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Grant Details

Grant Number: 1R01CA288824-01A1 Interpret this number
Primary Investigator: Elmore, Joann
Organization: University Of California Los Angeles
Project Title: Optimizing the Human-Computer Interaction in Pathology: Understanding the Impact of Computer-Aided Diagnosis Tools on Pathologists' Interpretive Performance
Fiscal Year: 2025


Abstract

SUMMARY Accurate pathologic diagnoses, such as a cancer diagnosis, are the cornerstone of quality patient care. Accurate diagnoses require pathologists to perform a complex series of perceptual and cognitive tasks including visual search, pattern recognition, and decision-making. New artificial intelligence (AI) and computer- aided diagnosis (CAD) technology shows promise for assisting pathologists and could improve diagnostic accuracy. Rigorously evaluating the ways CAD cues can influence clinicians’ behavior, positively or negatively, is necessary to ensure that CAD improves outcomes as intended without introducing unanticipated but dangerous downsides. Our prior work in radiology showed that CAD tools can capture attention, induce overreliance, and actually lead to worse accuracy when used in practice. We hypothesize CAD may exert similar effects in pathology if employed ineffectively. By studying the impact of CAD cues on a large sample of pathologists, the proposed research will inform best practices for deploying CAD tools into clinical practice and have a profound impact on cancer diagnoses and patient care. Our project will randomize 250 pathologists to the presentation of different types and timing of CAD cues in 3 phases of interpretation. We will examine the impact on pathologists’ interpretive behavior and accuracy of two different types of CAD cues (Feature cues vs. Feature + Diagnosis cues; Aim 1), and two different timings of CAD cue presentation (Immediately upon review of the case vs. Delayed until after completing initial review; Aim 2). Finally, we will leverage eye-tracking to obtain a more granular understanding of the perceptual and cognitive mechanisms underlying the effects of CAD on interpretive behavior and accuracy (Aim 3). Strengths of our application include: 1) our experienced, multidisciplinary team with a history of successful physician recruitment; 2) access to existing and uniquely well-characterized biopsy cases; 3) use of a machine learning algorithm that our team developed in prior NIH funded research to create different CAD cues; 4) established relationships with 12 clinical sites across the country for participant recruitment; 5) an innovative remote image viewing and tracking platform for data collection; and 6) a scientific advisory board comprised of industry partners and clinical experts who will provide their insight and expertise to ensure that our results are immediately actionable for clinical practice. The proposed work is innovative, pioneering, and timely, addressing fundamental questions that accompany the introduction of new AI/CAD tools into the clinic. Our findings will evaluate the impact of CAD and illuminate the cognitive mechanisms that underlie successes and errors that occur during the diagnostic process as physicians interact with CAD cues. The results will inform solutions to guide the successful implementation of CAD into clinical practice to enhance its benefits, mitigate harms, and optimize benefit for patients.



Publications


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