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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 2R01CA094069-11A1 Interpret this number
Primary Investigator: Whittemore, Alice
Organization: Stanford University
Project Title: Statistical Methods for Genetic Epidemiology
Fiscal Year: 2013
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DESCRIPTION (provided by applicant): Cost-effective cancer prevention and control strategies that emphasize population subgroups at highest risk are increasingly needed to counter national and global health costs. The proposed research will address this need by helping identify high-risk individuals in three specific aims. The first aim is to develop more informative measures of model performance that can focus on specific population subgroups. In particular, we will develop and evaluate better measures of model accuracy (calibration), and model discrimination between those likely and unlikely to develop the adverse outcome. The second aim is to develop new ways to expand the utility of epidemiologic data for assessing model performance. These methods will allow investigators to accommodate cohort selection bias in assessing model performance; use and interpret case-control data for assessing model discrimination; and assess risks of multiple competing adverse outcomes in the same individual. The third aim is to augment the freely available R-based software RMAP (Risk Model Assessment Program) to include the new and more informative performance measures and allow investigators to apply them to a broad range of epidemiologic data.

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Performance Of Prediction Models For Brca Mutation Carriage In Three Racial/ethnic Groups: Findings From The Northern California Breast Cancer Family Registry
Authors: Kurian A.W. , Gong G.D. , John E.M. , Miron A. , Felberg A. , Phipps A.I. , West D.W. , Whittemore A.S. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Apr; 18(4), p. 1084-91.
PMID: 19336551
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Significance Levels For Studies With Correlated Test Statistics
Authors: Shi J. , Levinson D.F. , Whittemore A.S. .
Source: Biostatistics (oxford, England), 2008 Jul; 9(3), p. 458-66.
PMID: 18089626
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Prevalence Of Pathogenic Brca1 Mutation Carriers In 5 Us Racial/ethnic Groups
Authors: John E.M. , Miron A. , Gong G. , Phipps A.I. , Felberg A. , Li F.P. , West D.W. , Whittemore A.S. .
Source: Jama, 2007-12-26 00:00:00.0; 298(24), p. 2869-76.
PMID: 18159056
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Comparison Of Admixture And Association Mapping In Admixed Families
Authors: Clarke G. , Whittemore A.S. .
Source: Genetic Epidemiology, 2007 Nov; 31(7), p. 763-75.
PMID: 17508341
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Assessing Environmental Modifiers Of Disease Risk Associated With Rare Mutations
Authors: Whittemore A.S. .
Source: Human Heredity, 2007; 63(2), p. 134-43.
PMID: 17283442
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Sex Steroid Hormones In Young Manhood And The Risk Of Subsequent Prostate Cancer: A Longitudinal Study In African-americans And Caucasians (united States)
Authors: Tsai C.J. , Cohn B.A. , Cirillo P.M. , Feldman D. , Stanczyk F.Z. , Whittemore A.S. .
Source: Cancer Causes & Control : Ccc, 2006 Dec; 17(10), p. 1237-44.
PMID: 17111254
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Getting More From Digital Snp Data
Authors: El Karoui N. , Zhou W. , Whittemore A.S. .
Source: Statistics In Medicine, 2006-09-30 00:00:00.0; 25(18), p. 3124-33.
PMID: 16397858
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Nonparametric Linkage Analysis Using Person-specific Covariates
Authors: Whittemore A.S. , Halpern J. .
Source: Genetic Epidemiology, 2006 Jul; 30(5), p. 369-79.
PMID: 16671107
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Prostate Specific Antigen Levels In Young Adulthood Predict Prostate Cancer Risk: Results From A Cohort Of Black And White Americans
Authors: Whittemore A.S. , Cirillo P.M. , Feldman D. , Cohn B.A. .
Source: The Journal Of Urology, 2005 Sep; 174(3), p. 872-6; discussion 876.
PMID: 16093978
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Covariate Adjustment In Family-based Association Studies
Authors: Whittemore A.S. , Halpern J. , Ahsan H. .
Source: Genetic Epidemiology, 2005 Apr; 28(3), p. 244-55.
PMID: 15593089
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Prevalence Of Brca1 Mutation Carriers Among U.s. Non-hispanic Whites
Authors: Whittemore A.S. , Gong G. , John E.M. , McGuire V. , Li F.P. , Ostrow K.L. , Dicioccio R. , Felberg A. , West D.W. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2004 Dec; 13(12), p. 2078-83.
PMID: 15598764
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Classifying Disease Chromosomes Arising From Multiple Founders, With Application To Fine-scale Haplotype Mapping
Authors: Yu K. , Martin R.B. , Whittemore A.S. .
Source: Genetic Epidemiology, 2004 Nov; 27(3), p. 173-81.
PMID: 15389930
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Genetic Association Tests For Family Data With Missing Parental Genotypes: A Comparison
Authors: Whittemore A.S. , Halpern J. .
Source: Genetic Epidemiology, 2003 Jul; 25(1), p. 80-91.
PMID: 12813729
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Optimal Designs For Estimating Penetrance Of Rare Mutations Of A Disease-susceptibility Gene
Authors: Gong G. , Whittemore A.S. .
Source: Genetic Epidemiology, 2003 Apr; 24(3), p. 173-80.
PMID: 12652521
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