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Grant Details

Grant Number: 5R21CA081639-02 Interpret this number
Primary Investigator: Kozlowski, Lynn
Organization: Pennsylvania State University-Univ Park
Project Title: Rdd Surveys and Molecular Genetics of Cigarette Smoking
Fiscal Year: 2000
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Abstract

Cigarette smoking is a major cause of cancer disability and deaths in the U.S. There is a significant need for developing methodologies to obtain representative, cost-effective samples of persons (especially siblings) for genetic studies on cigarette smoking. We propose to study the feasibility of using Random-digit dialing (RDD) computer-assisted telephone interview (CATI) surveys to create an adult sample of current smokers, former smokers, and never smokers who will also provide buccal cell DNA samples by mail. The innovativeness derives from using RDD telephone surveys to link self-reports of smoking behavior to DNA. Differential cooperation rates will be estimated for a study will be "made anonymous" with no follow-up versus a study that will be trying to establish a registry for confidential follow-up research with the same individual. Biases in non-response will be estimated by exploring what factors (e.g., sex, age, smoking status, education, geographic region) predict non-response at subsequent levels. Finally, genetic analyses will be performed to assess effects of candidate genes (CYP2A6 and CYP2D6) related to smoking phenotypes (smoking status, heaviness of smoking, and sensitivity to the first cigarette of the day). This is a multi-disciplinary proposal involving the techniques of social science as well as of molecular genetics.

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Publications

Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors.
Authors: Vandenbergh DJ, O'Connor RJ, Grant MD, Jefferson AL, Vogler GP, Strasser AA, Kozlowski LT
Source: Addict Biol, 2007 Mar;12(1), p. 106-16.
PMID: 17407504
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A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene.
Authors: Vandenbergh DJ, Grant MD, Severns V
Source: Mol Cell Probes, 2003 Dec;17(6), p. 319-20.
PMID: 14602484
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Using a telephone survey to acquire genetic and behavioral data related to cigarette smoking in "made-anonymous" and "registry" samples.
Authors: Kozlowski LT, Vogler GP, Vandenbergh DJ, Strasser AA, O'Connor RJ, Yost BA
Source: Am J Epidemiol, 2002 Jul 1;156(1), p. 68-77.
PMID: 12076890
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