Grant Details
Grant Number: |
3U01CA253858-02S1 Interpret this number |
Primary Investigator: |
Meza, Rafael |
Organization: |
University Of Michigan At Ann Arbor |
Project Title: |
Cisnet Lung Disparities Supplement |
Fiscal Year: |
2021 |
Abstract
Project Summary Abstract
Lung cancer is the third most common cancer in the U.S and the leading cause of cancer
deaths. Although lung cancer incidence and mortality in the US are decreasing, important
differences by gender and race remain. Despite having lower smoking rates than other racial
groups, Black men face the highest incidence and mortality rate of lung cancer in the US.
Similarly, Black women have lower smoking rates than White women in the US, but have
comparable lung cancer incidence and mortality rates to White women and higher lung cancer
rates than other racial/ethnic groups. Lung cancer incidence by histology also differs greatly by
race/ethnicity, with Black men and women being at higher risk for squamous cell carcinoma
than other racial/ethnic groups. Given the observed heterogeneity in screening efficacy by
histological type, these differences could affect the effectiveness of lung cancer screening in the
Black population. The CISNET models of lung cancer natural history have been useful tools to
understand the impacts of preventive interventions (tobacco control and screening) on lung
cancer at a population level. We propose to extend and use one of the CISNET Lung models,
MichiganLung, to 1) model lung cancer incidence and mortality in the US Non-Hispanic Black
population (NHB), 2) determine the contributions of various factors along the cancer control
continuum to disparities in lung cancer mortality in NHB relative to the whole population, and 3)
evaluate the potential impact of screening and other interventions to reduce lung cancer burden
and existing disparities in NHB.
Publications
None. See parent grant details.