Grant Details
Grant Number: |
1R01CA071777-01 Interpret this number |
Primary Investigator: |
Li, De-Kun |
Organization: |
Kaiser Foundation Research Institute |
Project Title: |
Induced Abortion and Breast Cancer Risk |
Fiscal Year: |
1998 |
Abstract
(Adapted from the Applicant's Abstract): Induced abortion has been
associated with an increased risk of breast cancer, but only a small
number of well-conducted studies have reported on the relationship. A
key challenge to the findings reported in those studies concerns the
possible inaccuracy of self-reported information on induced abortion:
Breast cancer cases may have been more willing than women without a
life-threatening illness to report their history of abortion, resulting
in spurious, positive findings. We propose a population-based case-
control study to examine the relationship. To increase the accuracy of
information on induced abortion, the study will be conducted in
Shanghai, China, where induced abortion is not stigmatized and where
family planning records document reproductive history. All women aged
54 years and younger, newly diagnosed with breast cancer during 1997
through mid-1999 and resident in Shanghai, will be identified through
the population-based Shanghai Cancer Registry. The same number of age-
matched controls will be randomly selected from the population of the
geographic area. Approximately 1,470 cases and 1,470 controls will be
interviewed to ascertain the number, timing, and outcome of all
pregnancies; other reproductive, menstrual, and contraceptive
characteristics; family history of breast cancer; and other risk factors
for breast cancer. In addition, we will abstract the reproductive
records dept for each participant by the Family Planning Committee.
They contain a detailed history of each pregnancy and will be used to
enhance the accuracy of the information on induced abortion. Medical
records will be requested to obtain information on a history of benign
breast disease and use of breast-cancer screening services. The
association of induced and spontaneous abortion with breast cancer risk
will be examined in relation to age at abortion, parity, and timing of
the abortion (before and after first full-term pregnancy, interval to
next full-term pregnancy, gestational age.) Should a relationship with
induced abortion be found, it will be possible to provide women who are
contemplating abortion better information on the possible risks of the
procedure in relation to age, parity, and timing of the procedure.
Publications
Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China.
Authors: Shen Y.
, Li D.K.
, Wu J.
, Zhang Z.
, Gao E.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006 Feb; 15(2), p. 342-7.
PMID: 16492926
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