Grant Details
Grant Number: |
1R01CA074336-01A1 Interpret this number |
Primary Investigator: |
Thompson, Beti |
Organization: |
Fred Hutchinson Cancer Research Center |
Project Title: |
Cessation in Heavy Smokers Using Nrt and Adjuvant Video |
Fiscal Year: |
1998 |
Abstract
DESCRIPTION: Heavy smokers account for a disproportionately high share of
the morbidity and mortality connected with smoking and are more likely to
request assistance in dealing with their tobacco addiction, especially the
physiological aspects of cessation. Nicotine replacement therapy (NRT),
especially delivered through the transdermal patch, counteracts some of the
withdrawal effects of smoking cessation; however, NRT alone is not
sufficient to produce long-term success in smoking cessation. Standard
adjuvant materials that accompany the patch are booklets describing how a
person should quit. Given that the majority of heavy smokers are in low
socioeconomic strata or in blue-collar occupations, the written materials
may not be the most appropriate method of learning. Indeed, evidence
suggests that visual learning strategies are more likely to be used by this
group. Thus, the investigators propose to develop video tape, adjuvant to
NRT, to increase quit rates among heavy smokers. The specific aims of this
proposed project are to: 1) develop a video adjunct to nicotine replacement
therapy (NRT) that is built on input from heavy smokers; 2) test the
efficacy of NRT plus video versus NRT plus standard materials in achieving 6
month abstinence among heavy smokers in a randomized controlled trial; and
3) assess the cost-effectiveness of NRT plus video intervention versus NRT
plus standard materials.
This 42 month study will begin with a qualitative study to develop the
tailored video for the heavy smokers (smokers who smoke 25 or more
cigarettes per day) participating in the project. The initial basis for
development will be elicitation interviews with heavy smokers and former
heavy smokers (who quit within the past year). Content analysis of the
elicitation interviews will identify the major issues, concerns, barriers,
and facilitators for quitting among this group, as well as potential
messages that may be useful in convincing others to quit. Results from the
elicitation interviews will be explored in a series of focus groups where
standard focus group questioning will be conducted and trigger films and
video rough-cuts will be discussed. Following the development of the
intervention video and other materials, a randomized, controlled trial will
be conducted in which one arm of the study receives NRT with the video
intervention and the other arm receives NRT with standard, available
materials. The primary outcome is self-reported six month continuous
smoking cessation, verified by expired CO at 6 months post-cessation. A
second primary outcome is the cost-effectiveness of the intervention.
Secondary outcomes include end of treatment cessation, number of quit
attempts, use of NRT, and use of the video intervention. With an
anticipated difference of 10 percentage points between the two arms, a .05
level of significance, and 80 percent power, approximately 200 heavy smokers
will need to be recruited to each arm of the study.
Publications
Heavy smokers: a qualitative analysis of attitudes and beliefs concerning cessation and continued smoking.
Authors: Thompson B.
, Thompson L.A.
, Thompson J.
, Fredickson C.
, Bishop S.
.
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003 Dec; 5(6), p. 923-33.
PMID: 14668076
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