Grant Details
Grant Number: |
3P01CA017054-21S2 Interpret this number |
Primary Investigator: |
Ross, Ronald |
Organization: |
University Of Southern California |
Project Title: |
Cancer Epidemiology and Biostatistics Unit |
Fiscal Year: |
1998 |
Abstract
This proposal requests continued support for a Program Project Grant (PPG)
to conduct epidemiologic and biostatistical research on iatrogenic causes
of cancer by investigators at the Kenneth Norris Jr. (University of
Southern California) Comprehensive Cancer Center. This PPG is currently in
its 16th year of continuous funding.
The professional staff of this Program consists of 11 epidemiologists and
statisticians with major research interests in iatrogenic exposures and
cancer. The Scientific Program of the current application consists of 3
case-control studies. The successful conduct of these 3 projects depends
on 5 core resources. The 4 projects include the following: (1) A
continuation of an ongoing case-control study of the relationship of
hormone replacement therapy and breast cancer risk in postmenopausal women.
An expanded study will allow more detailed and precise evaluation of
duration and latency effects, the evaluation of interactions and adequate
adjustment for confounding factors; (2) A continuation of an ongoing case-
control study of analgesics and diuretics and renal cell carcinoma.
Preliminary results suggest that acetaminophen is associated with a greater
increment in risk than aspirin, but the strong correlation between
different formulations requires larger sample sizes to determine
independent effects; and A continuation of an ongoing case-control
study of diagnostic radiation and acute myelogenous leukemia.
Preliminary data suggest a dose response relationship between trunk x-rays
and risk but results are not statistically significant.
The major core resource for this PPG is the Cancer Surveillance Program, a
rapid ascertainment population-based tumor registry. Other core resources
include a Medical Record Retrieval Core for validating self-reported
prescription medications, diagnostic and therapeutic radiation, a Control
Identification Core for identifying neighborhood controls for case-control
studies, a Statistical Core for developing strategies for analyzing the
types of studies described above and an Administrative Core for overseeing
the scientific direction of the PPG and handling its fiscal administration.
Publications
None. See parent grant details.