Grant Details
Grant Number: |
3P01CA250989-03S1 Interpret this number |
Primary Investigator: |
Brewer, Noel |
Organization: |
Univ Of North Carolina Chapel Hill |
Project Title: |
Program Project – Improving Provider Announcement Communication Training (IMPACT) |
Fiscal Year: |
2023 |
Abstract
PROJECT SUMMARY/ABSTRACT
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-
23-044. Human papillomavirus (HPV) infections cause nearly 35,000 cervical, anal, oropharyngeal, and other
cancers a year in the United States. Up-to-date (UTD) HPV vaccination (i.e. 2 doses by age 13) is only 49% as
of 2021, far behind the >85% coverage of tetanus-diphtheria-acellular pertussis and meningococcal conjugate
vaccines also recommended at this age. A provider’s clear recommendation for HPV vaccination has a
large effect on uptake, and recommending HPV vaccination at ages 9-10 is associated with higher rates
of UTD HPV vaccination. To support more effective monitoring by state vaccination programs, the Centers for
Disease Control and Prevention (CDC) is supporting expanded use of immunization information systems (IIS).
Jurisdictions can integrate clinical decision support into IIS based on state and local priorities,
forecasting when recommended vaccines are due and disseminating these recommendations
consistently statewide. Data are needed on a) how IIS are configured and which factors influence state-
specific IIS design and functionality; b) whether state IIS trigger age-based HPV vaccination alerts to guide
provider recommendations; and c) how the age of HPV vaccination alerts is decided. Characterizing state IIS
features will provide preliminary data for future studies to evaluate their impacts on provider
recommendations for HPV vaccination and rates of UTD HPV vaccination. This proposed supplement to
the “Improving Provider Announcement Communication Training” project (1P01CA250989-01A1, PI: Brewer)
will evaluate the impact of state IIS policies and priorities on HPV vaccination rates with three activities:
1) Gather and document data from the published literature, immunization program webpages for the 64 US
states and jurisdictions receiving funding, and immunization program personnel; 2) Identify up to 15 IIS policy
stakeholders in three states with contrasting HPV vaccination forecasting; and 3) Disseminate case summaries
to guide IIS priority-setting and implementation across jurisdictions. This supplement will advance the goals
of the parent P01 Program Project by optimizing important precursors to clinical staff's HPV
vaccination recommendation: rapid and convenient ascertainment of a patient's HPV vaccination status, and
ability to identify vaccine-eligible patients at the earliest opportunity. The project activities will provide data
to support future empirical analyses of associations between state IIS policies and optimal cancer
prevention, with potential to harmonize national HPV vaccination recommendations and update
national HPV vaccination policies.
Publications
None. See parent grant details.