The Shanghai Endometrial Cancer Study (R01 CA92585) is thus far the largest population-based study of
endometrial cancer, involving 1204 cases and 1212 controls. Over the past 6 years we have produced many
significant, novel research findings from this study, particularly those related to soy food intake, tea
consumption, genetic polymorphisms in the estrogen pathway, and gene-diet interactions in relation to the risk
of endometrial cancer. In this renewal application, we propose to evaluate a new set of hypotheses related to
the role of genetic variations in inflammation pathway genes in the developm ent of endometrial cancer. These
genes were chosen because of the recently recognized critical role that inflammation and because of laboratory
evidence indicating their interaction with estrogens and diet in the developm ent and progression of endometrial
cancer. To reduce type I errors and enhance the statistical power of the study for gene-disease association
studies, as well as gene-gene and gene-diet interactions, w e propose to recruit an additional 400 cases and
400 controls as part of this renewal proposal which will be used to validate all promising associations identified
in the funding cycle and during the initial funding cycle. The proposed study, with its strong methodology and
novel hypotheses, has great potential for discovering genetic markers and gene-d iet interactions that will be
valuable for the prevention of endometrial cancer, one of the most common gynecological malignancies in the
United States and many other parts of the world.
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