Grant Details
Grant Number: |
3P01CA068384-03S1 Interpret this number |
Primary Investigator: |
Stellman, Steven |
Organization: |
Institute For Cancer Prevention |
Project Title: |
Interdisciplinary Studies in Cancer Epidemiology |
Fiscal Year: |
1999 |
Abstract
This Program Project is an integrated epidemiology and laboratory
investigation of current critical issues in the epidemiology of lung
cancer, the leading cause of cancer death in both men and women. It
represents a collaborative effort by scientists in several disciplines,
with the common theme of elucidating changes in lung cancer epidemiology,
histology, and cigarette composition that may have major public health
implications. In project 1 we propose a case-control study of lung cancer
to pursue new leads with respect to observed differences in risk
associated with both gender and race that may be related to differences in
environmental/lifestyle factors (such as estrogen replacement) and
metabolic factors (such as detoxification of carcinogens). Project 2 is a
biomarker study with smokers of cigarettes with varying yields, whose goal
it is to develop realistic estimates of actual biological dosage of
nicotine and carcinogens from cigarette smoke. Project 3 will utilize
metabolic and molecular techniques to investigate differences between
Blacks and Whites in activation of certain tobacco-derived nitrosamines
thought to be related to lung cancer, which is higher in Blacks, as well
as detoxification of aromatic amines involved in bladder cancer, which is
substantially lower in Blacks. Taken as a whole, this Program will
significantly contribute to our knowledge of the cause and prevention of
tobacco-related cancers, especially cancer of the lung.
Publications
None. See parent grant details.