Grant Number:	5U01CA265729-05 Interpret this number
Primary Investigator:	Hur, Chin
Organization:	Columbia University Health Sciences
Project Title:	Comparative Modeling of Gastric Cancer Health Drivers and Prevention in the Us and Globally
Fiscal Year:	2025

Gastric cancer (GC), specifically gastric adenocarcinoma, is the fifth most common cancer and remains a major cause of cancer-related mortality in the United States. Risk of GC varies across groups, reflecting differences in underlying exposures such as Helicobacter pylori (H. pylori) infection, smoking, and access to preventive care. Several developments are reshaping the landscape of GC prevention, including a better understanding of disease natural history, new findings from prospective studies, and anticipated results from ongoing randomized trials. Because early GC detection can dramatically improve survival by enabling curative surgical or noninvasive endoscopic resection, new prevention and detection strategies have the potential to significantly improve population health. While H. pylori eradication has been a primary focus of prevention, variation in infection prevalence and outcomes underscores the importance of optimizing screen-and-treat interventions for groups at elevated risk. Another promising approach is targeted endoscopic screening for individuals with precursor lesions such as gastric intestinal metaplasia, who benefit from surveillance in many clinical settings. Identifying effective and cost-effective strategies to address these challenges in the United States remains a critical need. This work builds upon prior modeling and clinical studies of GC and H. pylori, secondary database analyses, and prevention research. The research team brings together expertise in simulation and comparative modeling, deep clinical knowledge across the spectrum of GC prevention and care, and a track record of informing cancer control policy. The overarching goal is to generate innovative, evidence-based tools to guide prevention and early detection strategies, improve efficiency of health care resources, and ultimately reduce the burden of gastric cancer in the U.S.




Recent US Gastric Cancer Prevention Recommendations: Advances, Unanswered Questions, and the Need for a Unified Approach.
Authors: Mülder D.T. , O'mahony J.F. , Laszkowska M. , Yeh J. , Hur C. , Lansdorp-Vogelaar I. , CISNET-Gastric Group .
Source: Gastroenterology, 2025 Sep; 169(4), p. 545-550.
EPub date: 2025-04-30 00:00:00.0.
PMID: 40315963
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The Optimal Age of Helicobacter pylori Screen-and-Treat for Gastric Cancer Prevention in the United States.
Authors: Mülder D.T. , O'Mahony J.F. , Sun D. , van Duuren L.A. , van den Puttelaar R. , Harlass M. , Han W. , Huang R.J. , Spaander M.C.W. , Ladabaum U. , et al. .
Source: Helicobacter, 2025 May-Jun; 30(3), p. e70039.
PMID: 40329483
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Treatment outcomes of non-curative endoscopic submucosal dissection for superficial gastric neoplasia: A retrospective study at a tertiary care center in the United States.
Authors: Nagao S. , Nishimura M. , Koseki M. , Beauvais J. , Laszkowska M. , Tang L. , Strong V.E. , Schattner M.A. .
Source: Den Open, 2025 Apr; 5(1), p. e70034.
EPub date: 2024-11-08 00:00:00.0.
PMID: 39524150
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Utility Values of Health Status in Gastric Cancer: A Systematic Review.
Authors: Gonzalez C. , Espinoza M. , Libuy M. , Crispi F. , Riquelme A. , Alarid-Escudero F. , Latorre G. , Pizarro M. , Cuadrado C. .
Source: Value In Health Regional Issues, 2025 Mar; 46, p. 101063.
EPub date: 2025-02-01 00:00:00.0.
PMID: 39892180
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Impact of population screening for Lynch syndrome insights from the All of Us data.
Authors: Park J. , Karnati H. , Rustgi S.D. , Hur C. , Kong X.F. , Kastrinos F. .
Source: Nature Communications, 2025-01-09 00:00:00.0; 16(1), p. 523.
EPub date: 2025-01-09 00:00:00.0.
PMID: 39788943
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Cost-Effectiveness of Serum Pepsinogen as a Gastric Cancer Targeted Screening Strategy in the United States.
Authors: Oh A. , Rustgi S.D. , Hur C. , In H. .
Source: Gastro Hep Advances, 2025; 4(2), p. 100564.
EPub date: 2024-10-10 00:00:00.0.
PMID: 39866720
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Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young- and Average-Onset Gastric Cancer.
Authors: Magahis P.T. , Cornet N. , Tang L. , Arora K. , Hingorani N. , King S. , Markowitz A.J. , Schattner M. , Shimada S. , Maron S.B. , et al. .
Source: Cancer Medicine, 2024 Dec; 13(23), p. e70451.
PMID: 39629931
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Global Progression Rates of Precursor Lesions for Gastric Cancer: A Systematic Review and Meta-Analysis.
Authors: Hahn A.I. , Mülder D.T. , Huang R.J. , Zhou M.J. , Blake B. , Omofuma O. , Murphy J.D. , Gutiérrez-Torres D.S. , Zauber A.G. , O'Mahony J.F. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2024-10-01 00:00:00.0; , .
EPub date: 2024-10-01 00:00:00.0.
PMID: 39362617
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CLINICOPATHOLOGICAL CHARACTERISTICS AND RISK FACTORS OF YOUNG-ONSET GASTRIC CARCINOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Authors: Li Y. , Hahn A.I. , Laszkowska M. , Jiang F. , Zauber A.G. , Leung W.K. .
Source: Clinical And Translational Gastroenterology, 2024-05-08 00:00:00.0; , .
EPub date: 2024-05-08 00:00:00.0.
