||3P01CA229997-03S1 Interpret this number
||University Of Alabama At Birmingham
||Adapting Multiple Behavior Interventions That Effectively Improve (AMPLIFI) Cancer Survivor Health
The supplement will add measures to the AMPLIFI P01 (abbreviated summary below) & enhance its contribution
to the ADOPT Consortium. By 2020, the number of US cancer survivors will exceed 20 million. Cancer
survivorship is a victory, but it comes at a price. Once a person is diagnosed with cancer, they are at much higher
risk for 2nd cancers, cardiovascular disease, diabetes, osteoporosis, and functional decline (downstream effects
estimated at$135 billion/year). A poor diet resulting in obesity and physical inactivity associates with poorer
outcomes after a cancer diagnosis. It is hypothesized that cancer survivors may be able to improve their overall
health and reduce comorbidity through lifestyle change; particularly since only 15-47% of cancer survivors
adhere to national guidelines for weight status, diet and physical activity. While effective intervention sexist, there
has been little effort to disseminate these broad scale and to survivors most in need (older, rural, minorities).
There also is a dearth of research determining optimal means of combining interventions, which is critical since
many survivors practice multiple suboptimal behaviors. The overarching aims AMPLIFI are: 1) improve health
behaviors in cancer survivors who practice multiple suboptimal health behaviors; and 2) adapt efficacious
interventions to optimize reach via technology while also collecting data to inform the future dissemination and
implementation (D&I) potential of these interventions. AMPLIFI involves 3 highly interrelated research projects
supported by 4 integrated cores. It will enlist the efforts of652 survivors of a broad array of cancers that have
favorable 5-year survival rates (oversampling older, rural, minorities) and gather the input of 48 key stakeholders.
Specific Aims: 1) Understand how to adapt efficacious interventions for widespread dissemination via
technology, while maintaining the integrity of key components that drive behavior change; 2) Optimize
acceptability and use of interventions among older, rural, minority survivors of many cancer types; 3) Test the
efficacy of the adapted interventions delivered alone, in sequence, or combined; 4) Contribute to D&I research
by developing a new adaptation model; and 5) Determine factors that improve the D&I potential of distance-
delivered health behavior change interventions by determining how they mediate behavior change and in whom
they work best. Our ultimate goal is to improve the health of the ever-increasing population of cancer survivors.
None. See parent grant details.