Grant Details
Grant Number: |
7R01CA079039-03 Interpret this number |
Primary Investigator: |
Wenzel, Lari |
Organization: |
University Of California Irvine |
Project Title: |
Quality of Life of Gynecologic Cancer Survivors |
Fiscal Year: |
1999 |
Abstract
DESCRIPTION: (Applicant's Description)
The gynecologic malignancy survivor cohort is the largest population of
long-term female survivors of all cancer sites, with early-stage ovarian and
endometrial cases comprising the majority of these survivors. To date,
however, long-term quality of life (QOL) disruptions and survivorship
concerns within this cohort remain unknown, despite the prevalence of these
cancers, as well as the great potential for cure for those with early-stage
disease. We propose to enhance development of a gynecologic malignancy
survivorship model through evaluation of quality of life (QOL) concerns and
survivorship sequelae of women who are long-term early stage ovarian and
endometrial cancer survivors. In addition, we propose to examine potential
QOL differences for endometrial cancer clinical trial survivors. The study
population will include early stage ovarian or endometrial cancer survivors
who completed participation in Gynecology Oncology Group (GOG) clinical
trial #95 (ovarian) or GOG clinical trial #99 (endometrial) at least five
years ago and are without recurrent disease. To achieve our proposed study
goals, we will utilize the GOG database for subject identification and
recruitment. A one-hour telephone assessment will occur through the
established Computer Assisted Telephone Interviewing (CATI) Unit at AMC
Cancer Research Center. The specific aims of the study include the
following: 1) to describe the significant quality of life concerns and
long-term survivorship issues of women who were diagnosed and treated for
early-stage ovarian or endometrial cancer five or more years ago, 2) to
identify mechanisms which contribute to a gynecologic cancer survivorship
model through comparison and prediction of high versus low quality of life
associated with long-term adjustment and survivorship, and 3) to identify
and compare factors which predict high versus low quality of life for women
with early-stage endometrial cancer who completed participation in GOG
clinical trial #99. Results from this study could significantly contribute
to future survivorship interventions and influence the direction of care for
patients with these cancers.
Publications
Resilience, reflection, and residual stress in ovarian cancer survivorship: a gynecologic oncology group study.
Authors: Wenzel L.B.
, Donnelly J.P.
, Fowler J.M.
, Habbal R.
, Taylor T.H.
, Aziz N.
, Cella D.
.
Source: Psycho-oncology, 2002 Mar-Apr; 11(2), p. 142-53.
PMID: 11921330
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