DESCRIPTION: (Applicant's Description) In recent years, numerous studies
have suggested that the consumption of soybeans and soybean-containing foods
may contribute to the lower rates of breast, colon, and prostate cancer in
Asia as compared to the U.S. and other Westernized countries.
Unfortunately, there is currently no available or tested dietary assessment
instrument for the measurement of soyfood consumption and/or isoflavone
intake, especially in populations consuming a Western diet.
The objective of this proposed study is to develop and validate a soyfood
questionnaire that is appropriate for use in epidemiologic studies of diet
and health. The specific aims of this proposal are: 1) To conduct a
systematic survey of soyfoods available in a large, metropolitan area in the
U.S., and use that information to develop a soyfood questionnaire; 2) To
validate the soy questionnaire against plasma isoflavone (genistein and
daidzein) concentrations; 3) To examine the association between plasma
isoflavone concentrations and soy intake as measured by the soyfood
questionnaire compared to the Women's Health Initiative Food Frequency
Questionnaire (FFQ), which contains only two questions on soyfoods (soy milk
We propose to develop a soyfood questionnaire and test its validity.
Specifically, we will assess the bias and precision of genistein and
daidzein intake estimated from a soyfood questionnaire with the plasma
levels of these compounds. This study takes advantage of already collected
data and requests resources needed to: 1) collect data on additional
individuals; 2) conduct a more systematic study of soyfood availability; 3)
document our nutrient database; and 4) measure plasma genistein and daidzein
concentrations. A total sample of 63 men and 63 women will complete soyfood
questionnaires, a FFQ, and provide fasting blood samples.
This work fills an important methodologic gap in epidemiologic research by
providing investigators with a validated instrument for monitoring soyfood
and isoflavone exposure in population-based studies in the United States.
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