Grant Details
Grant Number: |
5R01CA065422-02 Interpret this number |
Primary Investigator: |
Norman, Sandra |
Organization: |
University Of Pennsylvania |
Project Title: |
Breast Cancer Patterns of Care and Morbidity |
Fiscal Year: |
1998 |
Abstract
DESCRIPTION: Studies of treatment-associated morbidity are becoming
increasingly important as clinical trials continue to document equivalent
mortality rates for a variety of treatment options for breast cancer.
Lymphedema has been identified by women who experience it as one of the most
distressing long-term consequences of breast cancer treatment; yet there are
insufficient data about its incidence and risk factors to counsel women
appropriately. Sparse data suggest that risk may be higher in older women.
The Specific Aims of the proposed study are: 1) to measure prospectively
the incidence of lymphedema and identify risk factors for its occurrence,
using multivariate modelling to estimate the relative risk of lymphedema
associated with characteristics of the disease at diagnosis, and with
treatment, recurrence and patient-specific factors; and 2) to measure
health-related quality of life in breast cancer patients with and without
lymphedema, taking into account age, stage of disease, cancer treatment,
co-morbid conditions and other patient factors that can influence the
quality of life. A combined cross-sectional and prospective cohort design
will be used for this population-based study. A random sample of 900
patients newly diagnosed with primary breast cancer from Philadelphia and
Delaware Counties of Pennsylvania will be used to estimate the prevalence of
different treatment modalities for breast cancer and will be followed
prospectively to assess the incidence of lymphedema and risk factors for its
occurrence, as well as morbidity accompanying lymphedema, taking into
account type and extent of disease at diagnosis and other potentially
confounding factors. Data collection will include an in-person, hoe
interview, seven months after diagnosis to measure pre-existing
characteristics of patients that may be associated with late occurrences of
lymphedema, and to assess the presence of lymphedema and arm-related
morbidity; telephone follow-up interviews at 13, 19 and 25 months after
diagnosis to measure the occurrence of lymphedema and arm-related morbidity,
and exposures during the interval that may be associated with risk of
lymphedema; in-person observation of all patients whose questionnaire
results indicate the presence of lymphedema and a random sample of women,
who do not report lymphedema, and medical records review to obtain clinical
data regarding the characteristics of the disease at diagnosis, treatment
modality, and recurrence.
Publications
Risk factors for lymphedema after breast cancer treatment.
Authors: Norman S.A.
, Localio A.R.
, Kallan M.J.
, Weber A.L.
, Torpey H.A.
, Potashnik S.L.
, Miller L.T.
, Fox K.R.
, DeMichele A.
, Solin L.J.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 Nov; 19(11), p. 2734-46.
EPub date: 2010-10-26.
PMID: 20978176
Related Citations
Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptoms.
Authors: Norman S.A.
, Localio A.R.
, Potashnik S.L.
, Simoes Torpey H.A.
, Kallan M.J.
, Weber A.L.
, Miller L.T.
, Demichele A.
, Solin L.J.
.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-01-20; 27(3), p. 390-7.
EPub date: 2008-12-08.
PMID: 19064976
Related Citations