PMID: 38717039
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Global burden of young-onset gastric cancer: a systematic trend analysis of the global burden of disease study 2019.
Authors: Li Y. , Hahn A.I. , Laszkowska M. , Jiang F. , Zauber A.G. , Leung W.K. .
Source: Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association, 2024-04-03 00:00:00.0; , .
EPub date: 2024-04-03 00:00:00.0.
PMID: 38570392
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Prevalence of Gastric Precursor Lesions in Countries with Differential Gastric Cancer Burden: A Systematic Review & Meta-Analysis.
Authors: Mülder D.T. , Hahn A.I. , Huang R.J. , Zhou M.J. , Blake B. , Omofuma O. , Murphy J.D. , Gutiérrez-Torres D.S. , Zauber A.G. , O'Mahony J.F. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2024-03-02 00:00:00.0; , .
EPub date: 2024-03-02 00:00:00.0.
PMID: 38438000
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The Effect of Nationwide Organized Cancer Screening Programs on Gastric Cancer Mortality: A Synthetic Control Study.
Authors: Sun D. , Mülder D.T. , Li Y. , Nieboer D. , Park J.Y. , Suh M. , Hamashima C. , Han W. , O'Mahony J.F. , Lansdorp-Vogelaar I. .
Source: Gastroenterology, 2024 Mar; 166(3), p. 503-514.
EPub date: 2023-11-24 00:00:00.0.
PMID: 38007053
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Endoscopic Surveillance of Intestinal Metaplasia of the Esophagogastric Junction: A Decision Modeling Analysis.
Authors: Yoon J.Y. , Lim F. , Shah S.C. , Rubenstein J.H. , Abrams J.A. , Katzka D. , Inadomi J. , Kim M.K. , Hur C. .
Source: The American Journal Of Gastroenterology, 2024-01-26 00:00:00.0; , .
EPub date: 2024-01-26 00:00:00.0.
PMID: 38275234
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Epidemiology of Gastric Malignancies 2000-2018 According to Histology: A Population-Based Analysis of Incidence and Temporal Trends.
Authors: Rustgi S.D. , McKinley M. , McBay B. , Zylberberg H.M. , Gomez S.L. , Hur C. , Kastrinos F. , Gupta S. , Kim M.K. , Itzkowitz S.H. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023 Dec; 21(13), p. 3285-3295.e8.
EPub date: 2023-02-14 00:00:00.0.
PMID: 36792000
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Epidemiology of Gastric Malignancies 2000-2018 According to Histology: A Population-Based Analysis of Incidence and Temporal Trends.
Authors: Rustgi S.D. , McKinley M. , McBay B. , Zylberberg H.M. , Gomez S.L. , Hur C. , Kastrinos F. , Gupta S. , Kim M.K. , Itzkowitz S.H. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023 Dec; 21(13), p. 3285-3295.e8.
EPub date: 2023-02-14 00:00:00.0.
PMID: 36792000
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Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors.
Authors: Magahis P.T. , Maron S.B. , Cowzer D. , King S. , Schattner M. , Janjigian Y. , Faleck D. , Laszkowska M. .
Source: Journal For Immunotherapy Of Cancer, 2023 Oct; 11(10), .
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Factors associated with detection of hereditary diffuse gastric cancer on endoscopy in individuals with germline CDH1 mutations.
Authors: Laszkowska M. , Tang L. , Vos E. , King S. , Salo-Mullen E. , Magahis P.T. , Abate M. , Catchings A. , Zauber A.G. , Hahn A.I. , et al. .
Source: Gastrointestinal Endoscopy, 2023 Sep; 98(3), p. 326-336.e3.
EPub date: 2023-04-23 00:00:00.0.
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Management of Gastric Intestinal Metaplasia.
Authors: Rustgi S.D. , Zylberberg H.M. , Hur C. , Shah S.C. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023-04-19 00:00:00.0; , .
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Controlling Gastric Cancer in a World of Heterogeneous Risk.
Authors: Huang R.J. , Laszkowska M. , In H. , Hwang J.H. , Epplein M. .
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Cost-effectiveness of screening with polymerase chain reaction for Helicobacter pylori to prevent gastric cancer and peptic ulcers.
Authors: Oh A. , Truong H. , Kim J. , Rustgi S.D. , Abrams J.A. , Hur C. .
Source: Journal Of Gastrointestinal Oncology, 2022 Oct; 13(5), p. 2186-2196.
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A Tutorial on Time-Dependent Cohort State-Transition Models in R Using a Cost-Effectiveness Analysis Example.
Authors: Alarid-Escudero F. , Krijkamp E. , Enns E.A. , Yang A. , Hunink M.G.M. , Pechlivanoglou P. , Jalal H. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2022-09-16 00:00:00.0; , p. 272989X221121747.
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Heightened Risk for Gastric Cancer Among Immigrant Populations in New York State from High-Incidence Countries.
Authors: Laszkowska M. , Zhang X. , Kuliszewski M.G. , Hur C. , Gastric Cancer Epidemiology Group .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2022-08-18 00:00:00.0; , .
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Databases for Gastrointestinal Clinical and Public Health Research: Have Database, Will Research.
Authors: Rustgi S.D. , Zylberberg H.M. , Hur C. .
Source: Gastroenterology, 2022 Jul; 163(1), p. 31-34.
EPub date: 2022-04-27 00:00:00.0.
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Testing and Treating Helicobacter pylori Infection in Individuals With Family History of Gastric Cancer is Cost-effective.
Authors: Rustgi S.D. , Oh A. , Hur C. .
Source: Gastroenterology, 2021 12; 161(6), p. 2051-2052.e4.
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