DESCRIPTION (Adapted from the Applicant's Abstract): This project proposes to
study the long-term health and lifestyle outcomes for study participants of a
population-based case/control study of female breast carcinoma in-situ (BCIS).
The study population includes all cases of female BCIS diagnosed among
residents of the state of Connecticut from September 15, 1994 to March 14, 1998
as well as a series of random-digit-dial controls also selected from the state
of Connecticut. Cases will be between the ages of 20 and 84 years at time of
diagnosis while controls are frequency matched to the cases by five-year
intervals. Current response rates indicate that the final sample will include
approximately 1200 cases and 1200 controls. Baseline telephone interviews have
already been conducted with the study subjects and include information on
family history of cancer, pregnancy and menstrual history, hormone replacement
therapy, oral contraceptive use, as well as socio-demographic variables. In
addition, paraffin-embedded tumor tissue is being collected for each case to
test for the presence of estrogen (ER), progesterone (PR), p53, and HER-2/neu
The current application proposes to recontact study participants at five years
from time of initial diagnosis/initial contact. Study subjects will again be
asked to participate in a telephone interview to collect updated information on
selected topic areas covered in the initial questionnaire such as medical
history (breast recurrences, second cancers), family history, pregnancy and
menstrual history but also to collect new information on selected measures of
well-being and functioning including depression, career, sexual relations, and
insurance. In addition, we will ask women to provide us with buccal specimens
for BRCA1/BRCA2 testing. The goals of the study are as follows: 1) To provide
annual and five-year cumulative estimates of ipsilateral and contralateral
breast cancer risk, regional or distant metastatic disease risk, second cancer
risk as well as death for women diagnosed with BCIS. 2) To assess the
psychosocial impact of BCIS by examining differences between cases and controls
on selected measures of well-being and functioning at five years after original
recruitment. 3) To measure the association between clinical variables such as
hormone receptor positivity and comedo necrosis on outcome for case subjects.
4) To assess the association between epidemiologic risk factors such as age and
a family history of breast cancer with outcome, 5) To provide population-based
estimates of BRCA1 and BRCA2 in BCIS. 6) To validate/evaluate current
histopathologic classification schemes for BCIS with respect to clinical
outcome. This project represents one of the first large attempts to assess the
survivorship experience of women with BCIS. The data are unique in that
epidemiologic, biologic and clinical variables will have been collected
allowing us to study the relationship of these variables with long term
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