Grant Details
Grant Number: |
5R01CA081595-04 Interpret this number |
Primary Investigator: |
Beckham, Jean |
Organization: |
Duke University |
Project Title: |
Smoking and Anxiety in Posttraumatic Stress Disorder |
Fiscal Year: |
2001 |
Abstract
The relationship between anxiety and smoking in high-risk subgroups, such
as patients with Post-traumatic Stress Disorder (PTSD), has received
little empirical attention. Preliminary research indicates that 60% of
PTSD combat veterans smoke, and that during a laboratory stressor, PTSD
patients report greater smoking withdrawal symptoms in response to trauma-
related Stroop cards. These results suggest that trauma-related material
may serve as a cue for smoking in PTSD combat veterans. The first purpose
of this proposal is to determine whether increased craving for cigarettes
after Vietnam words occurs in veterans with PTSD as compared to veterans
without PTSD or GAD patients, and whether PTSD patient groups experience
greater relief from their symptoms, including PTSD reexperiencing and
hyper-arousal symptoms after smoking. A well-established script-driven
imagery procedure will be utilized to examine the effect of different
scripts (disorder-related, general stress, neutral) across study groups,
and the effect of nicotine on symptom reduction. The second purpose of
this proposal is to explore the link between anxiety and smoking in the
natural environment by comparing study groups. Subjects will monitor their
smoking using an ambulatory heart rate monitor and diary. Besides
potentially confirming parallel laboratory and real-world data on a
relationship between anxiety and smoking, a naturalistic observation study
will allow examination of whether the association between smoking and
anxiety is due to other circumstances which co-occur with both anxiety and
smoking. The ultimate goal of this research is to identify risk factors in
subgroups of smokers who are at risk for increased smoking and difficulty
in smoking cessation that could lead to important prevention and
intervention efforts.
Publications
MMPI-2 profiles of Gulf and Vietnam combat veterans with chronic posttraumatic stress disorder.
Authors: Glenn D.M.
, Beckham J.C.
, Sampson W.S.
, Feldman M.E.
, Hertzberg M.A.
, Moore S.D.
.
Source: Journal of clinical psychology, 2002 Apr; 58(4), p. 371-81.
PMID: 11920691
Related Citations
Smoking and anxiety in combat veterans with chronic posttraumatic stress disorder: a review.
Authors: Beckham J.C.
.
Source: Journal of psychoactive drugs, 1999 Apr-Jun; 31(2), p. 103-10.
PMID: 10437991
Related Citations