Grant Details
| Grant Number: | 5R01CA027603-13 Interpret this number |
| Primary Investigator: | Hecht, Sidney |
| Organization: | University Of Virginia |
| Project Title: | Synthesis of Bleomycin Group Antibiotics |
| Fiscal Year: | 1991 |
Abstract
An abstract does not currently exist for this grant
Publications
RNA degradation by bleomycin, a naturally occurring bioconjugate.
Authors: Hecht SM
Source: Bioconjug Chem, 1994 Nov-Dec;5(6), p. 513-26.
PMID: 7533003
Related Citations
Grant Numbers:
| NCI NIH HHS - CA53913 | NCI NIH HHS - CA38544 | NCI NIH HHS - CA27603 |
MeSH Terms:
| Base Sequence | RNA, Transfer | RNA |
| Molecular Sequence Data | DNA | Crystallography, X-Ray |
| Nucleic Acid Conformation | Bleomycin |
A role for the metal binding domain in determining the DNA sequence selectivity of Fe-bleomycin.
Authors: Carter BJ, Murty VS, Reddy KS, Wang SN, Hecht SM
Source: J Biol Chem, 1990 Mar 15;265(8), p. 4193-6.
PMID: 1689722
Related Citations
Grant Numbers:
| NCI NIH HHS - CA38544 | NCI NIH HHS - CA27603 |
MeSH Terms:
| Molecular Structure | Metals | Base Sequence |
| Glycine | DNA Damage | DNA, Superhelical |
| Molecular Sequence Data | Molecular Conformation | Bleomycin |
| Binding Sites |
Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA.
Authors: Levy MJ, Hecht SM
Source: Biochemistry, 1988 Apr 19;27(8), p. 2647-50.
PMID: 2456777
Related Citations
Grant Numbers:
| NCI NIH HHS - CA38544 | NCI NIH HHS - CA27603 |
MeSH Terms:
| DNA, Viral | Nucleic Acid Denaturation | Bacteriophage phi X 174 |
| Copper | Plasmids | Bleomycin |
Copper-dependent cleavage of DNA by bleomycin.
Authors: Ehrenfeld GM, Shipley JB, Heimbrook DC, Sugiyama H, Long EC, van Boom JH, van der Marel GA, Oppenheimer NJ, Hecht SM
Source: Biochemistry, 1987 Feb 10;26(3), p. 931-42.
PMID: 2436656
Related Citations
Grant Numbers:
| NCI NIH HHS - CA38544 | NCI NIH HHS - CA27603 |
MeSH Terms:
| Kinetics | DNA | Copper |
| Dithiothreitol | Iron | Bleomycin |
| Structure-Activity Relationship |
DNA strand scission by bleomycin group antibiotics.
Authors: Sugiyama H, Ehrenfeld GM, Shipley JB, Kilkuskie RE, Chang LH, Hecht SM
Source: J Nat Prod, 1985 Nov-Dec;48(6), p. 869-77.
PMID: 2419510
Related Citations
Grant Numbers:
| NCI NIH HHS - CA38544 | NCI NIH HHS - CA27603 |
MeSH Terms:
| Oxygen | DNA, Viral | Base Sequence |
| Chemistry | Chemical Phenomena | Simian virus 40 |
| DNA | Chelating Agents | Bleomycin |
| Malondialdehyde |
Field desorption and fast atom bombardment mass spectrometry of bleomycins and their derivatives.
Authors: Dell A, Morris HR, Levin MD, Hecht SM
Source: Biochem Biophys Res Commun, 1981 Sep 30;102(2), p. 730-8.
PMID: 6171289
Related Citations
Grant Numbers:
| NCI NIH HHS - CA27603 |
MeSH Terms:
| Mass Spectrometry | Bleomycin | Structure-Activity Relationship |
| Protein Conformation |
