Grant Details
Grant Number: |
5U01CA074794-04 Interpret this number |
Primary Investigator: |
Potter, John |
Organization: |
Fred Hutchinson Cancer Research Center |
Project Title: |
Seattle Familial Colorectal Cancer Registry |
Fiscal Year: |
2000 |
Abstract
The Seattle Familial Colorectal Cancer Registry - proposed in response to
the Cooperative Family Registry for Epidemiologic Studies of Colon Cancer
(CFRCC) RFA (#CA96011) -- will be a population-based resource for studies
of colorectal cancer genetics. Cases will be identified by the Washington
SEER program, and will include men and women aged 20-74 years with a new
diagnosis of large bowel cancer. During a structured interview, first-
degree family members will be identified and subsequently interviewed.
For those families with a strong family history (proband plus two or more
affected first-degree relatives), second- and third-degree relatives will
also be interviewed. The interview will also elicit established and
environmental suspected risk factors. Blood from all cases, all members
of high-risk families, and a sample of other relative will be obtained, as
will tumor specimens for affected subjects. For comparison, population
controls will also be identified (through RDD and HCFA samples) and
interviewed, and a sample will provide blood specimens. As a member of
the CFRCCS, the Seattle Familial Registry will allow us to collect much
needed family data, including fifth generation and environmental factors,
and to address many important hypotheses through association, aggregation,
segregation, and linkage analyses.
Publications
None