Grant Details
Grant Number: |
3U01CA062912-04S1 Interpret this number |
Primary Investigator: |
Herbst, Arthur |
Organization: |
University Of Chicago |
Project Title: |
Des and Cancer of Vagina/Cervix--collaborative Studies |
Fiscal Year: |
1998 |
Abstract
The data which are collected and analyzed in the Registry provide the
sole comprehensive series of cases of DES-associated clear cell
adenocarcinoma (CCA) for comparative and collaborative study.
The specific aims are to update and enhance the data on currently
accessioned cases of CCA; to maximize ascertainment of newly diagnosed
cases; to add to the Registry women who have been treated but not
previously accessioned, by collaborating with the DES Cancer Network (DCN
- Collaborative Project A); to monitor the development of other
mullcrian-derived primary cancers, such as cancer of the fallopian tube
and endometrium to detect early any increase in occurrence; to serve as
a source of information for treating physicians and patients; and to
serve as a collaborating resource with NCI for other approved
investigators who will rely on the Registry participants and/or data for
research implementation.
Once an expanded cohort has been established by adding all identify new
cases of documented CCA, a questionnaire (approved by the Project
Steering Committee) will be applied to all study participants. This
questionnaire will incorporate new data for Registry as well as for the
collaborating investigations. Additional topics to be investigated
include extension of the age-incidence curve of CCA to older patients,
updating the survival curve and investigation of factors affecting
survival and recurrence including the complications of therapy. A
collaborative trial through NCI will be sought to develop an improved
regimen for recurrence therapy.
Two additional collaborative projects are proposed. The first is a case-
control study undertaken to assess risk factors for CCA among women
exposed to DES, in particular, to assess the relation of oral
contraceptive use, age at menarche, height, obesity, and season of
birth. In addition, epidemiologic factors that may promote
recurrence of CCA, in particular, the relation of height, obesity,
cigarette smoking, and estrogen replacement therapy will be
investigated, with emphasis on factors that may contribute to the
development of late (greater than 8 years) recurrences. The second study
will be to determine if human papillomavinus and p53 tumor suppressor
gene alterations, currently linked to the natural history of non-clear
cell carcinoma of the vagina and cervix, and associated with CCA.
Publications
None. See parent grant details.