Grant Details
Grant Number: |
3R01CA047147-11S1 Interpret this number |
Primary Investigator: |
Newcomb, Polly |
Organization: |
University Of Wisconsin Madison |
Project Title: |
Physical Activity, Lifestyle and Ovarian Cancer Risk |
Fiscal Year: |
1998 |
Abstract
DESCRIPTION: (Adapted from Investigator's Abstract) The investigators
propose to continue their consortium of population-based case-control
studies to 1) investigate the relation between postmenopausal hormone
therapy and breast cancer mortality, and 2) evaluate the relation
between certain lifestyle factors, including weight change, physical
activity, pregnancy termination, and breast cancer incidence. (As in
the past, Wisconsin, Harvard, and Dartmouth will have submitted separate
applications with identical research plans.) Several studies have
suggested improved survival among women using estrogen preparations at
the time of breast cancer diagnosis. The investigators will evaluate the
relation between postmenopausal hormone therapy and breast cancer
mortality, ascertained though state vital records and the National Death
Index, among cases enrolled in our previous and ongoing collaborative
breast cancer studies in Wisconsin, Massachusetts, and New Hampshire
(1988-95). Of the nearly 13,000 cases enrolled, they estimate that a
minimum of 2600 deaths will have occurred in postmenopausal women. Thus,
they will have ample power to evaluate the effects of postmenopausal
hormone therapy, and to assess potential interactions with alcohol use
and obesity, which may influence endogenous hormone levels. In
addition, the availability of extensive questionnaire information will
allow exploration of the possible effects of other exposures, including
smoking and dietary factors, on breast cancer mortality. To meet their
second aim, they will enroll 9000 breast cancer cases aged 20-69 and a
comparable number of controls in our respective states over a 3-year
period. Cases will be identified through state tumor registries, and
controls through state drivers license lists and Medicare beneficiary
lists. The large sample size is necessary to evaluate study hypotheses
since the associations of interest are modest and patterns of exposure
infrequent, e.g., weight gain at specific ages and induced abortions
prior to full term pregnancies. The investigators state that the
proposed studies, based on an efficient, well-established mechanism for
selecting and interviewing cases and controls, and analysis of existing
population-based data on thousands of women with breast cancer, will
provide timely new information on potentially modifiable lifestyle
determinants of breast cancer incidence and survival, in a highly cost-
effective manner.
Publications
None. See parent grant details.