendorf SK, DeGeest K, Dahmoush L, Farley D, Penedo F, Bender D, Goodheart M, Buekers TE, Mendez L, Krueger G, Clevenger L, Lubaroff DM, Sood AK, Cole SW
Source: Brain Behav Immun, 2011 Feb;25(2), p. 250-5.
EPub date: 2010 Oct 16.
Care of the caregiver: stress and dysregulation of inflammatory control in cancer caregivers.
Authors: Lutgendorf SK, Laudenslager ML
Source: J Clin Oncol, 2009 Jun 20;27(18), p. 2894-5.
EPub date: 2009 May 11.
Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma.
Authors: Lutgendorf SK, Lamkin DM, Jennings NB, Arevalo JM, Penedo F, DeGeest K, Langley RR, Lucci JA 3rd, Cole SW, Lubaroff DM, Sood AK
Source: Clin Cancer Res, 2008 Nov 1;14(21), p. 6839-46.
Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients.
Authors: Lutgendorf SK, Weinrib AZ, Penedo F, Russell D, DeGeest K, Costanzo ES, Henderson PJ, Sephton SE, Rohleder N, Lucci JA 3rd, Cole S, Sood AK, Lubaroff DM
Source: J Clin Oncol, 2008 Oct 10;26(29), p. 4820-7.
EPub date: 2008 Sep 8.
Depression, social support, and beta-adrenergic transcription control in human ovarian cancer.
Authors: Lutgendorf SK, DeGeest K, Sung CY, Arevalo JM, Penedo F, Lucci J 3rd, Goodheart M, Lubaroff D, Farley DM, Sood AK, Cole SW
Source: Brain Behav Immun, 2009 Feb;23(2), p. 176-83.
EPub date: 2008 Jun 11.
Social support, psychological distress, and natural killer cell activity in ovarian cancer.
Authors: Lutgendorf SK, Sood AK, Anderson B, McGinn S, Maiseri H, Dao M, Sorosky JI, De Geest K, Ritchie J, Lubaroff DM
Source: J Clin Oncol, 2005 Oct 1;23(28), p. 7105-13.
Quality of life and mental health in cervical and endometrial cancer survivors.
Authors: Bradley S, Rose S, Lutgendorf S, Costanzo E, Anderson B
Source: Gynecol Oncol, 2006 Mar;100(3), p. 479-86.
EPub date: 2005 Sep 26.
Psychosocial factors and interleukin-6 among women with advanced ovarian cancer.
Authors: Costanzo ES, Lutgendorf SK, Sood AK, Anderson B, Sorosky J, Lubaroff DM
Source: Cancer, 2005 Jul 15;104(2), p. 305-13.
Mood and cytokine response to influenza virus in older adults.
Authors: Costanzo ES, Lutgendorf SK, Kohut ML, Nisly N, Rozeboom K, Spooner S, Benda J, McElhaney JE
Source: J Gerontol A Biol Sci Med Sci, 2004 Dec;59(12), p. 1328-33.
Vascular endothelial growth factor and social support in patients with ovarian carcinoma.
Authors: Lutgendorf SK, Johnsen EL, Cooper B, Anderson B, Sorosky JI, Buller RE, Sood AK
Source: Cancer, 2002 Aug 15;95(4), p. 808-15.