Grant Details
Grant Number: |
5U01AI034989-08 Interpret this number |
Primary Investigator: |
Greenblatt, Ruth |
Organization: |
Univ Of California At San Francisco |
Project Title: |
Connie Wofsy Womens HIV Study |
Fiscal Year: |
2001 |
Abstract
The Connie Wofsy Women's HIV Study, the Northern California site of the
Women's Interagency HIV Study (WIHS), a multisite cohort study is
focused on the clinical, laboratory and psychosocial aspects of HIV
infection in women. In the first four years, an organized
infrastructure was created and interview, examination, and specimen data
collected. Initial recruitment at this site included 336 HIV+ and 91
HIV-women who are well matched in terms of age, race, and education.
The cohort is very diverse in terms of risk factors for acquisition of
HIV infection, race, and age and by these characteristics are highly
representative of women living with AIDS in the San Francisco Bay Area.
Analysis of baseline data is well underway; to date, 21 abstract
presentations and one published report have been completed. This WIHS
II proposal includes multisite core studies and site-specific
substudies. The core protocol tests specific hypotheses and creates a
repository of interview data and specimens that are available for
current and future substudies. These hypotheses take into consideration
advances in understanding the pathogenesis and treatment of HIV
infection. Core aims and objectives include investigations of 1) HIV
disease progression, 2) emergence of resistance to antiretroviral drugs,
3) the natural history of genital tract neoplasia and HPV infection, 4)
expression of HIV in the lower genital tract, 5) the association between
concurrent conditions and HIV disease progression, 6) malignancies and
related infections, 7) the oral cavity, 8) HIV seroconversion, and 9)
behavioral characteristics.
The proposed research designs and methods are both a continuation of
selected WIHS I activities (e.g. semiannual core follow-up visits), as
well as studies designed to answer new research questions (e.g.
laboratory testing for evidence of nucleoside and Indinavir resistance).
The overall structure of the WIHS is ideal for the support of nested
studies that utilize the extensive clinical database and specimen
repository.
Publications
None