Grant Number:	1R01CA087845-01A1 Interpret this number
Primary Investigator:	Ahles, Tim
Organization:	Dartmouth College
Project Title:	Cognitive Effects of Cancer Chemotherapy
Fiscal Year:	2001

APPLICANT'S DESCRIPTION: Cognitive deficits associated with cancer treatment can have a dramatic effect on patients' quality of life and have been recognized as a problem by the President's Cancer Panel (1999) and the National Coalition for Cancer Survivorship as a challenge facing people with cancer. The present application is an extension of work completed by researchers at Dartmouth with a supplement from the Office of Cancer Survivors to the Norris Cotton Cancer Center Core grant (Grant No. P30CA23 108, supplement) entitled "Cognitive Impact of Systemic Chemotherapy in Long-Term Survivors of Breast Cancer and Lymphoma." Survivors who were greater than 5 years post-diagnosis and disease free were administered a battery of standardized neuropsychological and psychological tests. The results demonstrated that survivors who had been treated with systemic chemotherapy scored significantly lower in overall neuropsychological functioning as compared to survivors who had been treated with local therapy only. In this next phase of research, we propose to prospectively study the cognitive deficits experienced by breast cancer and lymphoma patients treated with their first course of systemic chemotherapy versus local surgery or non-CNS radiation. Patients will be assessed at pre-treatment and 6, 12 and 24 months post-diagnosis with a standardized battery of neuropsychological and psychological tests. The primary hypothesis is that patients treated with systemic chemotherapy will demonstrate greater decrements in performance from pre- to post-treatment on standardized measures of neuropsychological functioning as compared to patients treated with local therapy only after controlling for important confounding variables such as age, education, and psychological state. Secondarily, we will evaluate the associations between cognitive functioning and other factors that may effect cognition in cancer patients including genetic markers (APOE status), metabolic factors, menopausal status (pre- vs. post-menopausal at diagnosis), and use of tamoxifen (breast cancer only).




Reliable change in neuropsychological assessment of breast cancer survivors.
Authors: Andreotti C. , Root J.C. , Schagen S.B. , McDonald B.C. , Saykin A.J. , Atkinson T.M. , Li Y. , Ahles T.A. .
Source: Psycho-oncology, 2016 Jan; 25(1), p. 43-50.
PMID: 25808921
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Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: the impact of APOE and smoking.
Authors: Ahles T.A. , Li Y. , McDonald B.C. , Schwartz G.N. , Kaufman P.A. , Tsongalis G.J. , Moore J.H. , Saykin A.J. .
Source: Psycho-oncology, 2014 Dec; 23(12), p. 1382-90.
PMID: 24789331
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Brain vulnerability to chemotherapy toxicities.
Authors: Ahles T.A. .
Source: Psycho-oncology, 2012 Nov; 21(11), p. 1141-8.
PMID: 23023994
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Cancer- and cancer treatment-associated cognitive change: an update on the state of the science.
Authors: Ahles T.A. , Root J.C. , Ryan E.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2012-10-20 00:00:00.0; 30(30), p. 3675-86.
EPub date: 2012-10-20 00:00:00.0.
PMID: 23008308
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Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve.
Authors: Ahles T.A. , Saykin A.J. , McDonald B.C. , Li Y. , Furstenberg C.T. , Hanscom B.S. , Mulrooney T.J. , Schwartz G.N. , Kaufman P.A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2010-10-10 00:00:00.0; 28(29), p. 4434-40.
EPub date: 2010-10-10 00:00:00.0.
PMID: 20837957
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Cognitive function in breast cancer patients prior to adjuvant treatment.
Authors: Ahles T.A. , Saykin A.J. , McDonald B.C. , Furstenberg C.T. , Cole B.F. , Hanscom B.S. , Mulrooney T.J. , Schwartz G.N. , Kaufman P.A. .
Source: Breast Cancer Research And Treatment, 2008 Jul; 110(1), p. 143-52.
PMID: 17674194
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Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy.
Authors: Ferguson R.J. , McDonald B.C. , Saykin A.J. , Ahles T.A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-09-01 00:00:00.0; 25(25), p. 3866-70.
PMID: 17761972
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Cognitive-behavioral management of chemotherapy-related cognitive change.
Authors: Ferguson R.J. , Ahles T.A. , Saykin A.J. , McDonald B.C. , Furstenberg C.T. , Cole B.F. , Mott L.A. .
Source: Psycho-oncology, 2007 Aug; 16(8), p. 772-7.
PMID: 17152119
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Cognitive adverse effects of chemotherapy in breast cancer patients.
Authors: Correa D.D. , Ahles T.A. .
Source: Current Opinion In Supportive And Palliative Care, 2007 Apr; 1(1), p. 57-62.
PMID: 18660726
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Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy.
Authors: Ahles T.A. , Saykin A.J. , Furstenberg C.T. , Cole B. , Mott L.A. , Titus-Ernstoff L. , Skalla K. , Bakitas M. , Silberfarb P.M. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-07-01 00:00:00.0; 23(19), p. 4399-405.
PMID: 15994149
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The impact of adjuvant therapy for breast cancer on cognitive function: current evidence and directions for research.
Authors: Rugo H.S. , Ahles T. .
Source: Seminars In Oncology, 2003 Dec; 30(6), p. 749-62.
PMID: 14663776
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Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives.
Authors: Saykin A.J. , Ahles T.A. , McDonald B.C. .
Source: Seminars In Clinical Neuropsychiatry, 2003 Oct; 8(4), p. 201-16.
PMID: 14613048
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The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy.
Authors: Ahles T.A. , Saykin A.J. , Noll W.W. , Furstenberg C.T. , Guerin S. , Cole B. , Mott L.A. .
Source: Psycho-oncology, 2003 Sep; 12(6), p. 612-9.
PMID: 12923801
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Breast cancer chemotherapy-related cognitive dysfunction.
Authors: Ahles T.A. , Saykin A.J. .
Source: Clinical Breast Cancer, 2002 Dec; 3 Suppl 3, p. S84-90.
PMID: 12533268
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