Grant Number:	5P50CA084944-03 Interpret this number
Primary Investigator:	Antoni, Michael
Organization:	University Of Miami Coral Gables
Project Title:	Center for Psycho-Oncology Research
Fiscal Year:	2001

This application is for a 5-year Center for Psycho-Oncology Research (CPOR) grant to conduct behavioral, psychological, social, and biomedical research on the interrelationships among cognition, emotion, biological processes, and physical health in patients with different forms of cancer including breast cancer, prostate cancer and AIDS-related cervical neoplasia. The Center will systematically evaluate the efficacy group-based Cognitive Behavioral Stress Management (CBSM) intervention in Projects 1, 2 and 3., and a pharmacological hormonal treatment in Project 4, for improving quality of life and physical health in patients with different types of cancer or carcinogenic processes associated with reproductive health or hormonal functioning. These include women with breast cancer, older men with prostate cancer, and women at high risk for cervical cancer due to co-infection with Human Immunodeficiency Virus (HIV+) AND Human Papillomavirus (HPV+). Our prior work has shown that CBSM intervention can improve mood, change cognitions and build coping resources; that it modulates the output of sympathetic nervous system (SNS), Hypothalamic Pituitary Adrenal (HPA), and Hypothalamic Pituitary Gonadal (HPG) hormones; and that it helps normalize immunologic status in different populations. The Center will directly address these issues through four (4) randomized clinical trials as follows. Project 1 will (a) evaluate the effects of CBSM intervention on psychological distress, quality of life and biopsy- determined level of cervical cellular atypia; and (b) examine the putative psycho-biological mediators (psychosocial, endocrine, and immunologic changes) on intervention effects observed. Project 2 will (a) investigate the effects of CBSM intervention and quality of life and disease status (change in CA15-3) antigen levels) in women with early-mid stage breast, and (b) examine the putative psycho-biological mediators of intervention effects observed. Project 3 will (a) investigate the effects of CBSM in combination with Viagra (sildenafil citrate) on quality of life and physical health in older men with prostate cancer, and (b) examine the putative psycho-biological mediators of intervention effects observed. Project 4 will (a) evaluate the effects of estrogen therapy (chronic low-dose oral 17- beta estradiotherapy) on mood and quality of life, and physical health in patients with metastatic prostate cancer, and (b) examine the putative psycho-biological mediators of intervention effects observed. The Center will also support and conduct pilot studies of interventions in men and women with other cancers, and will also develop and test other forms of intervention as well as Spanish translations of CBSM for Spanish- speaking Breast and Prostate cancer patients.




Millon Behavioral Medicine Diagnostic (MBMD) Predicts Health-Related Quality of Life (HrQoL) over time among men treated for localized prostate cancer.
Authors: Cruess D.G. , Benedict C. , Lattie E.G. , Molton I. , Kinsinger D. , Kava B. , Manoharan M. , Soloway M. , Penedo F.J. .
Source: Journal Of Personality Assessment, 2013; 95(1), p. 54-61.
PMID: 22571442
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Self-regulation processes and health: the importance of optimism and goal adjustment.
Authors: Rasmussen H.N. , Wrosch C. , Scheier M.F. , Carver C.S. .
Source: Journal Of Personality, 2006 Dec; 74(6), p. 1721-47.
PMID: 17083664
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Quality of life among long-term survivors of breast cancer: Different types of antecedents predict different classes of outcomes.
Authors: Carver C.S. , Smith R.G. , Petronis V.M. , Antoni M.H. .
Source: Psycho-oncology, 2006 Sep; 15(9), p. 749-58.
PMID: 16304622
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Enhancing adaptation during treatment and the role of individual differences.
Authors: Carver C.S. .
Source: Cancer, 2005-12-01 00:00:00.0; 104(11 Suppl), p. 2602-7.
PMID: 16247785
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Optimistic personality and psychosocial well-being during treatment predict psychosocial well-being among long-term survivors of breast cancer.
Authors: Carver C.S. , Smith R.G. , Antoni M.H. , Petronis V.M. , Weiss S. , Derhagopian R.P. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2005 Sep; 24(5), p. 508-16.
PMID: 16162045
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Perceived partner reactions to diagnosis and treatment of breast cancer: impact on psychosocial and psychosexual adjustment.
Authors: Wimberly S.R. , Carver C.S. , Laurenceau J.P. , Harris S.D. , Antoni M.H. .
Source: Journal Of Consulting And Clinical Psychology, 2005 Apr; 73(2), p. 300-11.
PMID: 15796638
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Finding benefit in breast cancer during the year after diagnosis predicts better adjustment 5 to 8 years after diagnosis.
Authors: Carver C.S. , Antoni M.H. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2004 Nov; 23(6), p. 595-8.
PMID: 15546227
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Negative affects deriving from the behavioral approach system.
Authors: Carver C.S. .
Source: Emotion (washington, D.c.), 2004 Mar; 4(1), p. 3-22.
PMID: 15053723
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Physical activity interventions in the elderly: cancer and comorbidity.
Authors: Penedo F.J. , Schneiderman N. , Dahn J.R. , Gonzalez J.S. .
Source: Cancer Investigation, 2004; 22(1), p. 51-67.
PMID: 15069763
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Adaptive self-regulation of unattainable goals: goal disengagement, goal reengagement, and subjective well-being.
Authors: Wrosch C. , Scheier M.F. , Miller G.E. , Schulz R. , Carver C.S. .
Source: Personality & Social Psychology Bulletin, 2003 Dec; 29(12), p. 1494-508.
PMID: 15018681
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Dispositional pessimism predicts illness-related disruption of social and recreational activities among breast cancer patients.
Authors: Carver C.S. , Lehman J.M. , Antoni M.H. .
Source: Journal Of Personality And Social Psychology, 2003 Apr; 84(4), p. 813-21.
PMID: 12703650
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Perceived stress management skill mediates the relationship between optimism and positive mood following radical prostatectomy.
Authors: Penedo F.J. , Dahn J.R. , Gonzalez J.S. , Molton I. , Carver C.S. , Antoni M.H. , Roos B.A. , Schneiderman N. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2003 Mar; 22(2), p. 220-2.
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Resolved: psychosocial interventions can improve clinical outcomes in organic disease (pro).
Authors: Williams R.B. , Schneiderman N. .
Source: Psychosomatic Medicine, 2002 Jul-Aug; 64(4), p. 552-7.
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