Grant Details
Grant Number: |
3P01CA042792-13S1 Interpret this number |
Primary Investigator: |
Mc Dougall, James |
Organization: |
Fred Hutchinson Cancer Research Center |
Project Title: |
HPV-Biology Clinical Significance and Epidemiology |
Fiscal Year: |
2000 |
Abstract
We propose to continue multidisciplinary studies of the role of human
papillomaviruses (HPV) in the etiology of anogenital cancers. The nucleus
of this effort is a series of case-control studies which address the risk-
factors involved in squamous cell cervical cancer, anal cancer, vulvar
cancer, vaginal cancer adenocarcinoma of the cervix and penile cancer.
Eligible subjects will be those diagnosed with one of these cancers
between July 1994 through June 1998 together with appropriate controls.
Results from these studies will add to the data base accumulated over the
previous 8 years of this Program Project. In the previous years of this
program the main focus has been on HPV and although that focus will be
continued we now place equal stress on other factors involved in the
etiology of these cancers. Tissue specimens will be tested for HPV and
biological markers affecting proliferation, prognosis and host
susceptibility. Blood samples will be collected for HPV serology and for
evidence of HSV-2 infection. Development of serological tests for HPV has
been one of the major accomplishments of this program and these will be
used to identify serological markers for HPV infection and tumor
progression or inhibition. These studies also form the basis for
developing an understanding of the immune response to HPV and the design
of therapeutic strategies. The cell-mediated response to HPV infection
will be investigated as will the potential role of HLA genotype. As with
most other cancers, anogenital cancer has the characteristics of a
multistep process to malignancy. The steps in this process will be
investigated in an effort to identify chromosomal regions in anogenital
cancers subject to non-random deletion, rearrangement or amplification.
These indicators of genetic instability will be analyzed for evidence of
oncogenes and tumor suppressor genes mapping in regions of chromosomal
abnormality. An extension of the case-control studies supported by this
Program Project into an evaluation of prognostic markers is timely, since
improvement in prognosis has not been evident in women diagnosed with
cervical cancer despite a decrease in mortality from this disease. An
analysis of tumor markers, as shown above, and HPV presence will be
conducted on tissue specimens from women diagnosed with anogenital cancer
between 1986 and 1996, in order to develop data which could be used to
define therapies.
Publications
None. See parent grant details.