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Grant Details

Grant Number: 5R01CA069334-04 Interpret this number
Primary Investigator: Mctiernan, Anne
Organization: Fred Hutchinson Cancer Research Center
Project Title: Exercise Effect on Sex Hormones in Postmenopausal Women
Fiscal Year: 2000
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Abstract

DESCRIPTION: (Adapted from Applicant's Abstract). The primary prevention of breast cancer is an important public health goal in this country. Exercise has been associated with a decreased risk for breast cancer. One mechanism may be via a hormonal pathway. Exercise decreases body fat, especially abdominal fat, which may be the mechanism through which exercise could lower concentrations of endogenous estrogens in premenopausal women. This application is a randomized interventional study that will test the effect of a one-year, moderate intensity exercise program on androgenous sex hormone profile in postmenopausal woman. Women (N=168) who are age 55-75 years will be randomized to either a one-year, moderate intensity exercise program or a controlled program of no change in exercise habits. Dietary intake will be assessed at baseline and follow-up through four-day food records. Serum hormones will be assayed at baseline and at end-of-study. These hormones include: total estrone, total estradiol, free estradiol, percent bioavailable estradiol, estrone sulfate, sex hormone binding globulin, albumin, testosterone, free testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, insulin, glucose and triglycerides. The ratio of urinary 2-hydroxyestrone (2-OHE1) to 16a-hydroxyestrone (16-alpha-E1), an estrogen metabolite ratio which may be associated with breast cancer, will also be assayed at baseline and at end-of-study. The effect of exercise on weight, body mass index, total fat mass, and body fat distribution will also be assessed. This study plans to give insight into possible mechanisms through which exercise may be associated with decreased risk of breast cancer.

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Publications

Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women.
Authors: Ulrich CM, Toriola AT, Koepl LM, Sandifer T, Poole EM, Duggan C, McTiernan A, Issa JP
Source: Epigenetics, 2012 Sep;7(9), p. 1020-8.
EPub date: 2012 Aug 7.
PMID: 22869041
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Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women.
Authors: Hooper LE, Foster-Schubert KE, Weigle DS, Sorensen B, Ulrich CM, McTiernan A
Source: Nutr Res, 2010 Mar;30(3), p. 163-70.
PMID: 20417876
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Higher habitual intake of dietary fat and carbohydrates are associated with lower leptin and higher ghrelin concentrations in overweight and obese postmenopausal women with elevated insulin levels.
Authors: Kong A, Neuhouser ML, Xiao L, Ulrich CM, McTiernan A, Foster-Schubert KE
Source: Nutr Res, 2009 Nov;29(11), p. 768-76.
PMID: 19932865
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Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women.
Authors: Meyers JA, Liu AY, McTiernan A, Wener MH, Wood B, Weigle DS, Sorensen B, Chen-Levy Z, Yasui Y, Boynton A, Potter JD, Ulrich CM
Source: J Endocrinol, 2008 Oct;199(1), p. 51-60.
EPub date: 2008 Jul 9.
PMID: 18614715
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Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women.
Authors: Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, Wood B, Selhub J, McTiernan A, Yasui Y, Oral E, Potter JD, Ulrich CM
Source: J Nutr, 2006 Jan;136(1), p. 189-94.
PMID: 16365081
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Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects.
Authors: Shade ED, Ulrich CM, Wener MH, Wood B, Yasui Y, Lacroix K, Potter JD, McTiernan A
Source: J Am Diet Assoc, 2004 Jun;104(6), p. 903-12.
PMID: 15175588
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Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women.
Authors: Atkinson C, Lampe JW, Tworoger SS, Ulrich CM, Bowen D, Irwin ML, Schwartz RS, Rajan BK, Yasui Y, Potter JD, McTiernan A
Source: Cancer Epidemiol Biomarkers Prev, 2004 May;13(5), p. 868-74.
PMID: 15159321
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