||5R01CA063706-05 Interpret this number
||University Of California Irvine
||Gene/Environment Study of Familial Colorectal Cancer
We propose to conduct a genetic-epidemiologic study of familial colorectal
cancer. Probands with colorectal cancer will be ascertained from
population-based cancer registries in Imperial, Orange, and San Diego
counties in Southern California. Based on family history information
available in the registry, we will identify and recruit approximately 130
families that report a history of at least three cases of colorectal
cancer in two generations. More detailed pedigree information will be
obtained via a telephone interview. From these families, we will identify
80 multiple-case families that are judged to be potentially the most
informative for linkage analyses, based on a simulated lod score criterion
(using SIMLINK). Each member of these linkage-informative families will
be asked to provide one sample of blood for DNA analyses and to complete
questionnaires on risk factors for colorectal cancer. Efforts will be
made to verify all reported cancers and all causes of death. For cases
with colorectal cancer or any other cancer, we will obtain pathology
reports and tumor blocks. Our objectives are to 1) identify the familial
colon cancer (FCC) gene on chromosome 2; 2) study the effects of other
putative risk factors for colon cancer, including diet, physical activity,
nonsteroidal anti-inflammatory drugs, and hormones; 3) study gene-
environment interactions, with a focus on factors that affect the
expression or penetrance of the FCC gene; and 4) define sources of
heterogeneity (i.e., what variables discriminate between families that do
or do not involve the FCC gene). The primary analytical technique is
linkage analysis that incorporates information on environmental
covariates. In linked families, informative recombinants for fine mapping
of the FCC locus will be identified. In unlinked families we will look
for alternative pathways. This proposed study is Project 1. Project 2
focuses on gene-environment interactions in colorectal polyps. Project 3
focuses on the molecular genetics of colorectal polyps and cancer. The
molecular work for this study will be conducted as a part of Project 3.
Differential Effects Of Wine Consumption On Colorectal Cancer Outcomes Based On Family History Of The Disease
, McEligot A.J.
, Ziogas A.
, Holcombe R.F.
, Anton-Culver H.
Nutrition And Cancer, 2007; 59(1), p. 36-45.
Cancer Prevention Strategies: Use Of Cancer Prevention Research Registries
Environmental Health Perspectives, 1995 Nov; 103 Suppl 8, p. 237-9.