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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA079654-06 Interpret this number
Primary Investigator: Bowen, Deborah
Organization: Fred Hutchinson Cancer Research Center
Project Title: Genetic Risk Information for a Defined Population
Fiscal Year: 2000
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Abstract

This project will evaluate different strategies for counseling female relatives of women with breast cancer. Potential subjects will be identified during a follow-up study of a population-based cohort of women diagnosed with breast cancer at age 45 or younger. Relatives of these probands will be offered the opportunity to participate in the counseling study. Based on an initial pedigree analysis, women from high-risk families (meeting criteria for autosomal dominant predisposition to breast cancer) will be offered genetic counseling and information regarding options for DNA testing to further evaluate inherited risk for breast cancer. We anticipate that we will identify 10-15 high-risk families in this study. Subjects not meeting the high-risk criteria will be randomized to one of four arms: (1) Genetic counseling: (2) Group education and counseling: (3) Counseling by their primary care provider, based on risk information provided by the study; and (4) A comparison group who will be provided only with informational materials about breast cancer risk and prevention. A total of 100 subjects will be enrolled in each arm. Counseling provided will include information on genetic and non-genetic risk factors for breast cancer, current recommendations for prevention and screening, and information on the potential role in the future of DNA-based testing for mutations associated with breast cancer risk. Subjects randomized to the primary care counseling and comparison groups will be offered the opportunity for genetic counseling after a 1- year follow-up period and data collection have been completed. Subjects will be surveyed before, immediately after and one year following counseling, to assess risk perception, degree of psychological distress related to breast cancer. breast cancer screening practices, understanding of genetic risks for breast cancer and interest in genetic testing, and interest in genetic testing. Follow-up of subjects from the high-risk families will include use of genetic testing and the psychological effects and preventive behaviors occurring after testing.

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Publications

Comparing sexual minority status across sampling methods and populations.
Authors: Bowen D.J. , Bradford J. , Powers D. .
Source: Women & health, 2006; 44(2), p. 121-34.
PMID: 17255062
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Retention in a breast cancer risk information trial: motivations of a population-based sample of women.
Authors: Ariail K. , Watts C.C. , Bowen D.J. .
Source: Health education & behavior : the official publication of the Society for Public Health Education, 2006 Oct; 33(5), p. 591-603.
EPub date: 2006-07-21.
PMID: 16861591
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The relationship between perceived risk, affect, and health behaviors.
Authors: Bowen D.J. , Alfano C.M. , McGregor B.A. , Andersen M.R. .
Source: Cancer detection and prevention, 2004; 28(6), p. 409-17.
PMID: 15582264
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Optimism, perceived risk of breast cancer, and cancer worry among a community-based sample of women.
Authors: McGregor B.A. , Bowen D.J. , Ankerst D.P. , Andersen M.R. , Yasui Y. , McTiernan A. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2004 Jul; 23(4), p. 339-44.
PMID: 15264969
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