||5R01CA074877-04 Interpret this number
||Cancer Prevention Instit Of California
||Phytoestrogens, Physical Activity and Endometrial Cancer
DESCRIPTION: This population-based epidemiologic study will examine the
role that nutritionally-related factors play in the development of
endometrial cancer. Special emphasis will be placed on phytoestrogens
(i.e., weak estrogens, derived from plant foods, that may have
antiestrogenic effects) and physical activity. Little is known about how
these factors affect endometrial cancer risk and both offer potential
avenues for prevention. Additionally, there are plans to determine whether
the effects of obesity, a strong risk factor for endometrial cancer, can be
modified by high levels of phytoestrogen consumption. Building on research
currently being conducted, there are plans to examine the effects of seven
specific phytoestrogenic compounds. The proposed case-control study will be
conducted in the San Francisco Bay Area, an ethnically and culturally
heterogeneous population, providing substantial variation in dietary intake,
including phytoestrogen consumption, and physical activity. White, African
American and Latina women, aged 35-79, diagnosed with endometrial cancer
during a three-year period, will be identified. These cases will be
frequency-matched to controls, based on ethnicity and five-year age group.
Controls will be identified from control women, participating in an ongoing,
population-based, case-control study of breast cancer, which addresses
analogous hypotheses. The questionnaire being used in that study, which was
developed specifically to address these areas (including a comprehensive
assessment of diet and lifetime occupational and leisure time physical
activity), will be used in the proposed study. In-person interviews will be
conducted in English or Spanish and anthropometric measurements taken.
After initial examination of the data, analyses will be conducted, using
unconditional logistic regression, adjusting for age, ethnicity and
potential confounders. By combining this research with the ongoing breast
cancer study, the proposed study will provide important information on
endometrial cancer aetiology and the relationship between breast and
endometrial cancer aetiology in terms of these modifiable,
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